Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture

Aneurisme intracranial; Estatines; Aspirina

Detalles Bibliográficos
Autores: Terceño, Mikel, Remollo Friedemann, Sebastian, Silva, Yolanda, Werner, Mariano, Vera Monge, Víctor Augusto, Serena, Joaquín, Castaño Duque, Carlos, Bashir Viturro, Saima
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/11184
Acceso en línea:https://hdl.handle.net/11351/11184
Access Level:acceso abierto
Palabra clave:Aneurismes cerebrals - Prevenció
Estatines (Medicaments cardiovasculars)
Aspirina
CHEMICALS AND DRUGS::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Hydroxybenzoates::Salicylates::Aspirin
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents::Anticholesteremic Agents::Hydroxymethylglutaryl-CoA Reductase Inhibitors
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Intracranial Aneurysm
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::aneurisma intracraneal
COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::hidrocarburos::hidrocarburos cíclicos::hidrocarburos aromáticos::derivados del benceno::fenoles::hidroxibenzoatos::salicilatos::aspirina
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::antimetabolitos::hipolipemiantes::anticolesterolemiantes::inhibidores de las hidroximetilglutaril-CoA reductasas
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
title Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
spellingShingle Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
Terceño, Mikel
Aneurismes cerebrals - Prevenció
Estatines (Medicaments cardiovasculars)
Aspirina
CHEMICALS AND DRUGS::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Hydroxybenzoates::Salicylates::Aspirin
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents::Anticholesteremic Agents::Hydroxymethylglutaryl-CoA Reductase Inhibitors
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Intracranial Aneurysm
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::aneurisma intracraneal
COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::hidrocarburos::hidrocarburos cíclicos::hidrocarburos aromáticos::derivados del benceno::fenoles::hidroxibenzoatos::salicilatos::aspirina
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::antimetabolitos::hipolipemiantes::anticolesterolemiantes::inhibidores de las hidroximetilglutaril-CoA reductasas
title_short Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
title_full Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
title_fullStr Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
title_full_unstemmed Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
title_sort Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
dc.creator.none.fl_str_mv Terceño, Mikel
Remollo Friedemann, Sebastian
Silva, Yolanda
Werner, Mariano
Vera Monge, Víctor Augusto
Serena, Joaquín
Castaño Duque, Carlos
Bashir Viturro, Saima
author Terceño, Mikel
author_facet Terceño, Mikel
Remollo Friedemann, Sebastian
Silva, Yolanda
Werner, Mariano
Vera Monge, Víctor Augusto
Serena, Joaquín
Castaño Duque, Carlos
Bashir Viturro, Saima
author_role author
author2 Remollo Friedemann, Sebastian
Silva, Yolanda
Werner, Mariano
Vera Monge, Víctor Augusto
Serena, Joaquín
Castaño Duque, Carlos
Bashir Viturro, Saima
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Terceño M] Stroke Unit, Department of Neurology Girona Biomedical Research Institute (IDIBGI). Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. Interventional Neuroradiology Unit, Department of Neurosciences, Germans Trias i Pujol University Hospital, Badalona, Spain. [Remollo S, Werner M] Interventional Neuroradiology Unit, Department of Neurosciences, Germans Trias i Pujol University Hospital, Badalona, Spain. [Silva Y, Bashir S, Vera-Monge VA, Serena J, Castaño C] Stroke Unit, Department of Neurology Girona Biomedical Research Institute (IDIBGI). Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain
Hospital Universitari de Girona Dr Josep Trueta
dc.subject.none.fl_str_mv Aneurismes cerebrals - Prevenció
Estatines (Medicaments cardiovasculars)
Aspirina
CHEMICALS AND DRUGS::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Hydroxybenzoates::Salicylates::Aspirin
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents::Anticholesteremic Agents::Hydroxymethylglutaryl-CoA Reductase Inhibitors
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Intracranial Aneurysm
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::aneurisma intracraneal
COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::hidrocarburos::hidrocarburos cíclicos::hidrocarburos aromáticos::derivados del benceno::fenoles::hidroxibenzoatos::salicilatos::aspirina
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::antimetabolitos::hipolipemiantes::anticolesterolemiantes::inhibidores de las hidroximetilglutaril-CoA reductasas
topic Aneurismes cerebrals - Prevenció
Estatines (Medicaments cardiovasculars)
