Expression of MASTL (Greatwall) associates with good prognosis and response to radiotherapy in pharyngeal squamous cell carcinoma

Head and neck squamous cell carcinomas (HNSCCs) are highly heterogeneous in both disease progression and treatment outcome, with hardly any molecular biomarker in clinical practice. Thus, the aim of this study was to investigate the potential prognostic and predictive value of MASTL/Greatwall, a mit...

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Detalles Bibliográficos
Autores: Pozo-Agundo, Esperanza, Álvarez-González, Miguel, Rivera-García, Israel, García-de-la-Fuente, Vanessa, Martino, Alba de, Tejedor, Juan Ramón, Vicente, Juan Carlos de, Rodrigo Tapia, Juan Pablo, García-Pedrero, Juana M., Álvarez-Fernández, Mónica
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/391241
Acceso en línea:http://hdl.handle.net/10261/391241
Access Level:acceso abierto
Palabra clave:MASTL
Prognosis
Head and neck cancer
Radiotherapy
Pharyngeal squamous cell carcinoma
p21
Descripción
Sumario:Head and neck squamous cell carcinomas (HNSCCs) are highly heterogeneous in both disease progression and treatment outcome, with hardly any molecular biomarker in clinical practice. Thus, the aim of this study was to investigate the potential prognostic and predictive value of MASTL/Greatwall, a mitotic kinase also involved in PI3K-mTOR signaling and the DNA damage response, in HNSCC.

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