Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors

(1) OBJECTIVE: To assess the performance of CA125, HE4, ROMA index and CPH-I index to preoperatively identify epithelial ovarian cancer (EOC) or metastatic cancer in the ovary (MCO). (2) METHODS: single center retrospective study, including women with a diagnosis of adnexal mass. We obtained the AUC...

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Autores: Carreras Dieguez, Núria, Glickman, Ariel, Munmany, Meritxell, Casanovas, Georgina, Agustí, Núria, Díaz Feijoo, Berta, Saco, Adela, Sánchez Hoyo, Beatriz, Gaba, Lydia, Rovirosa Casino, Angeles, Pahisa Fábregas, Jaume, Fernández Galán, Esther, Torné Bladé, Aureli, Fusté, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/187391
Acceso en línea:https://hdl.handle.net/2445/187391
Access Level:acceso abierto
Palabra clave:Marcadors tumorals
Càncer d'ovari
Metàstasi
Tumor markers
Ovarian cancer
Metastasis
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spelling Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal TumorsCarreras Dieguez, Núria Glickman, ArielMunmany, MeritxellCasanovas, GeorginaAgustí, NúriaDíaz Feijoo, BertaSaco, AdelaSánchez Hoyo, BeatrizGaba, LydiaRovirosa Casino, AngelesPahisa Fábregas, JaumeFernández Galán, EstherTorné Bladé, AureliFusté, PereMarcadors tumoralsCàncer d'ovariMetàstasiTumor markersOvarian cancerMetastasis(1) OBJECTIVE: To assess the performance of CA125, HE4, ROMA index and CPH-I index to preoperatively identify epithelial ovarian cancer (EOC) or metastatic cancer in the ovary (MCO). (2) METHODS: single center retrospective study, including women with a diagnosis of adnexal mass. We obtained the AUC, sensitivity, specificity and predictive values were of HE4, CA125, ROMA and CPH-I for the diagnosis of EOC and MCO. Subgroup analysis for women harboring adnexal masses with inconclusive diagnosis of malignancy by ultrasound features and Stage I EOC was performed. (3) RESULTS: 1071 patients were included, 852 (79.6%) presented benign/borderline tumors and 219 (20.4%) presented EOC/MCO. AUC for HE4 was higher than for CA125 (0.91 vs. 0.87). No differences were seen between AUC of ROMA and CPH-I, but they were both higher than HE4 AUC. None of the tumor markers alone achieved a sensitivity of 90%; HE4 was highly specific (93.5%). ROMA showed a sensitivity and specificity of 91.1% and 84.6% respectively, while CPH-I showed a sensitivity of 91.1% with 79.2% specificity. For patients with inconclusive diagnosis of malignancy by ultrasound features and with Stage I EOC, ROMA showed the best diagnostic performance (4) CONCLUSIONS: ROMA and CPH-I perform better than tumor markers alone to identify patients harboring EOC or MCO. They can be helpful to assess the risk of malignancy of adnexal masses, especially in cases where ultrasonographic diagnosis is challenging (stage I EOC, inconclusive diagnosis of malignancy by ultrasound features).MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/187391Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/diagnostics12010226Diagnostics, 2022, vol. 12, num. 1, p. 226https://doi.org/10.3390/diagnostics12010226cc-by (c) Carreras, Núria et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1873912026-05-27T06:46:51Z
dc.title.none.fl_str_mv Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
title Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
spellingShingle Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
Carreras Dieguez, Núria
Marcadors tumorals
Càncer d'ovari
Metàstasi
Tumor markers
Ovarian cancer
Metastasis
title_short Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
title_full Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
title_fullStr Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
title_full_unstemmed Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
title_sort Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors
dc.creator.none.fl_str_mv Carreras Dieguez, Núria
Glickman, Ariel
Munmany, Meritxell
Casanovas, Georgina
Agustí, Núria
Díaz Feijoo, Berta
Saco, Adela
Sánchez Hoyo, Beatriz
Gaba, Lydia
Rovirosa Casino, Angeles
Pahisa Fábregas, Jaume
Fernández Galán, Esther
Torné Bladé, Aureli
Fusté, Pere
author Carreras Dieguez, Núria
author_facet Carreras Dieguez, Núria
Glickman, Ariel
Munmany, Meritxell
Casanovas, Georgina
Agustí, Núria
Díaz Feijoo, Berta
Saco, Adela
Sánchez Hoyo, Beatriz
Gaba, Lydia
Rovirosa Casino, Angeles
Pahisa Fábregas, Jaume
Fernández Galán, Esther
Torné Bladé, Aureli
Fusté, Pere
author_role author
author2 Glickman, Ariel
Munmany, Meritxell
Casanovas, Georgina
Agustí, Núria
Díaz Feijoo, Berta
Saco, Adela
Sánchez Hoyo, Beatriz
Gaba, Lydia
Rovirosa Casino, Angeles
Pahisa Fábregas, Jaume
Fernández Galán, Esther
Torné Bladé, Aureli
Fusté, Pere
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors tumorals
Càncer d'ovari
Metàstasi
Tumor markers
Ovarian cancer
Metastasis
topic Marcadors tumorals
Càncer d'ovari
Metàstasi
Tumor markers
Ovarian cancer
Metastasis
description (1) OBJECTIVE: To assess the performance of CA125, HE4, ROMA index and CPH-I index to preoperatively identify epithelial ovarian cancer (EOC) or metastatic cancer in the ovary (MCO). (2) METHODS: single center retrospective study, including women with a diagnosis of adnexal mass. We obtained the AUC, sensitivity, specificity and predictive values were of HE4, CA125, ROMA and CPH-I for the diagnosis of EOC and MCO. Subgroup analysis for women harboring adnexal masses with inconclusive diagnosis of malignancy by ultrasound features and Stage I EOC was performed. (3) RESULTS: 1071 patients were included, 852 (79.6%) presented benign/borderline tumors and 219 (20.4%) presented EOC/MCO. AUC for HE4 was higher than for CA125 (0.91 vs. 0.87). No differences were seen between AUC of ROMA and CPH-I, but they were both higher than HE4 AUC. None of the tumor markers alone achieved a sensitivity of 90%; HE4 was highly specific (93.5%). ROMA showed a sensitivity and specificity of 91.1% and 84.6% respectively, while CPH-I showed a sensitivity of 91.1% with 79.2% specificity. For patients with inconclusive diagnosis of malignancy by ultrasound features and with Stage I EOC, ROMA showed the best diagnostic performance (4) CONCLUSIONS: ROMA and CPH-I perform better than tumor markers alone to identify patients harboring EOC or MCO. They can be helpful to assess the risk of malignancy of adnexal masses, especially in cases where ultrasonographic diagnosis is challenging (stage I EOC, inconclusive diagnosis of malignancy by ultrasound features).
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/187391
url https://hdl.handle.net/2445/187391
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/diagnostics12010226
Diagnostics, 2022, vol. 12, num. 1, p. 226
https://doi.org/10.3390/diagnostics12010226
dc.rights.none.fl_str_mv cc-by (c) Carreras, Núria et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Carreras, Núria et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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