Ruthenium metallodendrimer against triple-negative breast cancer in mice

Carbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model with triple-negative breast cancer. The dendrimer entered into the cells efficiently, and exhibited selective toxici...

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Detalhes bibliográficos
Autores: Michlewska, Sylwia, Wójkowska, Dagmara, Watala, Cezary, Skiba, Elzbieta, Ortega Lopez, Paula|||0000-0003-0377-5429, Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935, Bryszewska, Maria, Ionov, Maksim
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/57875
Acesso em linha:http://hdl.handle.net/10017/57875
https://dx.doi.org/10.1016/j.nano.2023.102703
Access Level:acceso abierto
Palavra-chave:Ruthenium metallodendrimer
Anticancer agent
Toxicity
Tumour weight
In vivo
Química
Chemistry
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spelling Ruthenium metallodendrimer against triple-negative breast cancer in miceMichlewska, SylwiaWójkowska, DagmaraWatala, CezarySkiba, ElzbietaOrtega Lopez, Paula|||0000-0003-0377-5429Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935Bryszewska, MariaIonov, MaksimRuthenium metallodendrimerAnticancer agentToxicityTumour weightIn vivoQuímicaChemistryCarbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model with triple-negative breast cancer. The dendrimer entered into the cells efficiently, and exhibited selective toxicity for 4T1 cells. In vivo investigations proved that a local injection of CRD13 caused a reduction of tumour mass and was non-toxic. ICP analyses indicated that Ru(II) accumulated in all tested tissues with a greater content detected in the tumour.European CommissionMinisterio de Economía y CompetitividadComunidad de MadridJunta de Comunidades de Castilla-La Mancha20232023-08-15journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/57875https://dx.doi.org/10.1016/j.nano.2023.102703reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available Not availableComunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available Not availableComunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available Not availableJunta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 SBPLY%2F17%2F180501%2F000358 ESEC 2018%2F31%2FF%2FNZ5%2F03454 EUopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/578752026-06-18T11:13:07Z
dc.title.none.fl_str_mv Ruthenium metallodendrimer against triple-negative breast cancer in mice
title Ruthenium metallodendrimer against triple-negative breast cancer in mice
spellingShingle Ruthenium metallodendrimer against triple-negative breast cancer in mice
Michlewska, Sylwia
Ruthenium metallodendrimer
Anticancer agent
Toxicity
Tumour weight
In vivo
Química
Chemistry
title_short Ruthenium metallodendrimer against triple-negative breast cancer in mice
title_full Ruthenium metallodendrimer against triple-negative breast cancer in mice
title_fullStr Ruthenium metallodendrimer against triple-negative breast cancer in mice
title_full_unstemmed Ruthenium metallodendrimer against triple-negative breast cancer in mice
title_sort Ruthenium metallodendrimer against triple-negative breast cancer in mice
dc.creator.none.fl_str_mv Michlewska, Sylwia
Wójkowska, Dagmara
Watala, Cezary
Skiba, Elzbieta
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Bryszewska, Maria
Ionov, Maksim
author Michlewska, Sylwia
author_facet Michlewska, Sylwia
Wójkowska, Dagmara
Watala, Cezary
Skiba, Elzbieta
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Bryszewska, Maria
Ionov, Maksim
author_role author
author2 Wójkowska, Dagmara
Watala, Cezary
Skiba, Elzbieta
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Bryszewska, Maria
Ionov, Maksim
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ruthenium metallodendrimer
Anticancer agent
Toxicity
Tumour weight
In vivo
Química
Chemistry
topic Ruthenium metallodendrimer
Anticancer agent
Toxicity
Tumour weight
In vivo
Química
Chemistry
description Carbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model with triple-negative breast cancer. The dendrimer entered into the cells efficiently, and exhibited selective toxicity for 4T1 cells. In vivo investigations proved that a local injection of CRD13 caused a reduction of tumour mass and was non-toxic. ICP analyses indicated that Ru(II) accumulated in all tested tissues with a greater content detected in the tumour.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-08-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/57875
https://dx.doi.org/10.1016/j.nano.2023.102703
url http://hdl.handle.net/10017/57875
https://dx.doi.org/10.1016/j.nano.2023.102703
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available Not available
Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available Not available
Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available Not available
Junta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 SBPLY%2F17%2F180501%2F000358 ES
EC 2018%2F31%2FF%2FNZ5%2F03454 EU
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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