Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome

The goal of this study was to evaluate the influence of obstructive sleep apnoea on the severity and short-term prognosis of patients admitted for acute coronary syndrome. Obstructive sleep apnoea was defined as an apnoea–hypopnoea index (AHI) >15 h−1. We evaluated the acute coronary syndrome sev...

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Autores: Barbé Illa, Ferran, Sánchez de la Torre, Alicia, Abad, Jorge, Durán-Cantolla, Joaquín, Mediano, Olga, Amilibia, Jose, Masdeu, María José, Florés, Marina, Barceló Bennasar, Antònia, Peña, Mónica de la, Aldomá, Albina, Worner, Fernando, Valls Marsal, Joan, Castellà, Gerard, Sánchez de la Torre, Manuel
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2015
País:España
Recursos:Universitat de Lleida (UdL)
Repositório:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/63120
Acesso em linha:https://doi.org/10.1183/09031936.00071714
http://hdl.handle.net/10459.1/63120
Access Level:Acceso aberto
Palavra-chave:Obstructive sleep apnoea
Acute coronary syndrome
OSA
ACS
Cardiovascular disease
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spelling Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndromeBarbé Illa, FerranSánchez de la Torre, AliciaAbad, JorgeDurán-Cantolla, JoaquínMediano, OlgaAmilibia, JoseMasdeu, María JoséFlorés, MarinaBarceló Bennasar, AntòniaPeña, Mónica de laAldomá, AlbinaWorner, FernandoValls Marsal, JoanCastellà, GerardSánchez de la Torre, ManuelObstructive sleep apnoeaAcute coronary syndromeOSAACSCardiovascular diseaseThe goal of this study was to evaluate the influence of obstructive sleep apnoea on the severity and short-term prognosis of patients admitted for acute coronary syndrome. Obstructive sleep apnoea was defined as an apnoea–hypopnoea index (AHI) >15 h−1. We evaluated the acute coronary syndrome severity (ejection fraction, Killip class, number of diseased vessels, and plasma peak troponin) and short-term prognosis (length of hospitalisation, complications and mortality). We included 213 patients with obstructive sleep apnoea (mean±SD AHI 30±14 h−1, 61±10 years, 80% males) and 218 controls (AHI 6±4 h−1, 57±12 years, 82% males). Patients with obstructive sleep apnoea exhibited a higher prevalence of systemic hypertension (55% versus 37%, p<0.001), higher body mass index (29±4 kg·m−2 versus 26±4 kg·m−2, p<0.001), and lower percentage of smokers (61% versus 71%, p=0.04). After adjusting for smoking, age, body mass index and hypertension, the plasma peak troponin levels were significantly elevated in the obstructive sleep apnoea group (831±908 ng·L−1 versus 987±884 ng·L−1, p=0.03) and higher AHI severity was associated with an increased number of diseased vessels ( p=0.04). The mean length of stay in the coronary care unit was higher in the obstructive sleep apnoea group ( p=0.03). This study indicates that obstructive sleep apnoea is related to an increase in the peak plasma troponin levels, number of diseased vessels, and length of stay in the coronary care unit.Support statement: Supported by ResMed Ltd. (Australia), Fondo de Investigación Sanitaria (PI10/02763 and PI10/ 02745), the Spanish Respiratory Society (SEPAR), the Catalonian Cardiology Society, Esteve-Teijin (Spain), Oxigen Salud (Spain), ALLER and Neumomadrid.European Respiratory Society2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://doi.org/10.1183/09031936.00071714http://hdl.handle.net/10459.1/63120reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésVersió postprint del document publicat a https://doi.org/10.1183/09031936.00071714European Respiratory Journal, 2015, vol. 45, p. 419-427© ERS, 2015info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/631202026-06-24T12:42:17Z
dc.title.none.fl_str_mv Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome
title Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome
spellingShingle Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome
Barbé Illa, Ferran
Obstructive sleep apnoea
Acute coronary syndrome
OSA
ACS
Cardiovascular disease
title_short Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome
title_full Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome
title_fullStr Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome
title_full_unstemmed Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome
title_sort Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome
dc.creator.none.fl_str_mv Barbé Illa, Ferran
Sánchez de la Torre, Alicia
Abad, Jorge
Durán-Cantolla, Joaquín
Mediano, Olga
Amilibia, Jose
Masdeu, María José
Florés, Marina
Barceló Bennasar, Antònia
Peña, Mónica de la
Aldomá, Albina
Worner, Fernando
Valls Marsal, Joan
Castellà, Gerard
Sánchez de la Torre, Manuel
author Barbé Illa, Ferran
author_facet Barbé Illa, Ferran
Sánchez de la Torre, Alicia
Abad, Jorge
Durán-Cantolla, Joaquín
Mediano, Olga
Amilibia, Jose
Masdeu, María José
Florés, Marina
Barceló Bennasar, Antònia
Peña, Mónica de la
Aldomá, Albina
Worner, Fernando
Valls Marsal, Joan
Castellà, Gerard
Sánchez de la Torre, Manuel
author_role author
author2 Sánchez de la Torre, Alicia
Abad, Jorge
Durán-Cantolla, Joaquín
Mediano, Olga
Amilibia, Jose
Masdeu, María José
Florés, Marina
Barceló Bennasar, Antònia
Peña, Mónica de la
Aldomá, Albina
Worner, Fernando
Valls Marsal, Joan
Castellà, Gerard
Sánchez de la Torre, Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obstructive sleep apnoea
Acute coronary syndrome
OSA
ACS
Cardiovascular disease
topic Obstructive sleep apnoea
Acute coronary syndrome
OSA
ACS
Cardiovascular disease
description The goal of this study was to evaluate the influence of obstructive sleep apnoea on the severity and short-term prognosis of patients admitted for acute coronary syndrome. Obstructive sleep apnoea was defined as an apnoea–hypopnoea index (AHI) >15 h−1. We evaluated the acute coronary syndrome severity (ejection fraction, Killip class, number of diseased vessels, and plasma peak troponin) and short-term prognosis (length of hospitalisation, complications and mortality). We included 213 patients with obstructive sleep apnoea (mean±SD AHI 30±14 h−1, 61±10 years, 80% males) and 218 controls (AHI 6±4 h−1, 57±12 years, 82% males). Patients with obstructive sleep apnoea exhibited a higher prevalence of systemic hypertension (55% versus 37%, p<0.001), higher body mass index (29±4 kg·m−2 versus 26±4 kg·m−2, p<0.001), and lower percentage of smokers (61% versus 71%, p=0.04). After adjusting for smoking, age, body mass index and hypertension, the plasma peak troponin levels were significantly elevated in the obstructive sleep apnoea group (831±908 ng·L−1 versus 987±884 ng·L−1, p=0.03) and higher AHI severity was associated with an increased number of diseased vessels ( p=0.04). The mean length of stay in the coronary care unit was higher in the obstructive sleep apnoea group ( p=0.03). This study indicates that obstructive sleep apnoea is related to an increase in the peak plasma troponin levels, number of diseased vessels, and length of stay in the coronary care unit.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1183/09031936.00071714
http://hdl.handle.net/10459.1/63120
url https://doi.org/10.1183/09031936.00071714
http://hdl.handle.net/10459.1/63120
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a https://doi.org/10.1183/09031936.00071714
European Respiratory Journal, 2015, vol. 45, p. 419-427
dc.rights.none.fl_str_mv © ERS, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © ERS, 2015
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv European Respiratory Society
publisher.none.fl_str_mv European Respiratory Society
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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