Sleep State Modulates Resting-State Functional Connectivity in Neonates

Published: 17 April 2020

Detalhes bibliográficos
Autores: Wai Lee, Chuen, Blanco, Borja, Dempsey, Laura, Chalia, Maria, Hebden, Jeremy C., Caballero Gaudes, César, Austin, Topun, Cooper, Robert J.
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/42893
Acesso em linha:http://hdl.handle.net/10810/42893
Access Level:acceso abierto
Palavra-chave:resting-state functional connectivity
functional near-infrared spectroscopy
sleep state
neonates
connectome
functional imaging
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spelling Sleep State Modulates Resting-State Functional Connectivity in NeonatesWai Lee, ChuenBlanco, BorjaDempsey, LauraChalia, MariaHebden, Jeremy C.Caballero Gaudes, CésarAustin, TopunCooper, Robert J.resting-state functional connectivityfunctional near-infrared spectroscopysleep stateneonatesconnectomefunctional imagingPublished: 17 April 2020The spontaneous cerebral activity that gives rise to resting-state networks (RSNs) has been extensively studied in infants in recent years. However, the influence of sleep state on the presence of observable RSNs has yet to be formally investigated in the infant population, despite evidence that sleep modulates resting-state functional connectivity in adults. This effect could be extremely important, as most infant neuroimaging studies rely on the neonate to remain asleep throughout data acquisition. In this study, we combine functional near-infrared spectroscopy with electroencephalography to simultaneously monitor sleep state and investigate RSNs in a cohort of healthy term born neonates. During active sleep (AS) and quiet sleep (QS) our newborn neonates show functional connectivity patterns spatially consistent with previously reported RSN structures. Our three independent functional connectivity analyses revealed stronger interhemispheric connectivity during AS than during QS. In turn, within hemisphere short-range functional connectivity seems to be enhanced during QS. These findings underline the importance of sleep state monitoring in the investigation of RSNs.This work was supported by the Medical Research Council (MR/L017490/1), Evelyn Trust (09/26 2013 RTF), EPSRC (EP/N025946/1), and the Basque Government (PRE_2018_2_0154).Frontiers in Neuroscience202020202020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/42893reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléswww.frontiersin.orginfo:eu-repo/semantics/openAccessCopyright © 2020 Lee, Blanco, Dempsey, Chalia, Hebden, Caballero-Gaudes, Austin and Cooper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.oai:addi.ehu.eus:10810/428932026-06-18T09:23:17Z
dc.title.none.fl_str_mv Sleep State Modulates Resting-State Functional Connectivity in Neonates
title Sleep State Modulates Resting-State Functional Connectivity in Neonates
spellingShingle Sleep State Modulates Resting-State Functional Connectivity in Neonates
Wai Lee, Chuen
resting-state functional connectivity
functional near-infrared spectroscopy
sleep state
neonates
connectome
functional imaging
title_short Sleep State Modulates Resting-State Functional Connectivity in Neonates
title_full Sleep State Modulates Resting-State Functional Connectivity in Neonates
title_fullStr Sleep State Modulates Resting-State Functional Connectivity in Neonates
title_full_unstemmed Sleep State Modulates Resting-State Functional Connectivity in Neonates
title_sort Sleep State Modulates Resting-State Functional Connectivity in Neonates
dc.creator.none.fl_str_mv Wai Lee, Chuen
Blanco, Borja
Dempsey, Laura
Chalia, Maria
Hebden, Jeremy C.
Caballero Gaudes, César
Austin, Topun
Cooper, Robert J.
author Wai Lee, Chuen
author_facet Wai Lee, Chuen
Blanco, Borja
Dempsey, Laura
Chalia, Maria
Hebden, Jeremy C.
Caballero Gaudes, César
Austin, Topun
Cooper, Robert J.
author_role author
author2 Blanco, Borja
Dempsey, Laura
Chalia, Maria
Hebden, Jeremy C.
Caballero Gaudes, César
Austin, Topun
Cooper, Robert J.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv resting-state functional connectivity
functional near-infrared spectroscopy
sleep state
neonates
connectome
functional imaging
topic resting-state functional connectivity
functional near-infrared spectroscopy
sleep state
neonates
connectome
functional imaging
description Published: 17 April 2020
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/42893
url http://hdl.handle.net/10810/42893
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv www.frontiersin.org
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers in Neuroscience
publisher.none.fl_str_mv Frontiers in Neuroscience
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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