MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients

Background: In recent years, microRNA (miRNA) pathways have emerged as a crucial system for the regulation of tumorogenesis. miR-SNPs are a novel class of single nucleotide polymorphisms that can affect miRNA pathways. Design and Methods: We analyzed eight miR-SNPs by allelic discrimination in 141 p...

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Autores: Navarro Ponz, Alfons, Muñoz, Carmen, Gaya, Anna, Díaz Beyà, Marina, Gel Moreno, Bernat, Tejero Villalba, Rut, Díaz Sánchez, Tania, Martínez Pozo, Antonio, Monzó Planella, Mariano
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/52827
Acceso en línea:https://hdl.handle.net/2445/52827
Access Level:acceso abierto
Palabra clave:Malaltia de Hodgkin
Micro RNAs
Limfomes
Hodgkin's disease
MicroRNAs
Lymphomas
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spelling MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patientsNavarro Ponz, AlfonsMuñoz, CarmenGaya, AnnaDíaz Beyà, MarinaGel Moreno, BernatTejero Villalba, RutDíaz Sánchez, TaniaMartínez Pozo, AntonioMonzó Planella, MarianoMalaltia de HodgkinMicro RNAsLimfomesHodgkin's diseaseMicroRNAsLymphomasBackground: In recent years, microRNA (miRNA) pathways have emerged as a crucial system for the regulation of tumorogenesis. miR-SNPs are a novel class of single nucleotide polymorphisms that can affect miRNA pathways. Design and Methods: We analyzed eight miR-SNPs by allelic discrimination in 141 patients with Hodgkin lymphoma and correlated the results with treatment-related toxicity, response, disease-free survival (DFS) and overall survival (OS). Results: The KRT81 (rs3660) GG genotype was associated with an increased risk of neurological toxicity (P=0.016), while patients with XPO5 (rs11077) AA or CC genotypes had a higher rate of bleomycin-associated pulmonary toxicity (P=0.048). Both miR-SNPs emerged as independent factors in the multivariate analysis. The XPO5 AA and CC genotypes were also associated with a lower response rate (P=0.036). XPO5 (P=0.039) and TRBP (rs784567) (P=0.022) genotypes emerged as prognostic markers for DFS, and XPO5 was also associated with OS (P=0.033). In the multivariate analysis, only XPO5 emerged as an independent prognostic factor for DFS (HR: 2.622; 95%CI 1.039-6.620; P=0.041). Given the influence of XPO5 and TRBP as individual markers, we then investigated the combined effect of these miR-SNPs. Patients with both the XPO5 AA/CC and TRBP TT/TC genotypes had the shortest DFS (P=0.008) and OS (P=0.008). Conclusion: miR-SNPs can add useful prognostic information on treatment-related toxicity and clinical outcome in Hodgkin lymphoma and can be used to identify patients likely to be chemoresistant or to relapse.Public Library of Science (PLoS)2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/52827Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0064716PLoS One, 2013, vol. 8, num. 5, p. e64716http://dx.doi.org/10.1371/journal.pone.0064716cc-by (c) Navarro Ponz, Alfons et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/528272026-05-27T06:46:51Z
dc.title.none.fl_str_mv MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients
title MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients
spellingShingle MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients
Navarro Ponz, Alfons
Malaltia de Hodgkin
Micro RNAs
Limfomes
Hodgkin's disease
MicroRNAs
Lymphomas
title_short MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients
title_full MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients
title_fullStr MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients
title_full_unstemmed MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients
title_sort MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients
dc.creator.none.fl_str_mv Navarro Ponz, Alfons
Muñoz, Carmen
Gaya, Anna
Díaz Beyà, Marina
Gel Moreno, Bernat
Tejero Villalba, Rut
Díaz Sánchez, Tania
Martínez Pozo, Antonio
Monzó Planella, Mariano
author Navarro Ponz, Alfons
author_facet Navarro Ponz, Alfons
Muñoz, Carmen
Gaya, Anna
Díaz Beyà, Marina
Gel Moreno, Bernat
Tejero Villalba, Rut
Díaz Sánchez, Tania
Martínez Pozo, Antonio
Monzó Planella, Mariano
author_role author
author2 Muñoz, Carmen
Gaya, Anna
Díaz Beyà, Marina
Gel Moreno, Bernat
Tejero Villalba, Rut
Díaz Sánchez, Tania
Martínez Pozo, Antonio
Monzó Planella, Mariano
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Hodgkin
Micro RNAs
Limfomes
Hodgkin's disease
MicroRNAs
Lymphomas
topic Malaltia de Hodgkin
Micro RNAs
Limfomes
Hodgkin's disease
MicroRNAs
Lymphomas
description Background: In recent years, microRNA (miRNA) pathways have emerged as a crucial system for the regulation of tumorogenesis. miR-SNPs are a novel class of single nucleotide polymorphisms that can affect miRNA pathways. Design and Methods: We analyzed eight miR-SNPs by allelic discrimination in 141 patients with Hodgkin lymphoma and correlated the results with treatment-related toxicity, response, disease-free survival (DFS) and overall survival (OS). Results: The KRT81 (rs3660) GG genotype was associated with an increased risk of neurological toxicity (P=0.016), while patients with XPO5 (rs11077) AA or CC genotypes had a higher rate of bleomycin-associated pulmonary toxicity (P=0.048). Both miR-SNPs emerged as independent factors in the multivariate analysis. The XPO5 AA and CC genotypes were also associated with a lower response rate (P=0.036). XPO5 (P=0.039) and TRBP (rs784567) (P=0.022) genotypes emerged as prognostic markers for DFS, and XPO5 was also associated with OS (P=0.033). In the multivariate analysis, only XPO5 emerged as an independent prognostic factor for DFS (HR: 2.622; 95%CI 1.039-6.620; P=0.041). Given the influence of XPO5 and TRBP as individual markers, we then investigated the combined effect of these miR-SNPs. Patients with both the XPO5 AA/CC and TRBP TT/TC genotypes had the shortest DFS (P=0.008) and OS (P=0.008). Conclusion: miR-SNPs can add useful prognostic information on treatment-related toxicity and clinical outcome in Hodgkin lymphoma and can be used to identify patients likely to be chemoresistant or to relapse.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/52827
url https://hdl.handle.net/2445/52827
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0064716
PLoS One, 2013, vol. 8, num. 5, p. e64716
http://dx.doi.org/10.1371/journal.pone.0064716
dc.rights.none.fl_str_mv cc-by (c) Navarro Ponz, Alfons et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Navarro Ponz, Alfons et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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