Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.

Classical Pavlovian fear conditioning remains the most widely employed experimental model of fear and anxiety, and continues to inform contemporary pathophysiological accounts of clinical anxiety disorders. Despite its widespread application in human and animal studies, the neurobiological basis of...

Descripción completa

Detalles Bibliográficos
Autores: Fullana Rivas, Miguel Ángel, Harrison, Ben J., Soriano Mas, Carles, Vervliet, Bram, Cardoner, Narcís, Àvila-Parcet, A., Radua, Joaquim
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/26026
Acceso en línea:http://hdl.handle.net/10230/26026
http://dx.doi.org/10.1038/mp.2015.88
Access Level:acceso abierto
Palabra clave:Ansietat
Por
id ES_0b71abb9d53fb8a3fcb5a2645dbff786
oai_identifier_str oai:repositori.upf.edu:10230/26026
network_acronym_str ES
network_name_str España
repository_id_str
spelling Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.Fullana Rivas, Miguel ÁngelHarrison, Ben J.Soriano Mas, CarlesVervliet, BramCardoner, NarcísÀvila-Parcet, A.Radua, JoaquimAnsietatPorClassical Pavlovian fear conditioning remains the most widely employed experimental model of fear and anxiety, and continues to inform contemporary pathophysiological accounts of clinical anxiety disorders. Despite its widespread application in human and animal studies, the neurobiological basis of fear conditioning remains only partially understood. Here we provide a comprehensive meta-analysis of human fear-conditioning studies carried out with functional magnetic resonance imaging (fMRI), yielding a pooled sample of 677 participants from 27 independent studies. As a distinguishing feature of this meta-analysis, original statistical brain maps were obtained from the authors of 13 of these studies. Our primary analyses demonstrate that human fear conditioning is associated with a consistent and robust pattern of neural activation across a hypothesized genuine network of brain regions resembling existing anatomical descriptions of the 'central autonomic-interoceptive network'. This finding is discussed with a particular emphasis on the neural substrates of conscious fear processing. Our associated meta-analysis of functional deactivations-a scarcely addressed dynamic in fMRI fear-conditioning studies-also suggests the existence of a coordinated brain response potentially underlying the 'safety signal' (that is, non-threat) processing. We attempt to provide an integrated summary on these findings with the view that they may inform ongoing studies of fear-conditioning processes both in healthy and clinical populations, as investigated with neuroimaging and other experimental approaches.This work was supported by ‘Miguel Servet’ contracts from the Carlos III Health Institute (Spain) to CS-M CP10/00604) and JR (CP14/00041), grants from Carlos III Health Institute/FEDER to MAF/NC (PI12/00273) and CS-M (PI13/01958), and an Australian NHMRC Project Grant to BJH (APP1025619).Nature Publishing Group201620162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26026http://dx.doi.org/10.1038/mp.2015.88reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésMolecular Psychiatry. 2016 Apr;21(4):500-8c) Nature Publishing Group http://dx.doi.org/10.1038/mp.2015.88info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/260262026-06-12T07:21:37Z
dc.title.none.fl_str_mv Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.
title Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.
spellingShingle Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.
Fullana Rivas, Miguel Ángel
Ansietat
Por
title_short Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.
title_full Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.
title_fullStr Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.
title_full_unstemmed Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.
title_sort Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies.
dc.creator.none.fl_str_mv Fullana Rivas, Miguel Ángel
Harrison, Ben J.
Soriano Mas, Carles
Vervliet, Bram
Cardoner, Narcís
Àvila-Parcet, A.
Radua, Joaquim
author Fullana Rivas, Miguel Ángel
author_facet Fullana Rivas, Miguel Ángel
Harrison, Ben J.
Soriano Mas, Carles
Vervliet, Bram
Cardoner, Narcís
Àvila-Parcet, A.
Radua, Joaquim
author_role author
author2 Harrison, Ben J.
Soriano Mas, Carles
Vervliet, Bram
Cardoner, Narcís
Àvila-Parcet, A.
Radua, Joaquim
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ansietat
Por
topic Ansietat
Por
description Classical Pavlovian fear conditioning remains the most widely employed experimental model of fear and anxiety, and continues to inform contemporary pathophysiological accounts of clinical anxiety disorders. Despite its widespread application in human and animal studies, the neurobiological basis of fear conditioning remains only partially understood. Here we provide a comprehensive meta-analysis of human fear-conditioning studies carried out with functional magnetic resonance imaging (fMRI), yielding a pooled sample of 677 participants from 27 independent studies. As a distinguishing feature of this meta-analysis, original statistical brain maps were obtained from the authors of 13 of these studies. Our primary analyses demonstrate that human fear conditioning is associated with a consistent and robust pattern of neural activation across a hypothesized genuine network of brain regions resembling existing anatomical descriptions of the 'central autonomic-interoceptive network'. This finding is discussed with a particular emphasis on the neural substrates of conscious fear processing. Our associated meta-analysis of functional deactivations-a scarcely addressed dynamic in fMRI fear-conditioning studies-also suggests the existence of a coordinated brain response potentially underlying the 'safety signal' (that is, non-threat) processing. We attempt to provide an integrated summary on these findings with the view that they may inform ongoing studies of fear-conditioning processes both in healthy and clinical populations, as investigated with neuroimaging and other experimental approaches.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26026
http://dx.doi.org/10.1038/mp.2015.88
url http://hdl.handle.net/10230/26026
http://dx.doi.org/10.1038/mp.2015.88
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular Psychiatry. 2016 Apr;21(4):500-8
dc.rights.none.fl_str_mv c) Nature Publishing Group http://dx.doi.org/10.1038/mp.2015.88
info:eu-repo/semantics/openAccess
rights_invalid_str_mv c) Nature Publishing Group http://dx.doi.org/10.1038/mp.2015.88
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403223623729152
score 15,81155

Similares en LA Referencia