The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia

Nowadays, Alzheimer's disease (AD) is a severe sociological and clinical problem. Since it was first described, there has been a constant increase in its incidence and, for now, there are no effective treatments since current approved medications have only shown short-term symptomatic benefits....

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Autores: Folch, Jaume, Olloquequi, Jordi, Ettcheto Arriola, Miren, Busquets Figueras, Oriol, Sánchez-López, E. (Elena), Cano Fernández, Amanda, Espinosa-Jiménez, Triana, García López, María Luisa, Beas Zárate, Carlos, Casadesús, Gemma, Bulló, Mònica, Auladell i Costa, M. Carme, Camins Espuny, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/158019
Acceso en línea:https://hdl.handle.net/2445/158019
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Receptors d'insulina
Alzheimer's disease
Insulin receptors
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spelling The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's DementiaFolch, JaumeOlloquequi, JordiEttcheto Arriola, MirenBusquets Figueras, OriolSánchez-López, E. (Elena)Cano Fernández, AmandaEspinosa-Jiménez, TrianaGarcía López, María LuisaBeas Zárate, CarlosCasadesús, GemmaBulló, MònicaAuladell i Costa, M. CarmeCamins Espuny, AntoniMalaltia d'AlzheimerReceptors d'insulinaAlzheimer's diseaseInsulin receptorsNowadays, Alzheimer's disease (AD) is a severe sociological and clinical problem. Since it was first described, there has been a constant increase in its incidence and, for now, there are no effective treatments since current approved medications have only shown short-term symptomatic benefits. Therefore, it is imperative to increase efforts in the search for molecules and non-pharmacological strategies that are capable of slowing or stopping the progress of the disease and, ideally, to reverse it. The amyloid cascade hypothesis based on the fundamental role of amyloid has been the central hypothesis in the last 30 years. However, since amyloid-directed treatments have shown no relevant beneficial results other theories have been postulated to explain the origin of the pathology. The brain is a highly metabolically active energy-consuming tissue in the human body. It has an almost complete dependence on the metabolism of glucose and uses most of its energy for synaptic transmission. Thus, alterations on the utilization or availability of glucose may be cause for the appearance of neurodegenerative pathologies like AD. In this review article, the hypothesis known as Type 3 Diabetes (T3D) will be evaluated by summarizing some of the data that has been reported in recent years. According to published research, the adherence over time to low saturated fatty acids diets in the context of the Mediterranean diet would reduce the inflammatory levels in brain, with a decrease in the pro-inflammatory glial activation and mitochondrial oxidative stress. In this situation, the insulin receptor pathway would be able to fine tune the mitochondrial biogenesis in neuronal cells, regulation the adenosine triphosphate/adenosine diphosphate intracellular balance, and becoming a key factor involved in the preservation of the synaptic connexions and neuronal plasticity. In addition, new targets and strategies for the treatment of AD will be considered in this review for their potential as new pharmacological or non-pharmacological approaches.Frontiers Media2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/158019Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fnagi.2019.00236Frontiers in Aging Neuroscience, 2019, vol. 6, p. 11-236https://doi.org/10.3389/fnagi.2019.00236cc-by (c) Folch, Jaume et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1580192026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
title The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
spellingShingle The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
Folch, Jaume
Malaltia d'Alzheimer
Receptors d'insulina
Alzheimer's disease
Insulin receptors
title_short The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
title_full The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
title_fullStr The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
title_full_unstemmed The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
title_sort The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
dc.creator.none.fl_str_mv Folch, Jaume
Olloquequi, Jordi
Ettcheto Arriola, Miren
Busquets Figueras, Oriol
Sánchez-López, E. (Elena)
Cano Fernández, Amanda
Espinosa-Jiménez, Triana
García López, María Luisa
Beas Zárate, Carlos
Casadesús, Gemma
Bulló, Mònica
Auladell i Costa, M. Carme
Camins Espuny, Antoni
author Folch, Jaume
author_facet Folch, Jaume
Olloquequi, Jordi
Ettcheto Arriola, Miren
Busquets Figueras, Oriol
Sánchez-López, E. (Elena)
Cano Fernández, Amanda
Espinosa-Jiménez, Triana
García López, María Luisa
Beas Zárate, Carlos
Casadesús, Gemma
Bulló, Mònica
Auladell i Costa, M. Carme
Camins Espuny, Antoni
author_role author
author2 Olloquequi, Jordi
Ettcheto Arriola, Miren
Busquets Figueras, Oriol
Sánchez-López, E. (Elena)
Cano Fernández, Amanda
Espinosa-Jiménez, Triana
García López, María Luisa
Beas Zárate, Carlos
Casadesús, Gemma
Bulló, Mònica
Auladell i Costa, M. Carme
Camins Espuny, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Receptors d'insulina
Alzheimer's disease
Insulin receptors
topic Malaltia d'Alzheimer
Receptors d'insulina
Alzheimer's disease
Insulin receptors
description Nowadays, Alzheimer's disease (AD) is a severe sociological and clinical problem. Since it was first described, there has been a constant increase in its incidence and, for now, there are no effective treatments since current approved medications have only shown short-term symptomatic benefits. Therefore, it is imperative to increase efforts in the search for molecules and non-pharmacological strategies that are capable of slowing or stopping the progress of the disease and, ideally, to reverse it. The amyloid cascade hypothesis based on the fundamental role of amyloid has been the central hypothesis in the last 30 years. However, since amyloid-directed treatments have shown no relevant beneficial results other theories have been postulated to explain the origin of the pathology. The brain is a highly metabolically active energy-consuming tissue in the human body. It has an almost complete dependence on the metabolism of glucose and uses most of its energy for synaptic transmission. Thus, alterations on the utilization or availability of glucose may be cause for the appearance of neurodegenerative pathologies like AD. In this review article, the hypothesis known as Type 3 Diabetes (T3D) will be evaluated by summarizing some of the data that has been reported in recent years. According to published research, the adherence over time to low saturated fatty acids diets in the context of the Mediterranean diet would reduce the inflammatory levels in brain, with a decrease in the pro-inflammatory glial activation and mitochondrial oxidative stress. In this situation, the insulin receptor pathway would be able to fine tune the mitochondrial biogenesis in neuronal cells, regulation the adenosine triphosphate/adenosine diphosphate intracellular balance, and becoming a key factor involved in the preservation of the synaptic connexions and neuronal plasticity. In addition, new targets and strategies for the treatment of AD will be considered in this review for their potential as new pharmacological or non-pharmacological approaches.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/158019
url https://hdl.handle.net/2445/158019
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2019.00236
Frontiers in Aging Neuroscience, 2019, vol. 6, p. 11-236
https://doi.org/10.3389/fnagi.2019.00236
dc.rights.none.fl_str_mv cc-by (c) Folch, Jaume et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Folch, Jaume et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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