Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.

Martinez-Garcia MA; Campos-Rodriguez F; Nagore E; Martorell A; Rodriguez-Peralto JL; Riveiro-Falkenbach E; Hernandez L; Bañuls J; Arias E; Ortiz P; Cabriada V; Gardeazabal J; Montserrat JM; Carrera C; Corral J; Masa JF; de Terreros JG; Abad J; Boada A; Mediano O; de Eusebio E; Chiner E; Landete P; Mayos M; Fortuño A; Barbé F; Sánchez de la Torre M; Sanchez de la Torre A; Cano I; Gonzalez C; Pérez-Gil A; Gómez-García T; Cullen D; Somoza M; Formigón M; Aizpuru F; Navarro C; Selma-Ferrer MJ; Garcia-Ortega A; de Unamuno B; Almendros I; Farré R; Gozal D; Spanish Sleep Network

Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.

BACKGROUND: Sleep-disordered breathing (SDB) has been associated with a greater incidence and mortality of cancer, although such findings are inconsistent. However, no large studies are currently available to investigate this association in patients with a specific type of cancer. This study seeks t...

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Autores:	Martinez-Garcia MA, Campos-Rodriguez F, Nagore E, Martorell A, Rodriguez-Peralto JL, Riveiro-Falkenbach E, Hernandez L, Bañuls J, Arias E, Ortiz P, Cabriada V, Gardeazabal J, Montserrat JM, Carrera C, Corral J, Masa JF, de Terreros JG, Abad J, Boada A, Mediano O, de Eusebio E, Chiner E, Landete P, Mayos M, Fortuño A, Barbé F, Sánchez de la Torre M, Sanchez de la Torre A, Cano I, Gonzalez C, Pérez-Gil A, Gómez-García T, Cullen D, Somoza M, Formigón M, Aizpuru F, Navarro C, Selma-Ferrer MJ, Garcia-Ortega A, de Unamuno B, Almendros I, Farré R, Gozal D, Spanish Sleep Network
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2018
País:	España
Institución:	Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:	r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:	oai:isabial.fundanetsuite.com:p6208
Acceso en línea:	https://isabial.portalinvestigacion.com/publicaciones6208
Access Level:	acceso abierto
Palabra clave:	Breslow index melanoma aggressiveness sleep apnea sleep-disordered breathing

