Synthesis and impact of neuroestradiol on hippocampal neuronal networks

The production of estradiol within the brain, that is, neuroestradiol (nE2), is widely documented. nE2 deeply impacts adult brain physiology and synaptic plasticity. In the hippocampus, a region of the brain essential for cognitive function, multiple cellular sources, and targets of nE2 have been id...

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Detalhes bibliográficos
Autores: Azcoitia, I., Hernández-Vivanco, Alicia, Cano-Adamuz, Nuria, Méndez, Pablo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/279101
Acesso em linha:http://hdl.handle.net/10261/279101
Access Level:acceso abierto
Palavra-chave:Aromatase, Excitatory neurons, Estradiol, Estrogen, Hippocampus, Inhibitory neurons, Neurosteroids.
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spelling Synthesis and impact of neuroestradiol on hippocampal neuronal networksAzcoitia, I.Hernández-Vivanco, AliciaCano-Adamuz, NuriaMéndez, PabloAromatase, Excitatory neurons, Estradiol, Estrogen, Hippocampus, Inhibitory neurons, Neurosteroids.The production of estradiol within the brain, that is, neuroestradiol (nE2), is widely documented. nE2 deeply impacts adult brain physiology and synaptic plasticity. In the hippocampus, a region of the brain essential for cognitive function, multiple cellular sources, and targets of nE2 have been identified. The impact of estradiol in excitatory and inhibitory neurotransmission suggests a role for regulated nE2 synthesis in the coordination of the activity of different cellular elements of hippocampal network. Here, we review the role of nE2 in the physiology of the hippocampal circuits taking into account the cellular heterogeneity of the hippocampus. We aspire at expanding the consideration of neuron-derived estradiol as a neuromodulator of hippocampal network activities underlying cognition.This work was supported by grants PID2020-112824GB-100 (to PM) funded by MCIN/AEI/ 10.13039/501100011033. N C-A is supported by the PhD fellowship PRE2018-084857 funded by MCIN/AEI/ 10.13039/501100011033 by “ESF Investing in your future” and Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (to IA).ElsevierMinisterio de Ciencia e Innovación (España)Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/279101reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112824GB-I00http://dx.doi.org/10.1016/j.coemr.2022.100335Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2791012026-05-22T06:33:51Z
dc.title.none.fl_str_mv Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title Synthesis and impact of neuroestradiol on hippocampal neuronal networks
spellingShingle Synthesis and impact of neuroestradiol on hippocampal neuronal networks
Azcoitia, I.
Aromatase, Excitatory neurons, Estradiol, Estrogen, Hippocampus, Inhibitory neurons, Neurosteroids.
title_short Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title_full Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title_fullStr Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title_full_unstemmed Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title_sort Synthesis and impact of neuroestradiol on hippocampal neuronal networks
dc.creator.none.fl_str_mv Azcoitia, I.
Hernández-Vivanco, Alicia
Cano-Adamuz, Nuria
Méndez, Pablo
author Azcoitia, I.
author_facet Azcoitia, I.
Hernández-Vivanco, Alicia
Cano-Adamuz, Nuria
Méndez, Pablo
author_role author
author2 Hernández-Vivanco, Alicia
Cano-Adamuz, Nuria
Méndez, Pablo
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aromatase, Excitatory neurons, Estradiol, Estrogen, Hippocampus, Inhibitory neurons, Neurosteroids.
topic Aromatase, Excitatory neurons, Estradiol, Estrogen, Hippocampus, Inhibitory neurons, Neurosteroids.
description The production of estradiol within the brain, that is, neuroestradiol (nE2), is widely documented. nE2 deeply impacts adult brain physiology and synaptic plasticity. In the hippocampus, a region of the brain essential for cognitive function, multiple cellular sources, and targets of nE2 have been identified. The impact of estradiol in excitatory and inhibitory neurotransmission suggests a role for regulated nE2 synthesis in the coordination of the activity of different cellular elements of hippocampal network. Here, we review the role of nE2 in the physiology of the hippocampal circuits taking into account the cellular heterogeneity of the hippocampus. We aspire at expanding the consideration of neuron-derived estradiol as a neuromodulator of hippocampal network activities underlying cognition.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/279101
url http://hdl.handle.net/10261/279101
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112824GB-I00
http://dx.doi.org/10.1016/j.coemr.2022.100335
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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