Light-Activated Pharmacological Tools for Exploring the Cholinergic System

Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited th...

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Detalhes bibliográficos
Autores: Colleoni, Alessio, Galli, Giulia, Dallanoce, Clelia, Amici, Marco de, Gorostiza Langa, Pablo Ignacio, Matera, Carlo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/221269
Acesso em linha:https://hdl.handle.net/2445/221269
Access Level:acceso abierto
Palavra-chave:Fotofarmacologia
Bioquímica
Receptors colinèrgics
Photopharmacology
Biochemistry
Acetylcholine receptors
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spelling Light-Activated Pharmacological Tools for Exploring the Cholinergic SystemColleoni, AlessioGalli, GiuliaDallanoce, CleliaAmici, Marco deGorostiza Langa, Pablo IgnacioMatera, CarloFotofarmacologiaBioquímicaReceptors colinèrgicsPhotopharmacologyBiochemistryAcetylcholine receptorsCholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to overcome the limitations of traditional drugs using photocleavable or photoswitchable ligands and spatiotemporal patterns of illumination. Spanning from muscarinic and nicotinic modulators to cholinesterase inhibitors, this review explores the development and application of light-activated compounds as tools for unraveling the role of cholinergic signaling in both physiological and pathological contexts, while also paving the way for innovative phototherapeutic approaches.Wiley2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion24 p.application/pdfhttps://hdl.handle.net/2445/221269Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/med.22108Medicinal Research Reviews, 2025https://doi.org/10.1002/med.22108cc-by (c) Colleoni, Alessio et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2212692026-05-29T05:05:01Z
dc.title.none.fl_str_mv Light-Activated Pharmacological Tools for Exploring the Cholinergic System
title Light-Activated Pharmacological Tools for Exploring the Cholinergic System
spellingShingle Light-Activated Pharmacological Tools for Exploring the Cholinergic System
Colleoni, Alessio
Fotofarmacologia
Bioquímica
Receptors colinèrgics
Photopharmacology
Biochemistry
Acetylcholine receptors
title_short Light-Activated Pharmacological Tools for Exploring the Cholinergic System
title_full Light-Activated Pharmacological Tools for Exploring the Cholinergic System
title_fullStr Light-Activated Pharmacological Tools for Exploring the Cholinergic System
title_full_unstemmed Light-Activated Pharmacological Tools for Exploring the Cholinergic System
title_sort Light-Activated Pharmacological Tools for Exploring the Cholinergic System
dc.creator.none.fl_str_mv Colleoni, Alessio
Galli, Giulia
Dallanoce, Clelia
Amici, Marco de
Gorostiza Langa, Pablo Ignacio
Matera, Carlo
author Colleoni, Alessio
author_facet Colleoni, Alessio
Galli, Giulia
Dallanoce, Clelia
Amici, Marco de
Gorostiza Langa, Pablo Ignacio
Matera, Carlo
author_role author
author2 Galli, Giulia
Dallanoce, Clelia
Amici, Marco de
Gorostiza Langa, Pablo Ignacio
Matera, Carlo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Fotofarmacologia
Bioquímica
Receptors colinèrgics
Photopharmacology
Biochemistry
Acetylcholine receptors
topic Fotofarmacologia
Bioquímica
Receptors colinèrgics
Photopharmacology
Biochemistry
Acetylcholine receptors
description Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to overcome the limitations of traditional drugs using photocleavable or photoswitchable ligands and spatiotemporal patterns of illumination. Spanning from muscarinic and nicotinic modulators to cholinesterase inhibitors, this review explores the development and application of light-activated compounds as tools for unraveling the role of cholinergic signaling in both physiological and pathological contexts, while also paving the way for innovative phototherapeutic approaches.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/221269
url https://hdl.handle.net/2445/221269
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/med.22108
Medicinal Research Reviews, 2025
https://doi.org/10.1002/med.22108
dc.rights.none.fl_str_mv cc-by (c) Colleoni, Alessio et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Colleoni, Alessio et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 24 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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