Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)

Parra-Ramírez, P. (Paola)|||/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23; Martín-Rojas-Marcos, P. (Patricia)|||/items/2952c4f1-d2b5-421b-97f7-c957ee865b04; Paja, M. (Miguel)|||/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9; González-Boillos, M. (Marga)|||/items/14f47f15-0a8b-4767-ab55-ea0aded977ac; Pascual-Corrales, E. (Eider)|||/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73; García-Cano, A.M. (Ana María)|||/items/0c1a6ede-96d1-4153-9998-690a803e2b55; Ruiz-Sanchez, J.G. (Jorge Gabriel)|||/items/ef42b270-6a01-45f8-b044-f27c8fb943bd; Vicente, A. (Almudena)|||/items/9bcf3945-5ab8-4943-867f-7e938ff96513; Gómez-Hoyos, E. (Emilia)|||/items/3b973185-2531-45e0-b301-01991f8c9b77; Ferreira, R. (Rui)|||/items/b81021ab-fad4-49a3-b39a-3cbad7d24d67; García-Sanz, I. (Íñigo)|||/items/79bbd057-5131-4cc5-b7f5-d2895a694b6c; Recasens, M. (Mónica)|||/items/b3281727-5780-40f6-ba02-7fa743c22e40; Pla-Peris, B. (Begoña)|||/items/0fafb02f-80ce-44d2-96a6-d9a07a5e79c4; Barahona-San-Millan, R. (Rebeca)|||/items/527db164-4619-4d85-b926-4b6f24c76bbe; Picón-César, M.J. (María José)|||/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c; Díaz-Guardiola, P. (Patricia)|||/items/958e2021-db10-4964-9ad9-e855e4626ccd; García-González, J.J. (Juan Jesús)|||/items/84363783-7d28-4a0f-a585-963a7d7d7a8a; Perdomo, C. (Carolina)|||/items/5b52d610-d360-40c1-b982-d35dacf46b8b; Manjón, L. (Laura)|||/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f; García-Centeno, R. (Rogelio)|||/items/54f8d799-cb77-4875-b8ef-4f0d06ab0b33; Percovich, J.C. (Juan Carlos)|||/items/53638921-32a6-4d95-ad51-f546c990a590; Rebollo-Román, A. (Angel)|||/items/c80baf90-012b-4651-8d31-25e1356a0694; Gracia-Gimeno, P. (Paola)|||/items/06e007ab-8641-4019-8c96-9afe0fd7aea1; Robles-Lázaro, C. (Cristina)|||/items/b1e66a15-6a19-4e31-8597-a43a0cb04746; Morales, M. (Manuel)|||/items/442af46a-a2ce-42ff-b830-d48b28edbdb6; Hanzu, F. (Felicia)|||/items/18094f90-5b34-4f9f-a644-84baa14d7612; Araujo-Castro, M. (Marta)|||/items/be343957-0b49-450b-9999-b8687cebeba5

Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)

Objective: To compare the presentation and evolution of primary aldosteronism (PA) in the elderly (≥65 years) and young patients (<65 years). Methods: A retrospective multicenter study was performed in 20 Spanish hospitals of PA patients in follow-up between 2018 and 2021. Results: Three hundred...

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Detalles Bibliográficos
Autores:	Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23, Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04, Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9, González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977ac, Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73, García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55, Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bd, Vicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513, Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77, Ferreira, R. (Rui)\|\|\|/items/b81021ab-fad4-49a3-b39a-3cbad7d24d67, García-Sanz, I. (Íñigo)\|\|\|/items/79bbd057-5131-4cc5-b7f5-d2895a694b6c, Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40, Pla-Peris, B. (Begoña)\|\|\|/items/0fafb02f-80ce-44d2-96a6-d9a07a5e79c4, Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbe, Picón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c, Díaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccd, García-González, J.J. (Juan Jesús)\|\|\|/items/84363783-7d28-4a0f-a585-963a7d7d7a8a, Perdomo, C. (Carolina)\|\|\|/items/5b52d610-d360-40c1-b982-d35dacf46b8b, Manjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f, García-Centeno, R. (Rogelio)\|\|\|/items/54f8d799-cb77-4875-b8ef-4f0d06ab0b33, Percovich, J.C. (Juan Carlos)\|\|\|/items/53638921-32a6-4d95-ad51-f546c990a590, Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694, Gracia-Gimeno, P. (Paola)\|\|\|/items/06e007ab-8641-4019-8c96-9afe0fd7aea1, Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746, Morales, M. (Manuel)\|\|\|/items/442af46a-a2ce-42ff-b830-d48b28edbdb6, Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612, Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dnet:dadun_______::14c0a690c1365e4c52dd338bcadf82ae
Acceso en línea:	https://hdl.handle.net/10171/124038
Access Level:	acceso abierto
Palabra clave:	Adrenal venous sampling Adrenalectomy Elderly Primary aldosteronism

