Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression

Background : Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives : We aimed to assess the potential modulating effects of MD...

ver descrição completa

Detalhes bibliográficos
Autores: Salvat-Pujol, Neus|||0000-0001-5320-331X, Labad, Javier|||0000-0003-2214-1886, Urretavizcaya, Mikel|||0000-0002-9746-4068, De Arriba-Arnau, Aida|||0000-0002-7877-7341, Segalàs, Cinto|||0000-0002-0959-0356, Real, Eva|||0000-0003-4523-1649, Ferrer, Alex|||0000-0002-3040-1177, Crespo, José M., Jiménez Murcia, Susana|||0000-0002-3596-8033, Soriano-Mas, Carles|||0000-0003-4574-6597, Menchón Magriñá, José Manuel|||0000-0002-6231-6524, Soria, Virginia|||0000-0001-6412-6831
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255399
Acesso em linha:https://ddd.uab.cat/record/255399
https://dx.doi.org/urn:doi:10.1080/20008198.2020.1857955
Access Level:acceso abierto
Palavra-chave:Childhood abuse
Childhood neglect
Cortisol
HPA axis
Dexamethasone suppression test
Cognition
Memory
Major depression
Abuso infantil
Negligencia infantil
Eje HHA
Prueba de supresión de dexametasona
Cognición
Memoria
Depresión mayor
童年期虐待
儿童忽视
皮质醇
HPA轴
地塞米松抑制试验
认知
记忆
重性抑郁
id ES_0aef50cd9be064aa6788615e57f8d2f6
oai_identifier_str oai:ddd.uab.cat:255399
network_acronym_str ES
network_name_str España
repository_id_str
spelling Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depressioneffects on cognitive performanceSalvat-Pujol, Neus|||0000-0001-5320-331XLabad, Javier|||0000-0003-2214-1886Urretavizcaya, Mikel|||0000-0002-9746-4068De Arriba-Arnau, Aida|||0000-0002-7877-7341Segalàs, Cinto|||0000-0002-0959-0356Real, Eva|||0000-0003-4523-1649Ferrer, Alex|||0000-0002-3040-1177Crespo, José M.Jiménez Murcia, Susana|||0000-0002-3596-8033Soriano-Mas, Carles|||0000-0003-4574-6597Menchón Magriñá, José Manuel|||0000-0002-6231-6524Soria, Virginia|||0000-0001-6412-6831Childhood abuseChildhood neglectCortisolHPA axisDexamethasone suppression testCognitionMemoryMajor depressionAbuso infantilNegligencia infantilEje HHAPrueba de supresión de dexametasonaCogniciónMemoriaDepresión mayor童年期虐待儿童忽视皮质醇HPA轴地塞米松抑制试验认知记忆重性抑郁Background : Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives : We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods : Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results : Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions : HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects. HIGHLIGHTS • We studied the effects of childhood maltreatment (CM), HPA axis feedback (DST), and depression on cognition. • Different types of CM had a distinct impact on cognitive performance. • MDD diagnosis and DST modulated the association between CM and cognition.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255399https://dx.doi.org/urn:doi:10.1080/20008198.2020.1857955reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía, Industria y Competitividad https://doi.org/10.13039/501100010198 PI10/01753Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00662Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI16/00950Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1247Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CP10/00604SLT006/17/00012open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2553992026-06-06T12:50:31Z
dc.title.none.fl_str_mv Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression
effects on cognitive performance
title Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression
spellingShingle Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression
Salvat-Pujol, Neus|||0000-0001-5320-331X
Childhood abuse
Childhood neglect
Cortisol
HPA axis
Dexamethasone suppression test
Cognition
Memory
Major depression
Abuso infantil
Negligencia infantil
Eje HHA
Prueba de supresión de dexametasona
