Taxane-induced Peripheral Neurotoxicity

Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule asse...

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Detalles Bibliográficos
Autores: Velasco, Roser, Bruna, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126095
Acceso en línea:https://hdl.handle.net/2445/126095
Access Level:acceso abierto
Palabra clave:Quimioteràpia
Neurotoxicologia
Chemotherapy
Neurotoxicology
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spelling Taxane-induced Peripheral NeurotoxicityVelasco, RoserBruna, JordiQuimioteràpiaNeurotoxicologiaChemotherapyNeurotoxicologyTaxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the major non-hematological adverse effect of taxane, often manifested as painful neuropathy experienced during treatment, and it is sometimes irreversible. Unfortunately, taxane-induced neurotoxicity is an uncertainty prior to the initiation of treatment. The present review aims to dissect current knowledge on real incidence, underlying pathophysiology, clinical features and predisposing factors related with the development of taxane-induced neuropathy.Mdpi Ag2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126095Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/toxics3020152Toxics, 2015, vol. 3, num. 2, p. 152-169https://doi.org/10.3390/toxics3020152cc by (c) Velasco, Roser; Bruna, Jordi, 2015http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1260952026-05-27T06:46:51Z
dc.title.none.fl_str_mv Taxane-induced Peripheral Neurotoxicity
title Taxane-induced Peripheral Neurotoxicity
spellingShingle Taxane-induced Peripheral Neurotoxicity
Velasco, Roser
Quimioteràpia
Neurotoxicologia
Chemotherapy
Neurotoxicology
title_short Taxane-induced Peripheral Neurotoxicity
title_full Taxane-induced Peripheral Neurotoxicity
title_fullStr Taxane-induced Peripheral Neurotoxicity
title_full_unstemmed Taxane-induced Peripheral Neurotoxicity
title_sort Taxane-induced Peripheral Neurotoxicity
dc.creator.none.fl_str_mv Velasco, Roser
Bruna, Jordi
author Velasco, Roser
author_facet Velasco, Roser
Bruna, Jordi
author_role author
author2 Bruna, Jordi
author2_role author
dc.subject.none.fl_str_mv Quimioteràpia
Neurotoxicologia
Chemotherapy
Neurotoxicology
topic Quimioteràpia
Neurotoxicologia
Chemotherapy
Neurotoxicology
description Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the major non-hematological adverse effect of taxane, often manifested as painful neuropathy experienced during treatment, and it is sometimes irreversible. Unfortunately, taxane-induced neurotoxicity is an uncertainty prior to the initiation of treatment. The present review aims to dissect current knowledge on real incidence, underlying pathophysiology, clinical features and predisposing factors related with the development of taxane-induced neuropathy.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126095
url https://hdl.handle.net/2445/126095
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/toxics3020152
Toxics, 2015, vol. 3, num. 2, p. 152-169
https://doi.org/10.3390/toxics3020152
dc.rights.none.fl_str_mv cc by (c) Velasco, Roser; Bruna, Jordi, 2015
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Velasco, Roser; Bruna, Jordi, 2015
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mdpi Ag
publisher.none.fl_str_mv Mdpi Ag
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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