miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma

[Background] Sorafenib constitutes a suitable treatment alternative for patients with advanced hepatocellular carcinoma (HCC) in whom atezolizumab + bevacizumab therapy is contraindicated. The aim of the study was the identification of a miRNA signature in liquid biopsy related to sorafenib response...

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Detalles Bibliográficos
Autores: Cruz, Patricia de la, Schmid, Tobias, Boix, Loreto, Moreno, Manuela, Sapena, Víctor, Praena-Fernández, Juan Manuel, Castell, Francisco J., Falcón-Pérez, Juan M., Reig, María, Brüne, Bernhard, Gómez-Bravo, Miguel A., Giráldez, Álvaro, Bruix, Jordi, Ferrer-Ríos, María Teresa, Muntané, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/306768
Acceso en línea:http://hdl.handle.net/10261/306768
https://api.elsevier.com/content/abstract/scopus_id/85137938585
Access Level:acceso abierto
Palabra clave:Sorafenib
Extracellular vesicles
Hepatocellular carcinoma
Liquid biopsy
miRNA
Descripción
Sumario:[Background] Sorafenib constitutes a suitable treatment alternative for patients with advanced hepatocellular carcinoma (HCC) in whom atezolizumab + bevacizumab therapy is contraindicated. The aim of the study was the identification of a miRNA signature in liquid biopsy related to sorafenib response.