Well posedness and numerical solution of kinetic models for angiogenesis

Angiogenesis processes including the effect of stochastic branching and spread of blood vessels can be described coupling a (nonlocal in time) integrodifferential kinetic equation of Fokker-Planck type with a diffusion equation for the angiogenic factor. Well posedness studies underline the importan...

Descripción completa

Detalles Bibliográficos
Autores: Carpio Rodríguez, Ana María, Cebrián, Elena, Duro, Gema
Tipo de recurso: capítulo de libro
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8839
Acceso en línea:https://hdl.handle.net/20.500.14352/8839
Access Level:acceso abierto
Palabra clave:519.8
Kinetic equations
Difussion equations
Positivity preserving schemes
Stochastic models
Investigación operativa (Matemáticas)
Procesos estocásticos
1207 Investigación Operativa
1208.08 Procesos Estocásticos
Descripción
Sumario:Angiogenesis processes including the effect of stochastic branching and spread of blood vessels can be described coupling a (nonlocal in time) integrodifferential kinetic equation of Fokker-Planck type with a diffusion equation for the angiogenic factor. Well posedness studies underline the importance of preserving positivity when constructing approximate solutions. We devise order one positivity preserving schemes for a reduced model and show that soliton-like asymptotic solutions are correctly captured. We also find good agreement with the original stochastic model from which the deterministic kinetic equations are derived working with ensemble averages. Higher order positivity preserving schemes can be devised combining WENO and SSP procedures.