Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle

12 páginas, 3 tablas, 2 figuras.

Detalles Bibliográficos
Autores: Vázquez, Patricia, Garrido, J. M., Molina, Elena, Geijo, M. V., Gómez, Nieves, Pérez Pérez, Valentín, Sevilla, Iker A., Alonso Hearn, M., Cortés, Adoración, Juste, Ramón A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/113407
Acceso en línea:http://hdl.handle.net/10261/113407
Access Level:acceso abierto
Palabra clave:Bovine paratuberculosis
Immunopathology
Microbiology
Epidemiology
Pathogenesis
Latency
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spelling Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattleVázquez, PatriciaGarrido, J. M.Molina, ElenaGeijo, M. V.Gómez, NievesPérez Pérez, ValentínSevilla, Iker A.Alonso Hearn, M.Cortés, AdoraciónJuste, Ramón A.Bovine paratuberculosisImmunopathologyMicrobiologyEpidemiologyPathogenesisLatency12 páginas, 3 tablas, 2 figuras.Paratuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete classification of paratuberculosis immunopathological types in cattle recognized five categories. In this study, 1031 slaughtered Friesian cattle were submitted to serological, microbiological and pathological examinations with the aim of maximizing the rate of case detection. In most cases, infected animals had minimal lesions and almost no other proof of infection (38.9%), while the more characteristic types with the whole constellation of microbiological and immunological evidences accounted for a lower proportion (7.7%). As these findings in cattle suggest similarities with the epidemiology of tuberculosis in humans, we propose to re-group the original immunopathological types into two broader paratuberculosis epidemio-pathogenic forms or states: latent and patent. The former term would define infections with focal lesions and might constitute an apparent resilience status representing a difficult to detect reservoir of infection whose role could become critical if later immune-compromising factors lead to re-activation. The latter would group those cases with multifocal and diffuse inflammatory lesions with higher mycobacterial load and viability suggestive of a more immediate epidemiological risk. Interestingly, the relative frequency of presentation of each profile varied with age. The proportion of latent forms remained relatively constant between 33.8% and 54.3% through adulthood from 3 years of age, while patent forms were more frequent during the first years of age and tended to decrease among the oldest individuals.This study was funded by a grant (AGL2006-14315-CO2) from the Ministry of Economy and Competitiveness (MINECO) (Spain). Patricia Vazquez was holder of a graduate fellowship award (FPI) (BES-2007-17170) from the Spanish MINECO.Peer reviewedCSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201520152014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/113407reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.5424/sjar/2014124-5978Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1134072026-05-22T06:33:51Z
dc.title.none.fl_str_mv Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle
title Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle
spellingShingle Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle
Vázquez, Patricia
Bovine paratuberculosis
Immunopathology
Microbiology
Epidemiology
Pathogenesis
Latency
title_short Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle
title_full Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle
title_fullStr Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle
title_full_unstemmed Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle
title_sort Latent infections are the most frequent form of paratuberculosis in slaughtered Freisian cattle
dc.creator.none.fl_str_mv Vázquez, Patricia
Garrido, J. M.
Molina, Elena
Geijo, M. V.
Gómez, Nieves
Pérez Pérez, Valentín
Sevilla, Iker A.
Alonso Hearn, M.
Cortés, Adoración
Juste, Ramón A.
author Vázquez, Patricia
author_facet Vázquez, Patricia
Garrido, J. M.
Molina, Elena
Geijo, M. V.
Gómez, Nieves
Pérez Pérez, Valentín
Sevilla, Iker A.
Alonso Hearn, M.
Cortés, Adoración
Juste, Ramón A.
author_role author
author2 Garrido, J. M.
Molina, Elena
Geijo, M. V.
Gómez, Nieves
Pérez Pérez, Valentín
Sevilla, Iker A.
Alonso Hearn, M.
Cortés, Adoración
Juste, Ramón A.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bovine paratuberculosis
Immunopathology
Microbiology
Epidemiology
Pathogenesis
Latency
topic Bovine paratuberculosis
Immunopathology
Microbiology
Epidemiology
Pathogenesis
Latency
description 12 páginas, 3 tablas, 2 figuras.
publishDate 2014
dc.date.none.fl_str_mv 2014
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/113407
url http://hdl.handle.net/10261/113407
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.5424/sjar/2014124-5978
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
publisher.none.fl_str_mv CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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