Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index
To evaluate health-related quality of life in a large series of primary SS patients using the recently-proposed ESSPRI questionnaire and to evaluate the relationship between the intensity of oral dryness and other signs and symptoms frequently found in these patients. METHODS: We evaluated 90 primar...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2014 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositório: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/122429 |
| Acesso em linha: | https://hdl.handle.net/2445/122429 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Síndrome de Sjögren Malalties autoimmunitàries Ansietat Diabetis Dolor Depressió psíquica Estudi de casos Sjogren's syndrome Autoimmune diseases Anxiety Diabetes Pain Mental depression Case studies |
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Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI indexGandía, MyriamMorales-Espinoza, Enma MarianelaM.Martín-González, Rosa Ma.Retamozo, María SoledadKostov, BelchinBelenguer-Prieto, RafaelBuss, DavidCaballero Borrego, MiguelBové Boada, AlbertGueitasi, HodaBrito Zerón, María del PilarSisó Almirall, AntoniSoto-Cárdenas, Maria JoséRamos Casals, ManuelSíndrome de SjögrenMalalties autoimmunitàriesAnsietatDiabetisDolorDepressió psíquicaEstudi de casosSjogren's syndromeAutoimmune diseasesAnxietyDiabetesPainMental depressionCase studiesTo evaluate health-related quality of life in a large series of primary SS patients using the recently-proposed ESSPRI questionnaire and to evaluate the relationship between the intensity of oral dryness and other signs and symptoms frequently found in these patients. METHODS: We evaluated 90 primary SS patients seen consecutively; all fulfilled the current classification criteria. All patients completed the ESSPRI questionnaire. We compared the mean values of the ESSPRI-dry mouth item with other ESSPRI items related to sicca features, general symptoms, quality of life, quality of sleep, psychological and psychiatric features, extraglandular involvement, laboratory features and immunological markers and cardiovascular risk factors. Multivariate regression analysis with a backwards stepwise selection method was performed to identify those variables that were independently associated with dry mouth. RESULTS: Mean intensity of oral dryness measured by the corresponding ESSPRI item was 7.17±0.23. Oral dryness correlated with age both at diagnosis and at study inclusion (p=0.013), but not with gender or with time of disease evolution. No significant correlation was found with the SF-36, HAQ and FIQ questionnaires. We found a significant correlation between the intensity of oral dryness and the quality of sleep (p=0.001), anxiety and depression measured by the GH28 (p=0.004 and 0.024, respectively), and a statistically-significant trend for anxiety and depression measured by the HADS (p=0.08 and 0.07, respectively). No significant correlation was found with the main extraglandular and immunological features; however, a significant correlation between oral dryness and hypertension (p=0.019), type II diabetes mellitus (p=0.005) and hypercholesterolemia (p=0.011) was found. Multivariate regression analysis shows that fatigue measured by ESSPRI (p=0.049), sleep quality (p=0.008) and hypercholesterolemia (p=0.008) were independently associated with dry mouth. CONCLUSION: We report on the usefulness of the ESSPRI index in evaluating HRQOL associated with oral dryness in primary SS patients. Oral dryness correlated with age and the other sicca symptoms measured by ESSPRI, but not with the main systemic and immunological SS features. In contrast, oral dryness was strongly correlated with fatigue, pain, psychological distress, poor sleep and vascular risk factors. A multidisciplinary therapeutic approach may be the best way of minimizing oral dryness and its consequences in primary SS patientsOMICS Publishing Group2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/122429Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://www.ncbi.nlm.nih.gov/pubmed/24984655Oral Health and Dental Management, 2014, vol. 13, num. 2, p. 402-407cc-by (c) Gandía, Myriam et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1224292026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index |
| title |
Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index |
| spellingShingle |
Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index Gandía, Myriam Síndrome de Sjögren Malalties autoimmunitàries Ansietat Diabetis Dolor Depressió psíquica Estudi de casos Sjogren's syndrome Autoimmune diseases Anxiety Diabetes Pain Mental depression Case studies |
| title_short |
Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index |
| title_full |
Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index |
| title_fullStr |
Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index |
| title_full_unstemmed |
Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index |
| title_sort |
Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index |
| dc.creator.none.fl_str_mv |
Gandía, Myriam Morales-Espinoza, Enma MarianelaM. Martín-González, Rosa Ma. Retamozo, María Soledad Kostov, Belchin Belenguer-Prieto, Rafael Buss, David Caballero Borrego, Miguel Bové Boada, Albert Gueitasi, Hoda Brito Zerón, María del Pilar Sisó Almirall, Antoni Soto-Cárdenas, Maria José Ramos Casals, Manuel |
| author |
Gandía, Myriam |
| author_facet |
Gandía, Myriam Morales-Espinoza, Enma MarianelaM. Martín-González, Rosa Ma. Retamozo, María Soledad Kostov, Belchin Belenguer-Prieto, Rafael Buss, David Caballero Borrego, Miguel Bové Boada, Albert Gueitasi, Hoda Brito Zerón, María del Pilar Sisó Almirall, Antoni Soto-Cárdenas, Maria José Ramos Casals, Manuel |
| author_role |
author |
| author2 |
Morales-Espinoza, Enma MarianelaM. Martín-González, Rosa Ma. Retamozo, María Soledad Kostov, Belchin Belenguer-Prieto, Rafael Buss, David Caballero Borrego, Miguel Bové Boada, Albert Gueitasi, Hoda Brito Zerón, María del Pilar Sisó Almirall, Antoni Soto-Cárdenas, Maria José Ramos Casals, Manuel |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Síndrome de Sjögren Malalties autoimmunitàries Ansietat Diabetis Dolor Depressió psíquica Estudi de casos Sjogren's syndrome Autoimmune diseases Anxiety Diabetes Pain Mental depression Case studies |
| topic |
Síndrome de Sjögren Malalties autoimmunitàries Ansietat Diabetis Dolor Depressió psíquica Estudi de casos Sjogren's syndrome Autoimmune diseases Anxiety Diabetes Pain Mental depression Case studies |
| description |
To evaluate health-related quality of life in a large series of primary SS patients using the recently-proposed ESSPRI questionnaire and to evaluate the relationship between the intensity of oral dryness and other signs and symptoms frequently found in these patients. METHODS: We evaluated 90 primary SS patients seen consecutively; all fulfilled the current classification criteria. All patients completed the ESSPRI questionnaire. We compared the mean values of the ESSPRI-dry mouth item with other ESSPRI items related to sicca features, general symptoms, quality of life, quality of sleep, psychological and psychiatric features, extraglandular involvement, laboratory features and immunological markers and cardiovascular risk factors. Multivariate regression analysis with a backwards stepwise selection method was performed to identify those variables that were independently associated with dry mouth. RESULTS: Mean intensity of oral dryness measured by the corresponding ESSPRI item was 7.17±0.23. Oral dryness correlated with age both at diagnosis and at study inclusion (p=0.013), but not with gender or with time of disease evolution. No significant correlation was found with the SF-36, HAQ and FIQ questionnaires. We found a significant correlation between the intensity of oral dryness and the quality of sleep (p=0.001), anxiety and depression measured by the GH28 (p=0.004 and 0.024, respectively), and a statistically-significant trend for anxiety and depression measured by the HADS (p=0.08 and 0.07, respectively). No significant correlation was found with the main extraglandular and immunological features; however, a significant correlation between oral dryness and hypertension (p=0.019), type II diabetes mellitus (p=0.005) and hypercholesterolemia (p=0.011) was found. Multivariate regression analysis shows that fatigue measured by ESSPRI (p=0.049), sleep quality (p=0.008) and hypercholesterolemia (p=0.008) were independently associated with dry mouth. CONCLUSION: We report on the usefulness of the ESSPRI index in evaluating HRQOL associated with oral dryness in primary SS patients. Oral dryness correlated with age and the other sicca symptoms measured by ESSPRI, but not with the main systemic and immunological SS features. In contrast, oral dryness was strongly correlated with fatigue, pain, psychological distress, poor sleep and vascular risk factors. A multidisciplinary therapeutic approach may be the best way of minimizing oral dryness and its consequences in primary SS patients |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/122429 |
| url |
https://hdl.handle.net/2445/122429 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://www.ncbi.nlm.nih.gov/pubmed/24984655 Oral Health and Dental Management, 2014, vol. 13, num. 2, p. 402-407 |
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cc-by (c) Gandía, Myriam et al., 2014 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
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cc-by (c) Gandía, Myriam et al., 2014 http://creativecommons.org/licenses/by/3.0/es |
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openAccess |
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application/pdf |
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OMICS Publishing Group |
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OMICS Publishing Group |
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Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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