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dc.title.none.fl_str_mv	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)
title	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)
spellingShingle	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years) Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23 Adrenal venous sampling Adrenalectomy Elderly Primary aldosteronism
title_short	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)
title_full	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)
title_fullStr	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)
title_full_unstemmed	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)
title_sort	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)
dc.creator.none.fl_str_mv	Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23 Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04 Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9 González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977ac Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73 García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55 Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bd Vicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513 Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77 Ferreira, R. (Rui)\|\|\|/items/b81021ab-fad4-49a3-b39a-3cbad7d24d67 García-Sanz, I. (Íñigo)\|\|\|/items/79bbd057-5131-4cc5-b7f5-d2895a694b6c Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40 Pla-Peris, B. (Begoña)\|\|\|/items/0fafb02f-80ce-44d2-96a6-d9a07a5e79c4 Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbe Picón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c Díaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccd García-González, J.J. (Juan Jesús)\|\|\|/items/84363783-7d28-4a0f-a585-963a7d7d7a8a Perdomo, C. (Carolina)\|\|\|/items/5b52d610-d360-40c1-b982-d35dacf46b8b Manjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f García-Centeno, R. (Rogelio)\|\|\|/items/54f8d799-cb77-4875-b8ef-4f0d06ab0b33 Percovich, J.C. (Juan Carlos)\|\|\|/items/53638921-32a6-4d95-ad51-f546c990a590 Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694 Gracia-Gimeno, P. (Paola)\|\|\|/items/06e007ab-8641-4019-8c96-9afe0fd7aea1 Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746 Morales, M. (Manuel)\|\|\|/items/442af46a-a2ce-42ff-b830-d48b28edbdb6 Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612 Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5
author	Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23
author_facet	Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23 Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04 Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9 González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977ac Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73 García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55 Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bd Vicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513 Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77 Ferreira, R. (Rui)\|\|\|/items/b81021ab-fad4-49a3-b39a-3cbad7d24d67 García-Sanz, I. (Íñigo)\|\|\|/items/79bbd057-5131-4cc5-b7f5-d2895a694b6c Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40 Pla-Peris, B. (Begoña)\|\|\|/items/0fafb02f-80ce-44d2-96a6-d9a07a5e79c4 Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbe Picón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c Díaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccd García-González, J.J. (Juan Jesús)\|\|\|/items/84363783-7d28-4a0f-a585-963a7d7d7a8a Perdomo, C. (Carolina)\|\|\|/items/5b52d610-d360-40c1-b982-d35dacf46b8b Manjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f García-Centeno, R. (Rogelio)\|\|\|/items/54f8d799-cb77-4875-b8ef-4f0d06ab0b33 Percovich, J.C. (Juan Carlos)\|\|\|/items/53638921-32a6-4d95-ad51-f546c990a590 Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694 Gracia-Gimeno, P. (Paola)\|\|\|/items/06e007ab-8641-4019-8c96-9afe0fd7aea1 Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746 Morales, M. (Manuel)\|\|\|/items/442af46a-a2ce-42ff-b830-d48b28edbdb6 Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612 Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5
author_role	author
author2	Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04 Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9 González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977ac Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73 García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55 Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bd Vicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513 Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77 Ferreira, R. (Rui)\|\|\|/items/b81021ab-fad4-49a3-b39a-3cbad7d24d67 García-Sanz, I. (Íñigo)\|\|\|/items/79bbd057-5131-4cc5-b7f5-d2895a694b6c Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40 Pla-Peris, B. (Begoña)\|\|\|/items/0fafb02f-80ce-44d2-96a6-d9a07a5e79c4 Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbe Picón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c Díaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccd García-González, J.J. (Juan Jesús)\|\|\|/items/84363783-7d28-4a0f-a585-963a7d7d7a8a Perdomo, C. (Carolina)\|\|\|/items/5b52d610-d360-40c1-b982-d35dacf46b8b Manjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f García-Centeno, R. (Rogelio)\|\|\|/items/54f8d799-cb77-4875-b8ef-4f0d06ab0b33 Percovich, J.C. (Juan Carlos)\|\|\|/items/53638921-32a6-4d95-ad51-f546c990a590 Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694 Gracia-Gimeno, P. (Paola)\|\|\|/items/06e007ab-8641-4019-8c96-9afe0fd7aea1 Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746 Morales, M. (Manuel)\|\|\|/items/442af46a-a2ce-42ff-b830-d48b28edbdb6 Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612 Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Adrenal venous sampling Adrenalectomy Elderly Primary aldosteronism
