Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients

Factors associated with a successful outcome upon nucleos(t)ide analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients have yet to be clarified. The objective of this study was to analyse the HBV-specific T cell response, in parallel with peripheral and intrahepatic...

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Detalhes bibliográficos
Autores: García-López, Mireia, Lens, Sabela|||0000-0003-4900-411X, Pallett, Laura J., Testoni, Barbara, Rodríguez-Tajes, Sergio|||0000-0002-3189-7557, Mariño, Zoe|||0000-0001-6321-9534, Bartres, Concepció, García-Pras, Ester, Leonel, Thais, Perpiñán, Elena, Lozano, Juan José, Rodríguez Frías, Francisco|||0000-0002-9128-7013, Koutsoudakis, George, Zoulim, Fabien, Maini, Mala K., Forns, Xavier|||0000-0002-8188-1764, Pérez-Del-Pulgar, Sofía
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:240174
Acesso em linha:https://ddd.uab.cat/record/240174
https://dx.doi.org/urn:doi:10.1016/j.jhep.2020.11.043
Access Level:acceso abierto
Palavra-chave:Hepatitis B virus
Chronic hepatitis B
Nucleos(t)ide analogue
Antiviral therapy discontinuation
HBsAg
HBcrAg
Covalently closed circular DNA
HBV-RNA
Immune response
HBV-Specific T cells
Descrição
Resumo:Factors associated with a successful outcome upon nucleos(t)ide analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients have yet to be clarified. The objective of this study was to analyse the HBV-specific T cell response, in parallel with peripheral and intrahepatic viral parameters, in patients undergoing NA discontinuation. Twenty-seven patients without cirrhosis with HBeAg-negative CHB with complete viral suppression (.

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