Multiplexed monitoring of a novel autoantibody diagnostic signature of colorectal cancer using HaloTag technology-based electrochemical immunosensing platform

[Background and Purpose]: The humoral immune response in cancer patients can be used for early detection of the disease. Autoantibodies raised against tumor-associated antigens (TAAs) are promising clinical biomarkers for reliable cancer diagnosis, prognosis, and therapy monitoring. In this study, a...

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Detalles Bibliográficos
Autores: Garranzo Asensio, María, Guzmán-Aránguez, Ana I., Povedano, Eloy, Ruiz-Valdepeñas Montiel, Víctor, Povés, Carmen, Fernandez-Aceñero, M. Jesús, Montero-Calle, Ana, Solís-Fernández, Guillermo, Fernández-Díez, Servando, Camps, Jordi, Arenas, Meritxell, Rodríguez-Tomàs, Elisabeth, Joven, Jorge, Sánchez-Martínez, María Cruz, Rodríguez, Nuria, Domínguez, Gemma, Yáñez-Sedeño, Paloma, Pingarrón, José Manuel, Campuzano, Susana, Barderas, Rodrigo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/222297
Acceso en línea:http://hdl.handle.net/10261/222297
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Biosensors
Early cancer detection
Electrochemical bioplatforms
Halotag fusion proteins
Liquid biopsy
Descripción
Sumario:[Background and Purpose]: The humoral immune response in cancer patients can be used for early detection of the disease. Autoantibodies raised against tumor-associated antigens (TAAs) are promising clinical biomarkers for reliable cancer diagnosis, prognosis, and therapy monitoring. In this study, an electrochemical disposable multiplexed immunosensing platform able to integrate difficult- and easy-to-express colorectal cancer (CRC) TAAs is reported for the sensitive determination of eight CRC-specific autoantibodies.

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