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spelling	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.Martinez-Garcia MACampos-Rodriguez FNagore EMartorell ARodriguez-Peralto JLRiveiro-Falkenbach EHernandez LBañuls JArias EOrtiz PCabriada VGardeazabal JMontserrat JMCarrera CCorral JMasa JFde Terreros JGAbad JBoada AMediano Ode Eusebio EChiner ELandete PMayos MFortuño ABarbé FSánchez de la Torre MSanchez de la Torre ACano IGonzalez CPérez-Gil AGómez-García TCullen DSomoza MFormigón MAizpuru FNavarro CSelma-Ferrer MJGarcia-Ortega Ade Unamuno BAlmendros IFarré RGozal DSpanish Sleep NetworkBreslow indexmelanoma aggressivenesssleep apneasleep-disordered breathingBACKGROUND: Sleep-disordered breathing (SDB) has been associated with a greater incidence and mortality of cancer, although such findings are inconsistent. However, no large studies are currently available to investigate this association in patients with a specific type of cancer. This study seeks to assess potential relationships between SDB severity and aggressiveness markers of cutaneous melanoma. METHODS: Four hundred and forty-three patients with a diagnosis of melanoma underwent a sleep study within 6 months of diagnosis. General demographics were collected, along with melanoma characteristics and polygraphic parameters consisting of the apnea-hypopnea index (AHI) and indices of both continuous and intermittent night-time oxyhemoglobin desaturation (DI4%). An exploration of independent relationships between SDB and various objective melanoma aggressiveness markers (Breslow index, presence of ulceration, presence of regression, mitotic index, stage of severity, damage to the sentinel lymph, and spreading of the melanoma) was performed. RESULTS: Patients in the upper tertiles of AHI or DI4% were 1.94 (95% CI, 1.14-3.32; P = .022) and 1.93 (95% CI, 1.14-3.26; P = .013) times more likely, respectively, to present with aggressive melanoma (Breslow index > 1 mm) than those in the lowest tertiles of these sleep attributes after adjustment for age, sex, tumor location, and BMI. This association was particularly prominent among patients < 56 years of age with Breslow index > 2 mm. The presence of the additional markers of aggressiveness was also associated with higher AHI and DI4% values. CONCLUSIONS: The severity of SDB was independently associated with greater aggressiveness of cutaneous melanoma, particularly among younger patients.ELSEVIER2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones6208CHESTISSN: 00123692ISSNe: 19313543reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p62082026-06-12T10:20:37Z
dc.title.none.fl_str_mv	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.
title	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.
spellingShingle	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients. Martinez-Garcia MA Breslow index melanoma aggressiveness sleep apnea sleep-disordered breathing
title_short	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.
title_full	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.
title_fullStr	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.
title_full_unstemmed	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.
title_sort	Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.
dc.creator.none.fl_str_mv	Martinez-Garcia MA Campos-Rodriguez F Nagore E Martorell A Rodriguez-Peralto JL Riveiro-Falkenbach E Hernandez L Bañuls J Arias E Ortiz P Cabriada V Gardeazabal J Montserrat JM Carrera C Corral J Masa JF de Terreros JG Abad J Boada A Mediano O de Eusebio E Chiner E Landete P Mayos M Fortuño A Barbé F Sánchez de la Torre M Sanchez de la Torre A Cano I Gonzalez C Pérez-Gil A Gómez-García T Cullen D Somoza M Formigón M Aizpuru F Navarro C Selma-Ferrer MJ Garcia-Ortega A de Unamuno B Almendros I Farré R Gozal D Spanish Sleep Network
author	Martinez-Garcia MA
author_facet	Martinez-Garcia MA Campos-Rodriguez F Nagore E Martorell A Rodriguez-Peralto JL Riveiro-Falkenbach E Hernandez L Bañuls J Arias E Ortiz P Cabriada V Gardeazabal J Montserrat JM Carrera C Corral J Masa JF de Terreros JG Abad J Boada A Mediano O de Eusebio E Chiner E Landete P Mayos M Fortuño A Barbé F Sánchez de la Torre M Sanchez de la Torre A Cano I Gonzalez C Pérez-Gil A Gómez-García T Cullen D Somoza M Formigón M Aizpuru F Navarro C Selma-Ferrer MJ Garcia-Ortega A de Unamuno B Almendros I Farré R Gozal D Spanish Sleep Network
author_role	author
author2	Campos-Rodriguez F Nagore E Martorell A Rodriguez-Peralto JL Riveiro-Falkenbach E Hernandez L Bañuls J Arias E Ortiz P Cabriada V Gardeazabal J Montserrat JM Carrera C Corral J Masa JF de Terreros JG Abad J Boada A Mediano O de Eusebio E Chiner E Landete P Mayos M Fortuño A Barbé F Sánchez de la Torre M Sanchez de la Torre A Cano I Gonzalez C Pérez-Gil A Gómez-García T Cullen D Somoza M Formigón M Aizpuru F Navarro C Selma-Ferrer MJ Garcia-Ortega A de Unamuno B Almendros I Farré R Gozal D Spanish Sleep Network
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Breslow index melanoma aggressiveness sleep apnea sleep-disordered breathing
topic	Breslow index melanoma aggressiveness sleep apnea sleep-disordered breathing
description	BACKGROUND: Sleep-disordered breathing (SDB) has been associated with a greater incidence and mortality of cancer, although such findings are inconsistent. However, no large studies are currently available to investigate this association in patients with a specific type of cancer. This study seeks to assess potential relationships between SDB severity and aggressiveness markers of cutaneous melanoma. METHODS: Four hundred and forty-three patients with a diagnosis of melanoma underwent a sleep study within 6 months of diagnosis. General demographics were collected, along with melanoma characteristics and polygraphic parameters consisting of the apnea-hypopnea index (AHI) and indices of both continuous and intermittent night-time oxyhemoglobin desaturation (DI4%). An exploration of independent relationships between SDB and various objective melanoma aggressiveness markers (Breslow index, presence of ulceration, presence of regression, mitotic index, stage of severity, damage to the sentinel lymph, and spreading of the melanoma) was performed. RESULTS: Patients in the upper tertiles of AHI or DI4% were 1.94 (95% CI, 1.14-3.32; P = .022) and 1.93 (95% CI, 1.14-3.26; P = .013) times more likely, respectively, to present with aggressive melanoma (Breslow index > 1 mm) than those in the lowest tertiles of these sleep attributes after adjustment for age, sex, tumor location, and BMI. This association was particularly prominent among patients < 56 years of age with Breslow index > 2 mm. The presence of the additional markers of aggressiveness was also associated with higher AHI and DI4% values. CONCLUSIONS: The severity of SDB was independently associated with greater aggressiveness of cutaneous melanoma, particularly among younger patients.
publishDate	2018
dc.date.none.fl_str_mv	2018
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://isabial.portalinvestigacion.com/publicaciones6208
url	https://isabial.portalinvestigacion.com/publicaciones6208
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER
publisher.none.fl_str_mv	ELSEVIER
dc.source.none.fl_str_mv	CHEST ISSN: 00123692 ISSNe: 19313543 reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str	Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str	r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection	r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812429

Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.

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