Understanding blood oxygenation in a microfluidic meander double side membrane contactor

Lung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has b...

ver descrição completa

Detalhes bibliográficos
Autores: Malankowska, Magdalena, Julián, Ignacio, Pellejero, Ismael, Rho, Hoon Suk, Schlautmann, Stefan, Tiggelaar, Roald M., Pina, María del Pilar, Gardeniers, Han, Mallada, Reyes
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Recursos:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/36166
Acesso em linha:https://hdl.handle.net/2454/36166
Access Level:acceso abierto
Palavra-chave:Blood oxygenation
Microfluidic membrane contactor
id ES_09be65ca2ae2db3c7757e5d82e6b81c2
oai_identifier_str oai:academica-e.unavarra.es:2454/36166
network_acronym_str ES
network_name_str España
repository_id_str
spelling Understanding blood oxygenation in a microfluidic meander double side membrane contactorMalankowska, MagdalenaJulián, IgnacioPellejero, IsmaelRho, Hoon SukSchlautmann, StefanTiggelaar, Roald M.Pina, María del PilarGardeniers, HanMallada, ReyesBlood oxygenationMicrofluidic membrane contactorLung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has been selected as reference model to investigate the oxygenation process. The design criteria for the fabricated devices has been to maximize the oxygen saturation level while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. A mathematical model for the oxygen transfer has been developed and validated by the experimental study. The obtained results demonstrate that blood was successfully oxygenated up to approximately 98% of O-2 saturation and that the oxygen transfer rate at 1 mL/min blood flow rate was approximately 92 mL/minm(2). Finally, a sensitivity analysis of the key parameters, i.e. size of the channel, oxygen concentration in the gas phase and oxygen permeation properties of the membrane, is carried out to discuss the performance limits and to settle the guidelines for future developments.The authors would like to acknowledge the financial support from the Government of Aragón and the Education, Audiovisual and Culture Executive Agency (EU-EACEA) within the EUDIME - 'Erasmus Mundus Doctorate in Membrane Engineering' program (FPA 2011-0014, SGA 2012-1719, http://eudime.unical.it). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011 financed by the Instituto de Salud Carlos III with the assistance of the European Regional Development Fund. Authors acknowledge the LMA-INA for offering access to their instruments and expertise.ElsevierInstitute for Advanced Materials and Mathematics - INAMAT22019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2454/36166reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/361662026-06-17T12:41:47Z
dc.title.none.fl_str_mv Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title Understanding blood oxygenation in a microfluidic meander double side membrane contactor
spellingShingle Understanding blood oxygenation in a microfluidic meander double side membrane contactor
Malankowska, Magdalena
Blood oxygenation
Microfluidic membrane contactor
title_short Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title_full Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title_fullStr Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title_full_unstemmed Understanding blood oxygenation in a microfluidic meander double side membrane contactor
title_sort Understanding blood oxygenation in a microfluidic meander double side membrane contactor
dc.creator.none.fl_str_mv Malankowska, Magdalena
Julián, Ignacio
Pellejero, Ismael
Rho, Hoon Suk
Schlautmann, Stefan
Tiggelaar, Roald M.
Pina, María del Pilar
Gardeniers, Han
Mallada, Reyes
author Malankowska, Magdalena
author_facet Malankowska, Magdalena
Julián, Ignacio
Pellejero, Ismael
Rho, Hoon Suk
Schlautmann, Stefan
Tiggelaar, Roald M.
Pina, María del Pilar
Gardeniers, Han
Mallada, Reyes
author_role author
author2 Julián, Ignacio
Pellejero, Ismael
Rho, Hoon Suk
Schlautmann, Stefan
Tiggelaar, Roald M.
Pina, María del Pilar
Gardeniers, Han
Mallada, Reyes
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institute for Advanced Materials and Mathematics - INAMAT2
dc.subject.none.fl_str_mv Blood oxygenation
Microfluidic membrane contactor
topic Blood oxygenation
Microfluidic membrane contactor
description Lung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has been selected as reference model to investigate the oxygenation process. The design criteria for the fabricated devices has been to maximize the oxygen saturation level while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. A mathematical model for the oxygen transfer has been developed and validated by the experimental study. The obtained results demonstrate that blood was successfully oxygenated up to approximately 98% of O-2 saturation and that the oxygen transfer rate at 1 mL/min blood flow rate was approximately 92 mL/minm(2). Finally, a sensitivity analysis of the key parameters, i.e. size of the channel, oxygen concentration in the gas phase and oxygen permeation properties of the membrane, is carried out to discuss the performance limits and to settle the guidelines for future developments.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/36166
url https://hdl.handle.net/2454/36166
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv © 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403123566510080
score 15,811543

Registos relacionados