Monitoring Alzheimer's disease via ultraweak photon emission

In an innovative experiment, we detected ultraweak photon emission (UPE) from the hippocampus of male rat brains and found significant correlations between Alzheimer's disease (AD), memory decline, oxidative stress, and UPE intensity. These findings may open up novel methods for screening, dete...

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Authors: Sefati, N., Esmaeilpour, T., Salari, V., Zarifkar, A., Dehghani, F., Ghaffari, M.K., Zadeh-Haghighi, H., Császár, N., Bókkon, I., Rodrigues, S., Oblak, D.
Format: article
Status:Versión aceptada para publicación
Publication Date:2024
Country:España
Institution:Basque Center for Applied Mathematics (BCAM)
Repository:BIRD. BCAM's Institutional Repository Data
OAI Identifier:oai:bird.bcamath.org:20.500.11824/1775
Online Access:http://hdl.handle.net/20.500.11824/1775
Access Level:Open access
Keyword:Neuroscience
Physics
Techniques in neuroscience
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spelling Monitoring Alzheimer's disease via ultraweak photon emissionSefati, N.Esmaeilpour, T.Salari, V.Zarifkar, A.Dehghani, F.Ghaffari, M.K.Zadeh-Haghighi, H.Császár, N.Bókkon, I.Rodrigues, S.Oblak, D.NeurosciencePhysicsTechniques in neuroscienceIn an innovative experiment, we detected ultraweak photon emission (UPE) from the hippocampus of male rat brains and found significant correlations between Alzheimer's disease (AD), memory decline, oxidative stress, and UPE intensity. These findings may open up novel methods for screening, detecting, diagnosing, and classifying neurodegenerative diseases, particularly AD. The study suggests that UPE from the brain's neural tissue can serve as a valuable indicator. It also proposes the development of a minimally invasive brain-computer interface (BCI) photonic chip for monitoring and diagnosing AD, offering high spatiotemporal resolution of brain activity. The study used a rodent model of sporadic AD, demonstrating that STZ-induced sAD resulted in increased hippocampal UPE, which was associated with oxidative stress. Treatment with donepezil reduced UPE and improved oxidative stress. These findings support the potential utility of UPE as a screening and diagnostic tool for AD and other neurodegenerative diseases.RTI2018-093860-B-C21 funded by (AEI/FEDER, UE) and acronym ‘‘MathNEURO’’; grant (No. 22112) from Shiraz University of Medical Sciences, Shiraz, Iran; Natural Sciences and Engineering Research Council of Canada (NSERC) of Canada, the National Research Council (NRC) of Canada, and the New Frontiers in Research Fund (NFRF) a program by the Social Sciences and Humanities Research Council (SSHRC), Canada.202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/20.500.11824/1775reponame:BIRD. BCAM's Institutional Repository Datainstname:Basque Center for Applied Mathematics (BCAM)Ingléshttps://www.cell.com/iscience/pdf/S2589-0042(23)02821-3.pdfinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001142-Sinfo:eu-repo/grantAgreement/Gobierno Vasco/BERC/BERC.2022-2025Reconocimiento-NoComercial-CompartirIgual 3.0 Españahttp://creativecommons.org/licenses/by-nc-sa/3.0/es/info:eu-repo/semantics/openAccessoai:bird.bcamath.org:20.500.11824/17752026-06-19T12:47:47Z
dc.title.none.fl_str_mv Monitoring Alzheimer's disease via ultraweak photon emission
title Monitoring Alzheimer's disease via ultraweak photon emission
spellingShingle Monitoring Alzheimer's disease via ultraweak photon emission
Sefati, N.
Neuroscience
Physics
Techniques in neuroscience
title_short Monitoring Alzheimer's disease via ultraweak photon emission
title_full Monitoring Alzheimer's disease via ultraweak photon emission
title_fullStr Monitoring Alzheimer's disease via ultraweak photon emission
title_full_unstemmed Monitoring Alzheimer's disease via ultraweak photon emission
title_sort Monitoring Alzheimer's disease via ultraweak photon emission
dc.creator.none.fl_str_mv Sefati, N.
Esmaeilpour, T.
Salari, V.
Zarifkar, A.
Dehghani, F.
Ghaffari, M.K.
Zadeh-Haghighi, H.
Császár, N.
Bókkon, I.
Rodrigues, S.
Oblak, D.
author Sefati, N.
author_facet Sefati, N.
Esmaeilpour, T.
Salari, V.
Zarifkar, A.
Dehghani, F.
Ghaffari, M.K.
Zadeh-Haghighi, H.
Császár, N.
Bókkon, I.
Rodrigues, S.
Oblak, D.
author_role author
author2 Esmaeilpour, T.
Salari, V.
Zarifkar, A.
Dehghani, F.
Ghaffari, M.K.
Zadeh-Haghighi, H.
Császár, N.
Bókkon, I.
Rodrigues, S.
Oblak, D.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuroscience
Physics
Techniques in neuroscience
topic Neuroscience
Physics
Techniques in neuroscience
description In an innovative experiment, we detected ultraweak photon emission (UPE) from the hippocampus of male rat brains and found significant correlations between Alzheimer's disease (AD), memory decline, oxidative stress, and UPE intensity. These findings may open up novel methods for screening, detecting, diagnosing, and classifying neurodegenerative diseases, particularly AD. The study suggests that UPE from the brain's neural tissue can serve as a valuable indicator. It also proposes the development of a minimally invasive brain-computer interface (BCI) photonic chip for monitoring and diagnosing AD, offering high spatiotemporal resolution of brain activity. The study used a rodent model of sporadic AD, demonstrating that STZ-induced sAD resulted in increased hippocampal UPE, which was associated with oxidative stress. Treatment with donepezil reduced UPE and improved oxidative stress. These findings support the potential utility of UPE as a screening and diagnostic tool for AD and other neurodegenerative diseases.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.11824/1775
url http://hdl.handle.net/20.500.11824/1775
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.cell.com/iscience/pdf/S2589-0042(23)02821-3.pdf
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001142-S
info:eu-repo/grantAgreement/Gobierno Vasco/BERC/BERC.2022-2025
dc.rights.none.fl_str_mv Reconocimiento-NoComercial-CompartirIgual 3.0 España
http://creativecommons.org/licenses/by-nc-sa/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconocimiento-NoComercial-CompartirIgual 3.0 España
http://creativecommons.org/licenses/by-nc-sa/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:BIRD. BCAM's Institutional Repository Data
instname:Basque Center for Applied Mathematics (BCAM)
instname_str Basque Center for Applied Mathematics (BCAM)
reponame_str BIRD. BCAM's Institutional Repository Data
collection BIRD. BCAM's Institutional Repository Data
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