Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia

Cerebral blood flow (CBF) reflects the rate of delivery of arterial blood to the brain. Since no nutrients, oxygen or water can be stored in the cranial cavity due to space and pressure restrictions, a continuous perfusion of the brain is critical for survival. Anesthetic procedures are known to aff...

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Autores: González Pijuán, Carmen|||0000-0002-8584-8531, García Hernando, Gabriel, Jensen, Erik W., Vallverdú Ferrer, Montserrat|||0000-0002-2031-3261
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/374251
Acceso en línea:https://hdl.handle.net/2117/374251
https://dx.doi.org/10.3389/fnetp.2022.912733
Access Level:acceso abierto
Palabra clave:Electroencephalography
Cerebral circulation
Anesthesia
General anesthesia
Cerebral blood flow
Rheoencephalography
Poincaré plot descriptors
Granger causality
Electroencefalografia
Circulació cerebral
Anestèsia
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anestèsia i reanimació
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spelling Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesiaGonzález Pijuán, Carmen|||0000-0002-8584-8531García Hernando, GabrielJensen, Erik W.Vallverdú Ferrer, Montserrat|||0000-0002-2031-3261ElectroencephalographyCerebral circulationAnesthesiaGeneral anesthesiaCerebral blood flowElectroencephalographyRheoencephalographyPoincaré plot descriptorsGranger causalityElectroencefalografiaCirculació cerebralAnestèsiaÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Anestèsia i reanimacióCerebral blood flow (CBF) reflects the rate of delivery of arterial blood to the brain. Since no nutrients, oxygen or water can be stored in the cranial cavity due to space and pressure restrictions, a continuous perfusion of the brain is critical for survival. Anesthetic procedures are known to affect cerebral hemodynamics, but CBF is only monitored in critical patients due, among others, to the lack of a continuous and affordable bedside monitor for this purpose. A potential solution through bioelectrical impedance technology, also known as rheoencephalography (REG), is proposed, that could fill the existing gap for a low-cost and effective CBF monitoring tool. The underlying hypothesis is that REG signals carry information on CBF that might be recovered by means of the application of advanced signal processing techniques, allowing to track CBF alterations during anesthetic procedures. The analysis of REG signals was based on geometric features extracted from the time domain in the first place, since this is the standard processing strategy for this type of physiological data. Geometric features were tested to distinguish between different anesthetic depths, and they proved to be capable of tracking cerebral hemodynamic changes during anesthesia. Furthermore, an approach based on Poincaré plot features was proposed, where the reconstructed attractors form REG signals showed significant differences between different anesthetic states. This was a key finding, providing an alternative to standard processing of REG signals and supporting the hypothesis that REG signals do carry CBF information. Furthermore, the analysis of cerebral hemodynamics during anesthetic procedures was performed by means of studying causal relationships between global hemodynamics, cerebral hemodynamics and electroencephalogram (EEG) based-parameters. Interactions were detected during anesthetic drug infusion and patient positioning (Trendelenburg positioning and passive leg raise), providing evidence of the causal coupling between hemodynamics and brain activity. The provided alternative of REG signal processing confirmed the hypothesis that REG signals carry information on CBF. The simplicity of the technology, together with its low cost and easily interpretable outcomes, should provide a new opportunity for REG to reach standard clinical practice. Moreover, causal relationships among the hemodynamic physiological signals and brain activity were assessed, suggesting that the inclusion of REG information in depth of anesthesia monitors could be of valuable use to prevent unwanted CBF alterations during anesthetic procedures.Peer ReviewedFrontiers Media SA20222022-08-2920222022-10-11journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/374251https://dx.doi.org/10.3389/fnetp.2022.912733reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3742512026-05-27T15:37:01Z
dc.title.none.fl_str_mv Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia
title Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia
spellingShingle Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia
González Pijuán, Carmen|||0000-0002-8584-8531
Electroencephalography
Cerebral circulation
Anesthesia
General anesthesia
Cerebral blood flow
Electroencephalography
Rheoencephalography
Poincaré plot descriptors
Granger causality
Electroencefalografia
Circulació cerebral
Anestèsia
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anestèsia i reanimació
title_short Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia
title_full Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia
title_fullStr Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia
title_full_unstemmed Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia
title_sort Assessing rheoencephalography dynamics through analysis of the interactions among brain and cardiac networks during general anesthesia
dc.creator.none.fl_str_mv González Pijuán, Carmen|||0000-0002-8584-8531
García Hernando, Gabriel
Jensen, Erik W.
