Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue

In this work we describe a potential role for GRK2 in myeloid cells in orchestrating the responses that promote both inflammation and excessive ROS production by NADPH oxidase in PVAT to decrease endothelium-dependent vasodilation.

Detalles Bibliográficos
Autores: González-Amor, María, Vila-Bedmar, Rocio, Rodrigues-Díez, Raquel, Moreno-Carriles, Rosa, C. Arcones, Alba, Cruces-Sande, Marta, Salaices, Mercedes, Mayor Jr, Federico, Briones, Ana M., Murga, Cristina
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Rey Juan Carlos
Repositorio:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
OAI Identifier:oai:burjcdigital.urjc.es:10115/27716
Acceso en línea:https://hdl.handle.net/10115/27716
Access Level:acceso abierto
Palabra clave:perivascular adipose tissue (PVAT)
G protein-coupled receptor kinase 2 (GRK2)
tumor necrosis factor-α (TNFα)
NADPH oxidase (Nox)
endothelial dysfunction
Descripción
Sumario:In this work we describe a potential role for GRK2 in myeloid cells in orchestrating the responses that promote both inflammation and excessive ROS production by NADPH oxidase in PVAT to decrease endothelium-dependent vasodilation.

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