Strategies for the Biofunctionalization of Straining Flow Spinning Regenerated Bombyx mori Fibers

High-performance regenerated silkworm (Bombyx mori) silk fibers can be produced efficiently through the straining flow spinning (SFS) technique. In addition to an enhanced biocompatibility that results from the removal of contaminants during the processing of the material, regenerated silk fibers ma...

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Detalles Bibliográficos
Autores: Lozano Picazo, Paloma, Castro Domínguez, Cristina, Bruno, Augusto Luis, Baeza García, Alejandro, Martínez, Adelia S., López, Patricia A., Castro María, Ángela, Lakhal, Yassmin, Montero, Elena, Colchero Paetz, Luis, González Nieto, Daniel, Rojo, Francisco Javier, Panetsos Petrova, Fivos, Ramos Gómez, Milagros, Daza, Rafael, Gañán Calvo, Alfonso M., Elices Calafat, Manuel, Guinea, Gustavo Víctor, Pérez Rigueiro, José
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/87230
Acceso en línea:https://hdl.handle.net/20.500.14352/87230
Access Level:acceso abierto
Palabra clave:539.19
543.426
Silk
Functionalization
Fluorophore
Streptavidin
Biotin
Click chemistry
Química orgánica (Química)
2306.90 Química de Productos Naturales Orgánicos
2306.18 Estructuras de las Moléculas Orgánicas
Descripción
Sumario:High-performance regenerated silkworm (Bombyx mori) silk fibers can be produced efficiently through the straining flow spinning (SFS) technique. In addition to an enhanced biocompatibility that results from the removal of contaminants during the processing of the material, regenerated silk fibers may be functionalized conveniently by using a range of different strategies. In this work, the possibility of implementing various functionalization techniques is explored, including the production of fluorescent fibers that may be tracked when implanted, the combination of the fibers with enzymes to yield fibers with catalytic properties, and the functionalization of the fibers with cell-adhesion motifs to modulate the adherence of different cell lineages to the material. When considered globally, all these techniques are a strong indication not only of the high versatility offered by the functionalization of regenerated fibers in terms of the different chemistries that can be employed, but also on the wide range of applications that can be covered with these functionalized fibers.

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