Aspirina
CHEMICALS AND DRUGS::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Hydroxybenzoates::Salicylates::Aspirin
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents::Anticholesteremic Agents::Hydroxymethylglutaryl-CoA Reductase Inhibitors
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Intracranial Aneurysm
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::aneurisma intracraneal
COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::hidrocarburos::hidrocarburos cíclicos::hidrocarburos aromáticos::derivados del benceno::fenoles::hidroxibenzoatos::salicilatos::aspirina
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::antimetabolitos::hipolipemiantes::anticolesterolemiantes::inhibidores de las hidroximetilglutaril-CoA reductasas
description Aneurisme intracranial; Estatines; Aspirina
publishDate 2021
dc.date.none.fl_str_mv 2021
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/11184
url https://hdl.handle.net/11351/11184
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PloS One;16(2)
https://doi.org/10.1371/journal.pone.0247153
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm ruptureTerceño, MikelRemollo Friedemann, SebastianSilva, YolandaWerner, MarianoVera Monge, Víctor AugustoSerena, JoaquínCastaño Duque, CarlosBashir Viturro, SaimaAneurismes cerebrals - PrevencióEstatines (Medicaments cardiovasculars)AspirinaCHEMICALS AND DRUGS::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Hydroxybenzoates::Salicylates::AspirinCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents::Anticholesteremic Agents::Hydroxymethylglutaryl-CoA Reductase InhibitorsDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Intracranial AneurysmENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::aneurisma intracranealCOMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::hidrocarburos::hidrocarburos cíclicos::hidrocarburos aromáticos::derivados del benceno::fenoles::hidroxibenzoatos::salicilatos::aspirinaCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::antimetabolitos::hipolipemiantes::anticolesterolemiantes::inhibidores de las hidroximetilglutaril-CoA reductasasAneurisme intracranial; Estatines; AspirinaAneurismo intracraneal; Estatinas; AspirinaIntracranial aneurysm; Statins; AspirinBackground: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture. We aim to determine the effect of this drugs on the risk of rupture of IA. Patients and methods: We performed a retrospective cohort study from a prospective database of patients with IA treated in our institution between January 2013 and December 2018. Demographics, previous oral treatments, presence of multiple aneurysms, size of aneurysm, lobulation, location and morphology of the aneurysms were recorded. Patients were dichotomized as ruptured and unruptured IA. Results: A total of 408 IA were treated, of which 283 (68.6%) were in women. The median age was 53, 194 (47.5%) were ruptured IA. 38 patients (9.3%) were receiving ASA and 84 (20.6%) were receiving statins at the moment of the IA diagnosis. In the multivariable regression analysis, ASA plus statin use and multiple aneurysms were independently associated with unruptured IA (OR 5.01, 95% CI, 1.37-18.33, P = 0.015 and OR 2.72, 95% CI 1.68-4.27, P<0.001, respectively). Whereas, lobulated wall aneurysm and PComA/AComA location were inversely and independently associated with unruptured IA condition (OR 0.34, 95% CI 0.21-0.55, P<0.001 and OR 0.37, 95% CI 0.23-0.60, P<0.001, respectively). However, ASA and statins in monotherapy were not independently associated with unruptured IA condition. Conclusions: In our study population ASA plus statins treatment is independently associated with unruptured IA. Larger and prospective studies are required to explore this potential protective effect against IA rupture.Public Library of ScienceInstitut Català de la Salut[Terceño M] Stroke Unit, Department of Neurology Girona Biomedical Research Institute (IDIBGI). Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. Interventional Neuroradiology Unit, Department of Neurosciences, Germans Trias i Pujol University Hospital, Badalona, Spain. [Remollo S, Werner M] Interventional Neuroradiology Unit, Department of Neurosciences, Germans Trias i Pujol University Hospital, Badalona, Spain. [Silva Y, Bashir S, Vera-Monge VA, Serena J, Castaño C] Stroke Unit, Department of Neurology Girona Biomedical Research Institute (IDIBGI). Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, SpainHospital Universitari de Girona Dr Josep Trueta202420242021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttps://hdl.handle.net/11351/11184Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésPloS One;16(2)https://doi.org/10.1371/journal.pone.0247153Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/111842026-06-12T09:38:37Z
score 15.812429

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