Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF

Recent results indicate that STriatal-Enriched protein tyrosine Phosphatase (STEP) levels are regulated by brain-derived neurotrophic factor (BDNF), whose expression changes during postnatal development and aging. Here, we studied STEP ontogeny in mouse brain and changes in STEP with age with emphas...

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Authors: Cases, Silvia, Saavedra, Ana, Tyebji, Shiraz, Giralt Torroella, Albert, Alberch i Vié, Jordi, 1959-, Pérez Navarro, Esther
Format: article
Status:Versión aceptada para publicación
Publication Date:2018
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/184462
Online Access:https://hdl.handle.net/2445/184462
Access Level:Open access
Keyword:Envelliment cerebral
Proteïna-tirosina-fosfatasa
Regulació genètica
Diferències entre sexes
Aging brain
Protein-tyrosine phosphatase
Genetic regulation
Sex differences
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spelling Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNFCases, SilviaSaavedra, AnaTyebji, ShirazGiralt Torroella, AlbertAlberch i Vié, Jordi, 1959-Pérez Navarro, EstherEnvelliment cerebralProteïna-tirosina-fosfatasaRegulació genèticaDiferències entre sexesAging brainProtein-tyrosine phosphataseGenetic regulationSex differencesRecent results indicate that STriatal-Enriched protein tyrosine Phosphatase (STEP) levels are regulated by brain-derived neurotrophic factor (BDNF), whose expression changes during postnatal development and aging. Here, we studied STEP ontogeny in mouse brain and changes in STEP with age with emphasis on the possible regulation by BDNF. We found that STEP expression increased during the first weeks of life, reaching adult levels by 2-3 weeks of age in the striatum and cortex, and by postnatal day (P) 7 in the hippocampus. STEP protein levels were unaffected in BDNF+/- mice, but were significantly reduced in the striatum and cortex, but not in the hippocampus, of BDNF-/- mice at P7 and P14. In adult wild-type mice there were no changes in cortical and hippocampal STEP61 levels with age. Conversely, striatal STEP levels were reduced from 12 months of age, correlating with higher ubiquitination and increased BDNF content and signaling. Lower STEP levels in older mice were paralleled by increased phosphorylation of its substrates. Since altered STEP levels are involved in cellular malfunctioning events, its reduction in the striatum with increasing age should encourage future studies of how this imbalance might participate in the aging process.Elsevier B.V.2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/184462Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.mcn.2017.11.003Molecular and Cellular Neuroscience, 2018, vol. 86, p. 41-49https://doi.org/10.1016/j.mcn.2017.11.003cc-by-nc-nd (c) Elsevier B.V., 2018https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1844622026-05-27T06:46:51Z
dc.title.none.fl_str_mv Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF
title Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF
spellingShingle Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF
Cases, Silvia
Envelliment cerebral
Proteïna-tirosina-fosfatasa
Regulació genètica
Diferències entre sexes
Aging brain
Protein-tyrosine phosphatase
Genetic regulation
Sex differences
title_short Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF
title_full Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF
title_fullStr Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF
title_full_unstemmed Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF
title_sort Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF
dc.creator.none.fl_str_mv Cases, Silvia
Saavedra, Ana
Tyebji, Shiraz
Giralt Torroella, Albert
Alberch i Vié, Jordi, 1959-
Pérez Navarro, Esther
author Cases, Silvia
author_facet Cases, Silvia
Saavedra, Ana
Tyebji, Shiraz
Giralt Torroella, Albert
Alberch i Vié, Jordi, 1959-
Pérez Navarro, Esther
author_role author
author2 Saavedra, Ana
Tyebji, Shiraz
Giralt Torroella, Albert
Alberch i Vié, Jordi, 1959-
Pérez Navarro, Esther
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Envelliment cerebral
Proteïna-tirosina-fosfatasa
Regulació genètica
Diferències entre sexes
Aging brain
Protein-tyrosine phosphatase
Genetic regulation
Sex differences
topic Envelliment cerebral
Proteïna-tirosina-fosfatasa
Regulació genètica
Diferències entre sexes
Aging brain
Protein-tyrosine phosphatase
Genetic regulation
Sex differences
description Recent results indicate that STriatal-Enriched protein tyrosine Phosphatase (STEP) levels are regulated by brain-derived neurotrophic factor (BDNF), whose expression changes during postnatal development and aging. Here, we studied STEP ontogeny in mouse brain and changes in STEP with age with emphasis on the possible regulation by BDNF. We found that STEP expression increased during the first weeks of life, reaching adult levels by 2-3 weeks of age in the striatum and cortex, and by postnatal day (P) 7 in the hippocampus. STEP protein levels were unaffected in BDNF+/- mice, but were significantly reduced in the striatum and cortex, but not in the hippocampus, of BDNF-/- mice at P7 and P14. In adult wild-type mice there were no changes in cortical and hippocampal STEP61 levels with age. Conversely, striatal STEP levels were reduced from 12 months of age, correlating with higher ubiquitination and increased BDNF content and signaling. Lower STEP levels in older mice were paralleled by increased phosphorylation of its substrates. Since altered STEP levels are involved in cellular malfunctioning events, its reduction in the striatum with increasing age should encourage future studies of how this imbalance might participate in the aging process.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/184462
url https://hdl.handle.net/2445/184462
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.mcn.2017.11.003
Molecular and Cellular Neuroscience, 2018, vol. 86, p. 41-49
https://doi.org/10.1016/j.mcn.2017.11.003
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2018
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2018
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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