Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease

Objective: Patients with Parkinson disease (PD) and mild cognitive impairment (MCI) are vulnerable to dementia and frequently experience memory deficits. This could be the result of dopamine dysfunction in corticostriatal networks (salience, central executive networks, and striatum) and/or the media...

Descripción completa

Detalles Bibliográficos
Autores: Christopher, Leigh, Duff-Canning, Sarah, Koshimori, Yuko, Segura i Fàbregas, Bàrbara, Boileau, Isabelle, Chen, Robert, Lang, Anthony E., Houle, Sylvain, Rusjan, Pablo, Strafella, Antonio P.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/128142
Acceso en línea:https://hdl.handle.net/2445/128142
Access Level:acceso abierto
Palabra clave:Malaltia de Parkinson
Dopamina
Parkinson's disease
Dopamine
id ES_0a42bcfa68c83af276dc4db7fdc3cba3
oai_identifier_str oai:recercat.cat:2445/128142
network_acronym_str ES
network_name_str España
repository_id_str
spelling Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson diseaseChristopher, LeighDuff-Canning, SarahKoshimori, YukoSegura i Fàbregas, BàrbaraBoileau, IsabelleChen, RobertLang, Anthony E.Houle, SylvainRusjan, PabloStrafella, Antonio P.Malaltia de ParkinsonDopaminaParkinson's diseaseDopamineObjective: Patients with Parkinson disease (PD) and mild cognitive impairment (MCI) are vulnerable to dementia and frequently experience memory deficits. This could be the result of dopamine dysfunction in corticostriatal networks (salience, central executive networks, and striatum) and/or the medial temporal lobe. Our aim was to investigate whether dopamine dysfunction in these regions contributes to memory impairment in PD. Methods: We used positron emission tomography imaging to compare D2 receptor availability in the cortex and striatal (limbic and associative) dopamine neuron integrity in 4 groups: memory‐impaired PD (amnestic MCI; n = 9), PD with nonamnestic MCI (n = 10), PD without MCI (n = 11), and healthy controls (n = 14). Subjects were administered a full neuropsychological test battery for cognitive performance. Results: Memory‐impaired patients demonstrated more significant reductions in D2 receptor binding in the salience network (insular cortex and anterior cingulate cortex [ACC] and the right parahippocampal gyrus [PHG]) compared to healthy controls and patients with no MCI. They also presented reductions in the right insula and right ACC compared to nonamnestic MCI patients. D2 levels were correlated with memory performance in the right PHG and left insula of amnestic patients and with executive performance in the bilateral insula and left ACC of all MCI patients. Associative striatal dopamine denervation was significant in all PD patients. Interpretation: Dopaminergic differences in the salience network and the medial temporal lobe contribute to memory impairment in PD. Furthermore, these findings indicate the vulnerability of the salience network in PD and its potential role in memory and executive dysfunction.Wiley-Liss2019201920142019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion-188 p.application/pdfhttps://hdl.handle.net/2445/128142Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1002/ana.24323Annals of Neurology, 2014, vol. 77, num. 2, p. 269-80https://doi.org/10.1002/ana.24323(c) American Neurological Association, 2014info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1281422026-05-29T05:05:01Z
dc.title.none.fl_str_mv Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
title Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
spellingShingle Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
Christopher, Leigh
Malaltia de Parkinson
Dopamina
Parkinson's disease
Dopamine
title_short Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
title_full Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
title_fullStr Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
title_full_unstemmed Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
title_sort Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
dc.creator.none.fl_str_mv Christopher, Leigh
Duff-Canning, Sarah
Koshimori, Yuko
Segura i Fàbregas, Bàrbara
Boileau, Isabelle
Chen, Robert
Lang, Anthony E.
Houle, Sylvain
Rusjan, Pablo
Strafella, Antonio P.
author Christopher, Leigh
author_facet Christopher, Leigh
Duff-Canning, Sarah
Koshimori, Yuko
Segura i Fàbregas, Bàrbara
Boileau, Isabelle
Chen, Robert
Lang, Anthony E.
Houle, Sylvain
Rusjan, Pablo
Strafella, Antonio P.
author_role author
author2 Duff-Canning, Sarah
Koshimori, Yuko
Segura i Fàbregas, Bàrbara
Boileau, Isabelle
Chen, Robert
Lang, Anthony E.
Houle, Sylvain
Rusjan, Pablo
Strafella, Antonio P.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Parkinson
Dopamina
Parkinson's disease
Dopamine
topic Malaltia de Parkinson
Dopamina
Parkinson's disease
Dopamine
description Objective: Patients with Parkinson disease (PD) and mild cognitive impairment (MCI) are vulnerable to dementia and frequently experience memory deficits. This could be the result of dopamine dysfunction in corticostriatal networks (salience, central executive networks, and striatum) and/or the medial temporal lobe. Our aim was to investigate whether dopamine dysfunction in these regions contributes to memory impairment in PD. Methods: We used positron emission tomography imaging to compare D2 receptor availability in the cortex and striatal (limbic and associative) dopamine neuron integrity in 4 groups: memory‐impaired PD (amnestic MCI; n = 9), PD with nonamnestic MCI (n = 10), PD without MCI (n = 11), and healthy controls (n = 14). Subjects were administered a full neuropsychological test battery for cognitive performance. Results: Memory‐impaired patients demonstrated more significant reductions in D2 receptor binding in the salience network (insular cortex and anterior cingulate cortex [ACC] and the right parahippocampal gyrus [PHG]) compared to healthy controls and patients with no MCI. They also presented reductions in the right insula and right ACC compared to nonamnestic MCI patients. D2 levels were correlated with memory performance in the right PHG and left insula of amnestic patients and with executive performance in the bilateral insula and left ACC of all MCI patients. Associative striatal dopamine denervation was significant in all PD patients. Interpretation: Dopaminergic differences in the salience network and the medial temporal lobe contribute to memory impairment in PD. Furthermore, these findings indicate the vulnerability of the salience network in PD and its potential role in memory and executive dysfunction.
publishDate 2014
dc.date.none.fl_str_mv 2014
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/128142
url https://hdl.handle.net/2445/128142
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/ana.24323
Annals of Neurology, 2014, vol. 77, num. 2, p. 269-80
https://doi.org/10.1002/ana.24323
dc.rights.none.fl_str_mv (c) American Neurological Association, 2014
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Neurological Association, 2014
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -188 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley-Liss
publisher.none.fl_str_mv Wiley-Liss
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403153627086848
score 15.812429

Similares en LA Referencia