Cognición
Memoria
Depresión mayor
童年期虐待
儿童忽视
皮质醇
HPA轴
地塞米松抑制试验
认知
记忆
重性抑郁
title_short Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression
title_full Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression
title_fullStr Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression
title_full_unstemmed Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression
title_sort Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression
dc.creator.none.fl_str_mv Salvat-Pujol, Neus|||0000-0001-5320-331X
Labad, Javier|||0000-0003-2214-1886
Urretavizcaya, Mikel|||0000-0002-9746-4068
De Arriba-Arnau, Aida|||0000-0002-7877-7341
Segalàs, Cinto|||0000-0002-0959-0356
Real, Eva|||0000-0003-4523-1649
Ferrer, Alex|||0000-0002-3040-1177
Crespo, José M.
Jiménez Murcia, Susana|||0000-0002-3596-8033
Soriano-Mas, Carles|||0000-0003-4574-6597
Menchón Magriñá, José Manuel|||0000-0002-6231-6524
Soria, Virginia|||0000-0001-6412-6831
author Salvat-Pujol, Neus|||0000-0001-5320-331X
author_facet Salvat-Pujol, Neus|||0000-0001-5320-331X
Labad, Javier|||0000-0003-2214-1886
Urretavizcaya, Mikel|||0000-0002-9746-4068
De Arriba-Arnau, Aida|||0000-0002-7877-7341
Segalàs, Cinto|||0000-0002-0959-0356
Real, Eva|||0000-0003-4523-1649
Ferrer, Alex|||0000-0002-3040-1177
Crespo, José M.
Jiménez Murcia, Susana|||0000-0002-3596-8033
Soriano-Mas, Carles|||0000-0003-4574-6597
Menchón Magriñá, José Manuel|||0000-0002-6231-6524
Soria, Virginia|||0000-0001-6412-6831
author_role author
author2 Labad, Javier|||0000-0003-2214-1886
Urretavizcaya, Mikel|||0000-0002-9746-4068
De Arriba-Arnau, Aida|||0000-0002-7877-7341
Segalàs, Cinto|||0000-0002-0959-0356
Real, Eva|||0000-0003-4523-1649
Ferrer, Alex|||0000-0002-3040-1177
Crespo, José M.
Jiménez Murcia, Susana|||0000-0002-3596-8033
Soriano-Mas, Carles|||0000-0003-4574-6597
Menchón Magriñá, José Manuel|||0000-0002-6231-6524
Soria, Virginia|||0000-0001-6412-6831
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Childhood abuse
Childhood neglect
Cortisol
HPA axis
Dexamethasone suppression test
Cognition
Memory
Major depression
Abuso infantil
Negligencia infantil
Eje HHA
Prueba de supresión de dexametasona
Cognición
Memoria
Depresión mayor
童年期虐待
儿童忽视
皮质醇
HPA轴
地塞米松抑制试验
认知
记忆
重性抑郁
topic Childhood abuse
Childhood neglect
Cortisol
HPA axis
Dexamethasone suppression test
Cognition
Memory
Major depression
Abuso infantil
Negligencia infantil
Eje HHA
Prueba de supresión de dexametasona
Cognición
Memoria
Depresión mayor
童年期虐待
儿童忽视
皮质醇
HPA轴
地塞米松抑制试验
认知
记忆
重性抑郁
description Background : Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives : We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods : Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results : Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions : HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects. HIGHLIGHTS • We studied the effects of childhood maltreatment (CM), HPA axis feedback (DST), and depression on cognition. • Different types of CM had a distinct impact on cognitive performance. • MDD diagnosis and DST modulated the association between CM and cognition.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/255399
https://dx.doi.org/urn:doi:10.1080/20008198.2020.1857955
url https://ddd.uab.cat/record/255399
https://dx.doi.org/urn:doi:10.1080/20008198.2020.1857955
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía, Industria y Competitividad https://doi.org/10.13039/501100010198 PI10/01753
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00662
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI16/00950
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1247
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CP10/00604SLT006/17/00012
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403192210489344
score 15,301603

Registos relacionados