Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking

Background: Experimental substance use among young people is related to individual factors including personality traits such as impulsivity and sensation seeking, and genetic variations such as single nucleotide polymorphisms (SNPs) in the fatty acid amide hydrolase (FAAH) gene. The objective of thi...

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Detalles Bibliográficos
Autores: Huertas Rodríguez, Evelio, López Moreno, José Antonio, Fernández, Vanessa, Echeverry Alzate, Víctor, Buhler, Kora Mareen Katharina
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/95291
Acceso en línea:https://hdl.handle.net/20.500.14352/95291
Access Level:acceso abierto
Palabra clave:Experimental substance use
Impulsivity
Sensation seeking
rs12075550
FAAH C385A
Psicología (Psicología)
Ciencias Biomédicas
6105 Evaluación y Diagnostico en Psicología
2409 Genética
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spelling Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seekingAsociaciones entre el uso experimental de sustancias, variaciones del gen FAAH, impulsividad y búsqueda de sensacionesHuertas Rodríguez, EvelioLópez Moreno, José AntonioFernández, VanessaEcheverry Alzate, VíctorBuhler, Kora Mareen KatharinaExperimental substance useImpulsivitySensation seekingrs12075550FAAH C385APsicología (Psicología)Ciencias Biomédicas6105 Evaluación y Diagnostico en Psicología2409 GenéticaBackground: Experimental substance use among young people is related to individual factors including personality traits such as impulsivity and sensation seeking, and genetic variations such as single nucleotide polymorphisms (SNPs) in the fatty acid amide hydrolase (FAAH) gene. The objective of this study is to analyze the relationship between these three sets of variables. Methods: Volunteer undergraduate students (N = 861, 76% female, M = 20.7 years) completed an ad hoc questionnaire on variables related to their consumption of alcohol, tobacco, cannabis, synthetic drugs and cocaine. In addition, 591 of them completed the Barratt Impulsiveness Scale-11 (BIS-11) and the Sensation Seeking Scale-V (SSS-V). All participants were genotyped in FAAH C385A SNP and its proxy variant rs12075550. Results: Consistent with previous data, both impulsivity and sensation seeking were associated with most of the variables related to experimental substance use. In addition, we found the first evidence of an association between the rs12075550 SNP and some of these consumption phenotypes. However, no significant association was found between either of the two SNPs and impulsivity or sensation seeking. Conclusions: The results highlight the importance of considering both personality and genetic differences, together with contextual factors, in the analysis of substance useColegio Oficial de Psicólogos del Principado de Asturias / Facultad de Psicología de la Universidad de OviedoUniversidad Complutense de Madrid20192019-05-3020192019-05-30journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/95291reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/952912026-06-02T12:44:21Z
dc.title.none.fl_str_mv Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking
Asociaciones entre el uso experimental de sustancias, variaciones del gen FAAH, impulsividad y búsqueda de sensaciones
title Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking
spellingShingle Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking
Huertas Rodríguez, Evelio
Experimental substance use
Impulsivity
Sensation seeking
rs12075550
FAAH C385A
Psicología (Psicología)
Ciencias Biomédicas
6105 Evaluación y Diagnostico en Psicología
2409 Genética
title_short Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking
title_full Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking
title_fullStr Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking
title_full_unstemmed Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking
title_sort Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking
dc.creator.none.fl_str_mv Huertas Rodríguez, Evelio
López Moreno, José Antonio
Fernández, Vanessa
Echeverry Alzate, Víctor
Buhler, Kora Mareen Katharina
author Huertas Rodríguez, Evelio
author_facet Huertas Rodríguez, Evelio
López Moreno, José Antonio
Fernández, Vanessa
Echeverry Alzate, Víctor
Buhler, Kora Mareen Katharina
author_role author
author2 López Moreno, José Antonio
Fernández, Vanessa
Echeverry Alzate, Víctor
Buhler, Kora Mareen Katharina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Experimental substance use
Impulsivity
Sensation seeking
rs12075550
FAAH C385A
Psicología (Psicología)
Ciencias Biomédicas
6105 Evaluación y Diagnostico en Psicología
2409 Genética
topic Experimental substance use
Impulsivity
Sensation seeking
rs12075550
FAAH C385A
Psicología (Psicología)
Ciencias Biomédicas
6105 Evaluación y Diagnostico en Psicología
2409 Genética
description Background: Experimental substance use among young people is related to individual factors including personality traits such as impulsivity and sensation seeking, and genetic variations such as single nucleotide polymorphisms (SNPs) in the fatty acid amide hydrolase (FAAH) gene. The objective of this study is to analyze the relationship between these three sets of variables. Methods: Volunteer undergraduate students (N = 861, 76% female, M = 20.7 years) completed an ad hoc questionnaire on variables related to their consumption of alcohol, tobacco, cannabis, synthetic drugs and cocaine. In addition, 591 of them completed the Barratt Impulsiveness Scale-11 (BIS-11) and the Sensation Seeking Scale-V (SSS-V). All participants were genotyped in FAAH C385A SNP and its proxy variant rs12075550. Results: Consistent with previous data, both impulsivity and sensation seeking were associated with most of the variables related to experimental substance use. In addition, we found the first evidence of an association between the rs12075550 SNP and some of these consumption phenotypes. However, no significant association was found between either of the two SNPs and impulsivity or sensation seeking. Conclusions: The results highlight the importance of considering both personality and genetic differences, together with contextual factors, in the analysis of substance use
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-05-30
2019
2019-05-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/95291
url https://hdl.handle.net/20.500.14352/95291
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Colegio Oficial de Psicólogos del Principado de Asturias / Facultad de Psicología de la Universidad de Oviedo
publisher.none.fl_str_mv Colegio Oficial de Psicólogos del Principado de Asturias / Facultad de Psicología de la Universidad de Oviedo
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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