IGF-1 and IGFBP-3 in inflammatory cachexia
Inflammation induces a wide response of the neuroendocrine system, which leads to mod-ifications in all the endocrine axes. The hypothalamic–growth hormone (GH)–insulin-like growth factor-1 (IGF-1) axis is deeply affected by inflammation, its response being characterized by GH resistance and a decre...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/717045 |
| Acceso en línea: | http://hdl.handle.net/10486/717045 https://dx.doi.org/10.3390/ijms22179469 |
| Access Level: | acceso abierto |
| Palabra clave: | cachexia cytokines GH glucocorticoids IGF-1 IGFBP-3 inflammation muscle wasting nitric oxide sepsis Medicina |
| Sumario: | Inflammation induces a wide response of the neuroendocrine system, which leads to mod-ifications in all the endocrine axes. The hypothalamic–growth hormone (GH)–insulin-like growth factor-1 (IGF-1) axis is deeply affected by inflammation, its response being characterized by GH resistance and a decrease in circulating levels of IGF-1. The endocrine and metabolic responses to inflammation allow the organism to survive. However, in chronic inflammatory conditions, the inhibition of the hypothalamic–GH–IGF-1 axis contributes to the catabolic process, with skeletal muscle atrophy and cachexia. Here, we review the changes in pituitary GH secretion, IGF-1, and IGF-1 binding protein-3 (IGFBP-3), as well as the mechanism that mediated those responses. The contri-bution of GH and IGF-1 to muscle wasting during inflammation has also been analyzed |
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