Vallverdú Ferrer, Montserrat|||0000-0002-2031-3261
author González Pijuán, Carmen|||0000-0002-8584-8531
author_facet González Pijuán, Carmen|||0000-0002-8584-8531
García Hernando, Gabriel
Jensen, Erik W.
Vallverdú Ferrer, Montserrat|||0000-0002-2031-3261
author_role author
author2 García Hernando, Gabriel
Jensen, Erik W.
Vallverdú Ferrer, Montserrat|||0000-0002-2031-3261
author2_role author
author
author
dc.subject.none.fl_str_mv Electroencephalography
Cerebral circulation
Anesthesia
General anesthesia
Cerebral blood flow
Electroencephalography
Rheoencephalography
Poincaré plot descriptors
Granger causality
Electroencefalografia
Circulació cerebral
Anestèsia
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anestèsia i reanimació
topic Electroencephalography
Cerebral circulation
Anesthesia
General anesthesia
Cerebral blood flow
Electroencephalography
Rheoencephalography
Poincaré plot descriptors
Granger causality
Electroencefalografia
Circulació cerebral
Anestèsia
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anestèsia i reanimació
description Cerebral blood flow (CBF) reflects the rate of delivery of arterial blood to the brain. Since no nutrients, oxygen or water can be stored in the cranial cavity due to space and pressure restrictions, a continuous perfusion of the brain is critical for survival. Anesthetic procedures are known to affect cerebral hemodynamics, but CBF is only monitored in critical patients due, among others, to the lack of a continuous and affordable bedside monitor for this purpose. A potential solution through bioelectrical impedance technology, also known as rheoencephalography (REG), is proposed, that could fill the existing gap for a low-cost and effective CBF monitoring tool. The underlying hypothesis is that REG signals carry information on CBF that might be recovered by means of the application of advanced signal processing techniques, allowing to track CBF alterations during anesthetic procedures. The analysis of REG signals was based on geometric features extracted from the time domain in the first place, since this is the standard processing strategy for this type of physiological data. Geometric features were tested to distinguish between different anesthetic depths, and they proved to be capable of tracking cerebral hemodynamic changes during anesthesia. Furthermore, an approach based on Poincaré plot features was proposed, where the reconstructed attractors form REG signals showed significant differences between different anesthetic states. This was a key finding, providing an alternative to standard processing of REG signals and supporting the hypothesis that REG signals do carry CBF information. Furthermore, the analysis of cerebral hemodynamics during anesthetic procedures was performed by means of studying causal relationships between global hemodynamics, cerebral hemodynamics and electroencephalogram (EEG) based-parameters. Interactions were detected during anesthetic drug infusion and patient positioning (Trendelenburg positioning and passive leg raise), providing evidence of the causal coupling between hemodynamics and brain activity. The provided alternative of REG signal processing confirmed the hypothesis that REG signals carry information on CBF. The simplicity of the technology, together with its low cost and easily interpretable outcomes, should provide a new opportunity for REG to reach standard clinical practice. Moreover, causal relationships among the hemodynamic physiological signals and brain activity were assessed, suggesting that the inclusion of REG information in depth of anesthesia monitors could be of valuable use to prevent unwanted CBF alterations during anesthetic procedures.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-08-29
2022
2022-10-11
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/374251
https://dx.doi.org/10.3389/fnetp.2022.912733
url https://hdl.handle.net/2117/374251
https://dx.doi.org/10.3389/fnetp.2022.912733
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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