Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis

Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation in the bloodstream, is one of the main hallmarks in nanomedicine, especially that of NIR fluorescent probes for cancer theragnosis. The here...

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Autores: Bonelli Blasco, Joaquin Daniel, Velasco de Andrés, María, Isidro, Neus, Bayó, Cristina, Chumillas, Sergi, Carrillo-Serradell, Laura, Casadó Llombart, Sergi, Mok, Cheryl, Benítez-Ribas, Daniel, Lozano Soto, Francisco, Rocas Sorolla, Josep, Marchán Sancho, Vicente
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/197404
Acesso em linha:https://hdl.handle.net/2445/197404
Access Level:acceso abierto
Palavra-chave:Biocompatibilitat
Tumors
Poliuretans
Biocompatibility
Polyurethanes
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spelling Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosisBonelli Blasco, Joaquin DanielVelasco de Andrés, MaríaIsidro, NeusBayó, CristinaChumillas, SergiCarrillo-Serradell, LauraCasadó Llombart, SergiMok, CherylBenítez-Ribas, DanielLozano Soto, FranciscoRocas Sorolla, JosepMarchán Sancho, VicenteBiocompatibilitatTumorsPoliuretansBiocompatibilityTumorsPolyurethanesEncapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation in the bloodstream, is one of the main hallmarks in nanomedicine, especially that of NIR fluorescent probes for cancer theragnosis. The herein reported technology furnishes water-dispersible double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG-NCs), using a versatile and highly efficient one-pot and industrially scalable synthetic process based on the use of two different prepolymers to set up the NCs walls. Flow cytometry and confocal microscopy confirmed that both ICG-loaded NCs internalized in monocyte-derived dendritic cells (moDCs). The in vivo analysis of xenograft A375 mouse melanoma model revealed that amphoteric functionalization of NCs' surface promotes the selective accumulation of ICG-NCs in tumor tissues, making them promising agents for a less-invasive theragnosis of cancer.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/197404Articles publicats en revistes (Química Inorgànica i Orgànica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a:Pharmaceutics, 2022, vol. 15, num. 1, p. 58https://doi.org/10.3390/pharmaceutics15010058cc-by (c) Bonelli Blasco, Joaquin Daniel et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1974042026-05-27T06:46:51Z
dc.title.none.fl_str_mv Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis
title Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis
spellingShingle Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis
Bonelli Blasco, Joaquin Daniel
Biocompatibilitat
Tumors
Poliuretans
Biocompatibility
Tumors
Polyurethanes
title_short Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis
title_full Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis
title_fullStr Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis
title_full_unstemmed Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis
title_sort Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis
dc.creator.none.fl_str_mv Bonelli Blasco, Joaquin Daniel
Velasco de Andrés, María
Isidro, Neus
Bayó, Cristina
Chumillas, Sergi
Carrillo-Serradell, Laura
Casadó Llombart, Sergi
Mok, Cheryl
Benítez-Ribas, Daniel
Lozano Soto, Francisco
Rocas Sorolla, Josep
Marchán Sancho, Vicente
author Bonelli Blasco, Joaquin Daniel
author_facet Bonelli Blasco, Joaquin Daniel
Velasco de Andrés, María
Isidro, Neus
Bayó, Cristina
Chumillas, Sergi
Carrillo-Serradell, Laura
Casadó Llombart, Sergi
Mok, Cheryl
Benítez-Ribas, Daniel
Lozano Soto, Francisco
Rocas Sorolla, Josep
Marchán Sancho, Vicente
author_role author
author2 Velasco de Andrés, María
Isidro, Neus
Bayó, Cristina
Chumillas, Sergi
Carrillo-Serradell, Laura
Casadó Llombart, Sergi
Mok, Cheryl
Benítez-Ribas, Daniel
Lozano Soto, Francisco
Rocas Sorolla, Josep
Marchán Sancho, Vicente
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biocompatibilitat
Tumors
Poliuretans
Biocompatibility
Tumors
Polyurethanes
topic Biocompatibilitat
Tumors
Poliuretans
Biocompatibility
Tumors
Polyurethanes
description Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation in the bloodstream, is one of the main hallmarks in nanomedicine, especially that of NIR fluorescent probes for cancer theragnosis. The herein reported technology furnishes water-dispersible double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG-NCs), using a versatile and highly efficient one-pot and industrially scalable synthetic process based on the use of two different prepolymers to set up the NCs walls. Flow cytometry and confocal microscopy confirmed that both ICG-loaded NCs internalized in monocyte-derived dendritic cells (moDCs). The in vivo analysis of xenograft A375 mouse melanoma model revealed that amphoteric functionalization of NCs' surface promotes the selective accumulation of ICG-NCs in tumor tissues, making them promising agents for a less-invasive theragnosis of cancer.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/197404
url https://hdl.handle.net/2445/197404
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a:
Pharmaceutics, 2022, vol. 15, num. 1, p. 58
https://doi.org/10.3390/pharmaceutics15010058
dc.rights.none.fl_str_mv cc-by (c) Bonelli Blasco, Joaquin Daniel et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Bonelli Blasco, Joaquin Daniel et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Química Inorgànica i Orgànica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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