Multi-Biomarker Profiling and Recurrent Hospitalizations in Heart Failure

Despite advances in pharmacologic therapy and devices, patients with heart failure (HF) continue to have significant rehospitalization rates and risk prediction remains challenging. We sought to explore the value of a multi-biomarker panel [including NT-proBNP, high-sensitivity cardiac troponin T (h...

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Detalles Bibliográficos
Autores: Bayés-Genís, Antoni|||0000-0002-3044-197X, Núñez, Julio|||0000-0003-1672-7119, Núñez, Eduardo, Martínez, Jaume Barallat, Pastor Ferrer, Maria-Cruz, de Antonio Ferrer, Marta|||0000-0002-4319-797X, Zamora, Elisabet|||0000-0001-5317-7481, Sanchis, Juan|||0000-0003-0797-8709, Rosés, Josep Lupón
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186011
Acceso en línea:https://ddd.uab.cat/record/186011
https://dx.doi.org/urn:doi:10.3389/fcvm.2016.00037
Access Level:acceso abierto
Palabra clave:Biomarkers
Heart failure
Hospitalizations
Prediction
NT-proBNP
Hs-tnt
ST2
Descripción
Sumario:Despite advances in pharmacologic therapy and devices, patients with heart failure (HF) continue to have significant rehospitalization rates and risk prediction remains challenging. We sought to explore the value of a multi-biomarker panel [including NT-proBNP, high-sensitivity cardiac troponin T (hs-TnT), and ST2] on top of clinical assessment for long-term prediction of recurrent hospitalizations in HF. NT-proBNP, hs-TnT, and ST2 (suppression of tumorigenicity-2) levels were measured in 891 consecutive ambulatory HF patients. The independent association between the multi-biomarker panel and recurrent hospitalizations was assessed through a multivariable negative binomial regression and expressed as incidence rates ratios. McFadden pseudo- R 2 and goodness-of-fit measures were also used. The total number of unplanned hospitalizations [all-cause, cardiovascular (CV)-, and HF-related] were selected as the primary endpoints. At a mean follow-up of 4.2 ± 2.1 years, 1623 all-cause hospitalizations in 498 patients (55.9%), 710 CV-related hospitalizations in 331 patients (37.2%), and 444 HF-related hospitalizations in 214 patients (24.1%) were registered. The crude incidence of all-cause, CV-, and HF-related recurrent hospitalizations was significantly higher for patients with the multi-biomarker panel above the cut-point (hs-TnT.

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