Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study

Background & aims: Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within...

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Autores: Molina Montes, Esther, Rodríguez Barranco, Miguel, Alcalá Santiago, Ángela, Gálvez Navas, José María, Huerta Castaño, José María, Amiano, Pilar, Lasheras, Cristina, Moreno Iribas, Conchi, Jiménez Zabala, Ana, Chirlaque, María Dolores, Gasque, Alba, Luján Barroso, Leila, Agudo, Antonio, Jakszyn, Paula, Ramón Quirós, José, Sánchez Pérez, María José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/222034
Acceso en línea:https://hdl.handle.net/2445/222034
Access Level:acceso abierto
Palabra clave:Nutrició
Ritmes circadiaris
Metabolisme
Càncer
Nutrition
Circadian rhythms
Metabolism
Cancer
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spelling Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet studyMolina Montes, EstherRodríguez Barranco, MiguelAlcalá Santiago, ÁngelaGálvez Navas, José MaríaHuerta Castaño, José MaríaAmiano, PilarLasheras, CristinaMoreno Iribas, ConchiJiménez Zabala, AnaChirlaque, María DoloresGasque, AlbaLuján Barroso, LeilaAgudo, AntonioJakszyn, PaulaRamón Quirós, JoséSánchez Pérez, María JoséNutricióRitmes circadiarisMetabolismeCàncerNutritionCircadian rhythmsMetabolismCancerBackground & aims: Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study. Methods: The study population comprised 3,183 subjects with information on diet and twelve genetic variants of six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). The associations between the variants with chrononutrition variables (macronutrients and serving sizes of each meal) were evaluated using linear regression, considering an additive genetic model, and adjusting for sex, age and center, among others. The beta coefficients, 95 % confidence intervals (CI), and p-values corrected for multiple comparisons were estimated. A genetic risk score (GRS) that was associated to the evening/late chronotype as well as overweight/obesity in a previous study, the chronotype-GRS, was tested for its association with chrononutrition variables. Results: The nutritional profile of the diet differed according to the individual's chronotype, with evening/late chronotypes exhibiting an unbalanced intake during breakfast and dinner compared to the intermediate and early chronotypes (e.g., percentage of fats consumed at breakfast relative to the total fat intake: 13 % and 9 %, respectively). However, significant differences were not encountered by the chronotype-GRS. In multivariate analyses, individual associations between the genetic variants and the nutrients revealed some nominal associations (e.g., rs1801260 and rs2070062 with carbohydrates at breakfast: beta = -0.06 to 0.08). Higher scorings of the chronotype-GRS were inversely associated with the intake of proteins and carbohydrates (beta = -0.46 and -0.41; nominal p-value<0.006; corrected = 0.25) during breakfast. Also, there was an inverse association between the chronotype-GRS and the breakfast's portion size (beta = -0.3; nominal p-value = 0.03; corrected = 0.1). Conclusions: Genetic susceptibility to an evening-like chronotype prone to overweight/obesity seems to be associated with a smaller serving size during breakfast, with lower protein and carbohydrate content. (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Elsevier BV2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/222034Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.clnu.2025.04.023Clinical Nutrition, 2025, vol. 49, p. 165-177https://doi.org/10.1016/j.clnu.2025.04.023cc-by (c) Molina Montes et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2220342026-05-27T06:46:51Z
dc.title.none.fl_str_mv Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
spellingShingle Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
Molina Montes, Esther
Nutrició
Ritmes circadiaris
Metabolisme
Càncer
Nutrition
Circadian rhythms
Metabolism
Cancer
title_short Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title_full Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title_fullStr Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title_full_unstemmed Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title_sort Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
dc.creator.none.fl_str_mv Molina Montes, Esther
Rodríguez Barranco, Miguel
Alcalá Santiago, Ángela
Gálvez Navas, José María
Huerta Castaño, José María
Amiano, Pilar
Lasheras, Cristina
Moreno Iribas, Conchi
Jiménez Zabala, Ana
Chirlaque, María Dolores
Gasque, Alba
Luján Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Ramón Quirós, José
Sánchez Pérez, María José
author Molina Montes, Esther
author_facet Molina Montes, Esther
Rodríguez Barranco, Miguel
Alcalá Santiago, Ángela
Gálvez Navas, José María
Huerta Castaño, José María
Amiano, Pilar
Lasheras, Cristina
Moreno Iribas, Conchi
Jiménez Zabala, Ana
Chirlaque, María Dolores
Gasque, Alba
Luján Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Ramón Quirós, José
Sánchez Pérez, María José
author_role author
author2 Rodríguez Barranco, Miguel
Alcalá Santiago, Ángela
Gálvez Navas, José María
Huerta Castaño, José María
Amiano, Pilar
Lasheras, Cristina
Moreno Iribas, Conchi
Jiménez Zabala, Ana
Chirlaque, María Dolores
Gasque, Alba
Luján Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Ramón Quirós, José
Sánchez Pérez, María José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Nutrició
Ritmes circadiaris
Metabolisme
Càncer
Nutrition
Circadian rhythms
Metabolism
Cancer
topic Nutrició
Ritmes circadiaris
Metabolisme
Càncer
Nutrition
Circadian rhythms
Metabolism
Cancer
description Background & aims: Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study. Methods: The study population comprised 3,183 subjects with information on diet and twelve genetic variants of six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). The associations between the variants with chrononutrition variables (macronutrients and serving sizes of each meal) were evaluated using linear regression, considering an additive genetic model, and adjusting for sex, age and center, among others. The beta coefficients, 95 % confidence intervals (CI), and p-values corrected for multiple comparisons were estimated. A genetic risk score (GRS) that was associated to the evening/late chronotype as well as overweight/obesity in a previous study, the chronotype-GRS, was tested for its association with chrononutrition variables. Results: The nutritional profile of the diet differed according to the individual's chronotype, with evening/late chronotypes exhibiting an unbalanced intake during breakfast and dinner compared to the intermediate and early chronotypes (e.g., percentage of fats consumed at breakfast relative to the total fat intake: 13 % and 9 %, respectively). However, significant differences were not encountered by the chronotype-GRS. In multivariate analyses, individual associations between the genetic variants and the nutrients revealed some nominal associations (e.g., rs1801260 and rs2070062 with carbohydrates at breakfast: beta = -0.06 to 0.08). Higher scorings of the chronotype-GRS were inversely associated with the intake of proteins and carbohydrates (beta = -0.46 and -0.41; nominal p-value<0.006; corrected = 0.25) during breakfast. Also, there was an inverse association between the chronotype-GRS and the breakfast's portion size (beta = -0.3; nominal p-value = 0.03; corrected = 0.1). Conclusions: Genetic susceptibility to an evening-like chronotype prone to overweight/obesity seems to be associated with a smaller serving size during breakfast, with lower protein and carbohydrate content. (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222034
url https://hdl.handle.net/2445/222034
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.clnu.2025.04.023
Clinical Nutrition, 2025, vol. 49, p. 165-177
https://doi.org/10.1016/j.clnu.2025.04.023
dc.rights.none.fl_str_mv cc-by (c) Molina Montes et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Molina Montes et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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