topic	Adrenal venous sampling Adrenalectomy Elderly Primary aldosteronism
description	Objective: To compare the presentation and evolution of primary aldosteronism (PA) in the elderly (≥65 years) and young patients (<65 years). Methods: A retrospective multicenter study was performed in 20 Spanish hospitals of PA patients in follow-up between 2018 and 2021. Results: Three hundred fifty-two patients with PA <65 years and 88 patients ≥65 years were included. Older PA patients had a two-fold higher prevalence of type 2 diabetes, dyslipidemia, and cerebrovascular disease, but these differences disappeared after adjusting for hypertension duration. At diagnosis, diastolic blood pressure was lower than in young patients (83.3 ± 11.54 vs 91.6 ± 14.46 mmHg, P < 0.0001). No differences in the rate of overall correct cannulation (56.5% vs 42.3%, P = 0.206) or the diagnosis of unilaterality (76.9% vs 62.5%, P = 0.325) in the adrenal venous sampling (AVS) was observed between the elderly and young groups. However, there was a lower proportion of PA patients who underwent adrenalectomy in the elderly group than in the younger group (22.7% (n = 20) vs 37.5% (n = 132), P = 0.009). Nevertheless, no differences in the rate of postsurgical biochemical (100% (n = 14) vs 92.8% (n = 90), P = 0.299) and hypertension cure (38.6% (n = 51) vs 25.0% (n = 5), P = 0.239) were observed between both groups. Conclusion: Older patients with PA have a worse cardiometabolic profile than young patients with PA that it is related to a longer duration of hypertension. However, the results of the AVS, and adrenalectomy are similar in both groups. Therefore, the management of elderly patients with PA should be based not only on age, but rather on the overall medical, physical, social, and mental characteristics of the patients.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-01-01 2022 2022-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/124038
url	https://hdl.handle.net/10171/124038
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Bioscientifica Ltd
publisher.none.fl_str_mv	Bioscientifica Ltd
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
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collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
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repository.mail.fl_str_mv
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spelling	Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977acPascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bdVicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77Ferreira, R. (Rui)\|\|\|/items/b81021ab-fad4-49a3-b39a-3cbad7d24d67García-Sanz, I. (Íñigo)\|\|\|/items/79bbd057-5131-4cc5-b7f5-d2895a694b6cRecasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40Pla-Peris, B. (Begoña)\|\|\|/items/0fafb02f-80ce-44d2-96a6-d9a07a5e79c4Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbePicón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29cDíaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccdGarcía-González, J.J. (Juan Jesús)\|\|\|/items/84363783-7d28-4a0f-a585-963a7d7d7a8aPerdomo, C. (Carolina)\|\|\|/items/5b52d610-d360-40c1-b982-d35dacf46b8bManjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0fGarcía-Centeno, R. (Rogelio)\|\|\|/items/54f8d799-cb77-4875-b8ef-4f0d06ab0b33Percovich, J.C. (Juan Carlos)\|\|\|/items/53638921-32a6-4d95-ad51-f546c990a590Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694Gracia-Gimeno, P. (Paola)\|\|\|/items/06e007ab-8641-4019-8c96-9afe0fd7aea1Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746Morales, M. (Manuel)\|\|\|/items/442af46a-a2ce-42ff-b830-d48b28edbdb6Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5Adrenal venous samplingAdrenalectomyElderlyPrimary aldosteronismObjective: To compare the presentation and evolution of primary aldosteronism (PA) in the elderly (≥65 years) and young patients (<65 years). Methods: A retrospective multicenter study was performed in 20 Spanish hospitals of PA patients in follow-up between 2018 and 2021. Results: Three hundred fifty-two patients with PA <65 years and 88 patients ≥65 years were included. Older PA patients had a two-fold higher prevalence of type 2 diabetes, dyslipidemia, and cerebrovascular disease, but these differences disappeared after adjusting for hypertension duration. At diagnosis, diastolic blood pressure was lower than in young patients (83.3 ± 11.54 vs 91.6 ± 14.46 mmHg, P < 0.0001). No differences in the rate of overall correct cannulation (56.5% vs 42.3%, P = 0.206) or the diagnosis of unilaterality (76.9% vs 62.5%, P = 0.325) in the adrenal venous sampling (AVS) was observed between the elderly and young groups. However, there was a lower proportion of PA patients who underwent adrenalectomy in the elderly group than in the younger group (22.7% (n = 20) vs 37.5% (n = 132), P = 0.009). Nevertheless, no differences in the rate of postsurgical biochemical (100% (n = 14) vs 92.8% (n = 90), P = 0.299) and hypertension cure (38.6% (n = 51) vs 25.0% (n = 5), P = 0.239) were observed between both groups. Conclusion: Older patients with PA have a worse cardiometabolic profile than young patients with PA that it is related to a longer duration of hypertension. However, the results of the AVS, and adrenalectomy are similar in both groups. Therefore, the management of elderly patients with PA should be based not only on age, but rather on the overall medical, physical, social, and mental characteristics of the patients.Bioscientifica LtdDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/124038reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dnet:dadun_______::14c0a690c1365e4c52dd338bcadf82ae2026-06-21T12:47:57Z
score	15,812429

Differences in the presentation and evolution of primary aldosteronism in elderly (≥65 years) and young patients (<65 years)

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