Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment

Hydrothermal (H) processes accelerate the hydrolysis reaction of α-TCP compared tothe long-establishe dbiomimetic (B) treatments. They are of special interest for patient-specific 3D-printed bone graft substitutes, where the manufacturing time represents a critical constraint. Altering the reaction...

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Autores: Raymond, Yago, Bonany, Mar, Lehmann, Cyril, Thorel, Emilie, Benítez, Raúl, Franch, Jordi, Espanol, Montserrat, Solé Martí, Xavi, Manzanares, María Cristina, Canal, Cristina, Ginebra, Maria Pau
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/181738
Acceso en línea:https://hdl.handle.net/2445/181738
Access Level:acceso abierto
Palabra clave:Empelts ossis
Medicina regenerativa
Bone grafting
Regenerative medicine
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spelling Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatmentRaymond, YagoBonany, MarLehmann, CyrilThorel, EmilieBenítez, RaúlFranch, JordiEspanol, MontserratSolé Martí, XaviManzanares, María CristinaCanal, CristinaGinebra, Maria PauEmpelts ossisMedicina regenerativaBone graftingRegenerative medicineHydrothermal (H) processes accelerate the hydrolysis reaction of α-TCP compared tothe long-establishe dbiomimetic (B) treatments. They are of special interest for patient-specific 3D-printed bone graft substitutes, where the manufacturing time represents a critical constraint. Altering the reaction conditions hasimplications forthe physicochemical propertiesof the reaction product. However, the impact of the changes produced by the hydrothermal reaction on the invivo performancewas hitherto unknown.The present study compares the bone regeneration potential of 3D printed α-TCP scaffolds hardened using these two treatments in rabbit condyle monocortical defects. Although both consolidation processes resulted in biocompatible scaffolds with osseointegrative and osteoconductive properties, the amount of newly formed bone increased by one third in the hydrothermal vs the biomimetic samples. B and H scaffolds consisted mostly of high specific surface area calcium deficient hydroxyapatite (38 and 27 m2/g respectively), with H samples containing also 10 wt. %β-TCP. The shrinkage produced during the consolidation process was shown to be very small in both cases, below 3%, and smaller for H than for B samples. The differences in the in vivo performance were mainly attributed to the distinct crystallisation nanostructures, which proved to have a major impact on permeability and protein adsorption capacity, using BSA as a model protein, with B samples being highly impermeable. Given the crucial role that soluble proteins play in osteogenesis, this is proposed to be a relevant factor behind the distinct in vivo performances observed for the two materials.Elsevier B.V.202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion18 p.application/pdfhttps://hdl.handle.net/2445/181738Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.actbio.2021.09.001Acta Biomaterialia, 2021, vol. 135, p. 671-688https://doi.org/10.1016/j.actbio.2021.09.001cc-by-nc-nd (c) Elsevier B.V., 2021https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1817382026-05-29T05:05:01Z
dc.title.none.fl_str_mv Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
title Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
spellingShingle Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
Raymond, Yago
Empelts ossis
Medicina regenerativa
Bone grafting
Regenerative medicine
title_short Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
title_full Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
title_fullStr Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
title_full_unstemmed Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
title_sort Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment
dc.creator.none.fl_str_mv Raymond, Yago
Bonany, Mar
Lehmann, Cyril
Thorel, Emilie
Benítez, Raúl
Franch, Jordi
Espanol, Montserrat
Solé Martí, Xavi
Manzanares, María Cristina
Canal, Cristina
Ginebra, Maria Pau
author Raymond, Yago
author_facet Raymond, Yago
Bonany, Mar
Lehmann, Cyril
Thorel, Emilie
Benítez, Raúl
Franch, Jordi
Espanol, Montserrat
Solé Martí, Xavi
Manzanares, María Cristina
Canal, Cristina
Ginebra, Maria Pau
author_role author
author2 Bonany, Mar
Lehmann, Cyril
Thorel, Emilie
Benítez, Raúl
Franch, Jordi
Espanol, Montserrat
Solé Martí, Xavi
Manzanares, María Cristina
Canal, Cristina
Ginebra, Maria Pau
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Empelts ossis
Medicina regenerativa
Bone grafting
Regenerative medicine
topic Empelts ossis
Medicina regenerativa
Bone grafting
Regenerative medicine
description Hydrothermal (H) processes accelerate the hydrolysis reaction of α-TCP compared tothe long-establishe dbiomimetic (B) treatments. They are of special interest for patient-specific 3D-printed bone graft substitutes, where the manufacturing time represents a critical constraint. Altering the reaction conditions hasimplications forthe physicochemical propertiesof the reaction product. However, the impact of the changes produced by the hydrothermal reaction on the invivo performancewas hitherto unknown.The present study compares the bone regeneration potential of 3D printed α-TCP scaffolds hardened using these two treatments in rabbit condyle monocortical defects. Although both consolidation processes resulted in biocompatible scaffolds with osseointegrative and osteoconductive properties, the amount of newly formed bone increased by one third in the hydrothermal vs the biomimetic samples. B and H scaffolds consisted mostly of high specific surface area calcium deficient hydroxyapatite (38 and 27 m2/g respectively), with H samples containing also 10 wt. %β-TCP. The shrinkage produced during the consolidation process was shown to be very small in both cases, below 3%, and smaller for H than for B samples. The differences in the in vivo performance were mainly attributed to the distinct crystallisation nanostructures, which proved to have a major impact on permeability and protein adsorption capacity, using BSA as a model protein, with B samples being highly impermeable. Given the crucial role that soluble proteins play in osteogenesis, this is proposed to be a relevant factor behind the distinct in vivo performances observed for the two materials.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181738
url https://hdl.handle.net/2445/181738
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.actbio.2021.09.001
Acta Biomaterialia, 2021, vol. 135, p. 671-688
https://doi.org/10.1016/j.actbio.2021.09.001
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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