Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres

20 páginas. -- The final version is available at http://www.elsevier.com

Detalles Bibliográficos
Autores: Balsera, Mónica, Buchanan, Bob B.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/217624
Acceso en línea:http://hdl.handle.net/10261/217624
Access Level:acceso abierto
Palabra clave:Thioredoxin
Redox regulation
Oxidative stress
Disulfide
Thioredoxin reductase
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spelling Evolution of the thioredoxin system as a step enabling adaptation to oxidative stresBalsera, MónicaBuchanan, Bob B.ThioredoxinRedox regulationOxidative stressDisulfideThioredoxin reductase20 páginas. -- The final version is available at http://www.elsevier.comThioredoxins (Trxs) are low-molecular-weight proteins that participate in the reduction of target enzymes. Trxs contain a redox-active disulfide bond, in the form of a WCGPC amino acid sequence motif, that enables them to perform dithiol-disulfide exchange reactions with oxidized protein substrates. Widely distributed across the three domains of life, Trxs form an evolutionarily conserved family of ancient origin. Thioredoxin reductases (TRs) are enzymes that reduce Trxs. According to their evolutionary history, TRs have diverged, thereby leading to the emergence of variants of the enzyme that in combination with different types of Trxs meet the needs of the cell. In addition to participating in the regulation of metabolism and defense against oxidative stress, Trxs respond to environmental signals—an ability that developed early in evolution. Redox regulation of proteins targeted by Trx is accomplished with a pair of redox-active cysteines located in strategic positions on the polypeptide chain to enable reversible oxidative changes that result in structural and functional modifications target proteins. In this review, we present a general overview of the thioredoxin system and describe recent structural studies on the diversity of its components.MB acknowledges financial support from the Spanish Ministerio de Ciencia, Innovación y Universidades [Project Reference BFU2016_80343-P]Peer reviewedElsevierMinisterio de Economía y Competitividad (España)Balsera, Mónica [0000-0002-5586-6050]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/217624reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-80343-Phttps://doi.org/10.1016/j.freeradbiomed.2019.03.003Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2176242026-05-22T06:33:51Z
dc.title.none.fl_str_mv Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres
title Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres
spellingShingle Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres
Balsera, Mónica
Thioredoxin
Redox regulation
Oxidative stress
Disulfide
Thioredoxin reductase
title_short Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres
title_full Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres
title_fullStr Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres
title_full_unstemmed Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres
title_sort Evolution of the thioredoxin system as a step enabling adaptation to oxidative stres
dc.creator.none.fl_str_mv Balsera, Mónica
Buchanan, Bob B.
author Balsera, Mónica
author_facet Balsera, Mónica
Buchanan, Bob B.
author_role author
author2 Buchanan, Bob B.
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Balsera, Mónica [0000-0002-5586-6050]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Thioredoxin
Redox regulation
Oxidative stress
Disulfide
Thioredoxin reductase
topic Thioredoxin
Redox regulation
Oxidative stress
Disulfide
Thioredoxin reductase
description 20 páginas. -- The final version is available at http://www.elsevier.com
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/217624
url http://hdl.handle.net/10261/217624
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-80343-P
https://doi.org/10.1016/j.freeradbiomed.2019.03.003
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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