Predictive Computational Modeling of the Complement System in Health and Disease for Complement Therapeutics Development (Cmodel)
The complement system represents a highly complex network of proteins that plays acritical role in the immune system and is associated with various pathologies, some ofwhich with high impact in patients’ quality of life. Mathematical computational models enable the representation of complex biologic...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/119152 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/119152 |
| Access Level: | acceso abierto |
| Palabra clave: | 519.87(043.2) Farmacia 3209 Farmacología |
| Sumario: | The complement system represents a highly complex network of proteins that plays acritical role in the immune system and is associated with various pathologies, some ofwhich with high impact in patients’ quality of life. Mathematical computational models enable the representation of complex biological systems, promoting their investigation and providing valuable insights and hypotheses for further experimental exploration. Objectives. The primary objective of this study is to develop and validate computational mathematical models based on the network of interactions within the complement system, aiming to assess their performance and potential utility in unravelling disease mechanisms, facilitating the development of innovative therapies and patient management in clinical practice... |
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