Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain

Acute exacerbation; Fibrosing interstitial lung disease; Survival

Detalles Bibliográficos
Autores: Ferreiro Posse, Antia, Granados Rosales, Galo David, Salvador-Fernàndez, Sara, Pilia, María Florencia, Espejo Castellanos, David, Romero Mesones, Christian Eduardo, Ojanguren, Iñigo, Muñoz, Xavier, Villar, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/13057
Acceso en línea:http://hdl.handle.net/11351/13057
Access Level:acceso abierto
Palabra clave:Fibrosi pulmonar - Prognosi
Pulmons - Malalties - Prognosi
Marcadors bioquímics
DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression
DISEASES::Respiratory Tract Diseases::Lung Diseases::Pulmonary Fibrosis
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::fibrosis pulmonar
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/13057
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain
title Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain
spellingShingle Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain
Ferreiro Posse, Antia
Fibrosi pulmonar - Prognosi
Pulmons - Malalties - Prognosi
Marcadors bioquímics
DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression
DISEASES::Respiratory Tract Diseases::Lung Diseases::Pulmonary Fibrosis
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::fibrosis pulmonar
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
title_short Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain
title_full Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain
title_fullStr Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain
title_full_unstemmed Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain
title_sort Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in Spain
dc.creator.none.fl_str_mv Ferreiro Posse, Antia
Granados Rosales, Galo David
Salvador-Fernàndez, Sara
Pilia, María Florencia
Espejo Castellanos, David
Romero Mesones, Christian Eduardo
Ojanguren, Iñigo
Muñoz, Xavier
Villar, Ana
author Ferreiro Posse, Antia
author_facet Ferreiro Posse, Antia
Granados Rosales, Galo David
Salvador-Fernàndez, Sara
Pilia, María Florencia
Espejo Castellanos, David
Romero Mesones, Christian Eduardo
Ojanguren, Iñigo
Muñoz, Xavier
Villar, Ana
author_role author
author2 Granados Rosales, Galo David
Salvador-Fernàndez, Sara
Pilia, María Florencia
Espejo Castellanos, David
Romero Mesones, Christian Eduardo
Ojanguren, Iñigo
Muñoz, Xavier
Villar, Ana
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Ferreiro-Posse A] Department of Respiratory Medicine, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain. [Granados G, Espejo D, Romero C, Ojanguren I, Muñoz X, Villar A] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Spanish Biomedical Research Networking Centre (CIBERES), Carlos III Health Research Institute, Madrid, Spain. [Salvador S] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Pilia MF] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Fibrosi pulmonar - Prognosi
Pulmons - Malalties - Prognosi
Marcadors bioquímics
DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression
DISEASES::Respiratory Tract Diseases::Lung Diseases::Pulmonary Fibrosis
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::fibrosis pulmonar
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
topic Fibrosi pulmonar - Prognosi
Pulmons - Malalties - Prognosi
Marcadors bioquímics
DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression
DISEASES::Respiratory Tract Diseases::Lung Diseases::Pulmonary Fibrosis
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::fibrosis pulmonar
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
description Acute exacerbation; Fibrosing interstitial lung disease; Survival
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11351/13057
url http://hdl.handle.net/11351/13057
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine;14(6)
https://doi.org/10.3390/jcm14061974
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403058750881792
spelling Retrospective Analysis of Predictive Biomarkers of Survival in Acute Exacerbation of Fibrosing Interstitial Lung Disease: A Single-Center Study in SpainFerreiro Posse, AntiaGranados Rosales, Galo David Salvador-Fernàndez, SaraPilia, María FlorenciaEspejo Castellanos, DavidRomero Mesones, Christian EduardoOjanguren, IñigoMuñoz, XavierVillar, AnaFibrosi pulmonar - PrognosiPulmons - Malalties - PrognosiMarcadors bioquímicsDISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, InterstitialDISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease ProgressionDISEASES::Respiratory Tract Diseases::Lung Diseases::Pulmonary FibrosisCHEMICALS AND DRUGS::Biological Factors::BiomarkersENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticialesENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedadENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::fibrosis pulmonarCOMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadoresAcute exacerbation; Fibrosing interstitial lung disease; SurvivalExacerbació aguda; Malaltia pulmonar intersticial fibrosant; SupervivènciaExacerbación aguda; Enfermedad pulmonar intersticial fibrosante; SupervivenciaBackground: Fibrosing interstitial lung diseases can evolve into acute exacerbations, which significantly impact morbidity and mortality. Currently, no routinely used clinical biomarkers can discern the potential progression in these patients. This study aims to analyze different biological markers used in routine clinical practice as possible predictive biomarkers for patients with acute fibrosing interstitial lung disease exacerbation. Methods: We conducted a retrospective, single-center study including patients diagnosed with acute exacerbation of fibrosing interstitial lung disease who required hospitalization between 2018 and 2019 at Vall d'Hebron Hospital, Spain. Patient demographics, clinical data, respiratory function, and comorbidities were collected at baseline. The primary outcome was survival at 30 days, 90 days, and 365 days, using Kaplan-Meier survival analysis and Cox regression. Results: Twenty-nine patients were included (mean age 70.4 years). At the 3-month follow-up, patients with ischemic heart disease showed higher survival rates (p = 0.02). Identifying an infection as the etiology of the exacerbation was associated with worse one-year survival rates compared to idiopathic cases (p = 0.03). Elevated levels of leukocytes (p < 0.01), neutrophils (p < 0.01), and fibrinogen (p = 0.03) were predictors of mortality. Additionally, patients who received a cumulative dose of corticosteroids between 501 and 1000 mg during the exacerbation showed higher one-year survival (p < 0.01). Conclusions: Routine clinical markers can help predict outcomes in AE-f-ILD. Further multicenter studies should validate these findings and assess the role of therapies in its management.MDPIInstitut Català de la Salut[Ferreiro-Posse A] Department of Respiratory Medicine, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain. [Granados G, Espejo D, Romero C, Ojanguren I, Muñoz X, Villar A] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Spanish Biomedical Research Networking Centre (CIBERES), Carlos III Health Research Institute, Madrid, Spain. [Salvador S] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Pilia MF] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13057Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésJournal of Clinical Medicine;14(6)https://doi.org/10.3390/jcm14061974Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/130572026-06-12T09:38:37Z
score 15,811543

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