Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery

The population of naive T cells in the periphery is best described by determining both its T cell receptor diversity, or number of clonotypes, and the sizes of its clonal subsets. In this paper, we make use of a previously introduced mathematical model of naive T cell homeostasis, to study the fate...

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Detalles Bibliográficos
Autores: Artalejo Rodríguez, Jesús Manuel, Gómez-Corral, Antonio, López-García, M., Molina París, C.
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/24603
Acceso en línea:https://hdl.handle.net/20.500.14352/24603
Access Level:acceso abierto
Palabra clave:519.216
Competition
Cross-reactivity
Extinction
Stochastic descriptor
Stochastic univariate birth and death process
T cell homeostasis
TCR diversity.
Procesos estocásticos
1208.08 Procesos Estocásticos
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oai_identifier_str oai:docta.ucm.es:20.500.14352/24603
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spelling Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the peripheryArtalejo Rodríguez, Jesús ManuelGómez-Corral, AntonioLópez-García, M.Molina París, C.519.216CompetitionCross-reactivityExtinctionStochastic descriptorStochastic univariate birth and death processT cell homeostasisTCR diversity.Procesos estocásticos1208.08 Procesos EstocásticosThe population of naive T cells in the periphery is best described by determining both its T cell receptor diversity, or number of clonotypes, and the sizes of its clonal subsets. In this paper, we make use of a previously introduced mathematical model of naive T cell homeostasis, to study the fate and potential of naive T cell clonotypes in the periphery. This is achieved by the introduction of several new stochastic descriptors for a given naive T cell clonotype, such as its maximum clonal size, the time to reach this maximum, the number of proliferation events required to reach this maximum, the rate of contraction of the clonotype during its way to extinction, as well as the time to a given number of proliferation events. Our results show that two fates can be identified for the dynamics of the clonotype: extinction in the short-term if the clonotype experiences too hostile a peripheral environment, or establishment in the periphery in the long-term. In this second case the probability mass function for the maximum clonal size is bimodal, with one mode near one and the other mode far away from it. Our model also indicates that the fate of a recent thymic emigrant (RTE) during its journey in the periphery has a clear stochastic component, where the probability of extinction cannot be neglected, even in a friendly but competitive environment. On the other hand, a greater deterministic behaviour can be expected in the potential size of the clonotype seeded by the RTE in the long-term, once it escapes extinction.SpringerUniversidad Complutense de Madrid20162016-01-0120162016-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/24603reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/246032026-06-02T12:44:21Z
dc.title.none.fl_str_mv Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
title Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
spellingShingle Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
Artalejo Rodríguez, Jesús Manuel
519.216
Competition
Cross-reactivity
Extinction
Stochastic descriptor
Stochastic univariate birth and death process
T cell homeostasis
TCR diversity.
Procesos estocásticos
1208.08 Procesos Estocásticos
title_short Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
title_full Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
title_fullStr Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
title_full_unstemmed Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
title_sort Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
dc.creator.none.fl_str_mv Artalejo Rodríguez, Jesús Manuel
Gómez-Corral, Antonio
López-García, M.
Molina París, C.
author Artalejo Rodríguez, Jesús Manuel
author_facet Artalejo Rodríguez, Jesús Manuel
Gómez-Corral, Antonio
López-García, M.
Molina París, C.
author_role author
author2 Gómez-Corral, Antonio
López-García, M.
Molina París, C.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 519.216
Competition
Cross-reactivity
Extinction
Stochastic descriptor
Stochastic univariate birth and death process
T cell homeostasis
TCR diversity.
Procesos estocásticos
1208.08 Procesos Estocásticos
topic 519.216
Competition
Cross-reactivity
Extinction
Stochastic descriptor
Stochastic univariate birth and death process
T cell homeostasis
TCR diversity.
Procesos estocásticos
1208.08 Procesos Estocásticos
description The population of naive T cells in the periphery is best described by determining both its T cell receptor diversity, or number of clonotypes, and the sizes of its clonal subsets. In this paper, we make use of a previously introduced mathematical model of naive T cell homeostasis, to study the fate and potential of naive T cell clonotypes in the periphery. This is achieved by the introduction of several new stochastic descriptors for a given naive T cell clonotype, such as its maximum clonal size, the time to reach this maximum, the number of proliferation events required to reach this maximum, the rate of contraction of the clonotype during its way to extinction, as well as the time to a given number of proliferation events. Our results show that two fates can be identified for the dynamics of the clonotype: extinction in the short-term if the clonotype experiences too hostile a peripheral environment, or establishment in the periphery in the long-term. In this second case the probability mass function for the maximum clonal size is bimodal, with one mode near one and the other mode far away from it. Our model also indicates that the fate of a recent thymic emigrant (RTE) during its journey in the periphery has a clear stochastic component, where the probability of extinction cannot be neglected, even in a friendly but competitive environment. On the other hand, a greater deterministic behaviour can be expected in the potential size of the clonotype seeded by the RTE in the long-term, once it escapes extinction.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/24603
url https://hdl.handle.net/20.500.14352/24603
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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