The Potential Use of Antibiotics Against Helicobacter pylori Infection: Biopharmaceutical Implications

[EN] Helicobacter pylori (H. pylori) is a notorious, recalcitrant and silent germ, which can cause a variety of debilitating stomach diseases, including gastric and duodenal ulcers and gastric cancer. This microbe predominantly colonizes the mucosal layer of the human stomach and survives in the inh...

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Detalles Bibliográficos
Autores: Miri, Amir Hossein, Kamankesh, Mojtaba, Liu, Chenguang, Wacker, Matthias G., Haririan, Ismaeil, Asadzadeh Aghdaei, Hamid, Hamblin, Michael R., Yadegar, Abbas, Rad-Malekshahi, Mazda, Zali, Mohammad Reza, Llopis-Lorente, Antoni|||0000-0002-6987-9506
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/203416
Acceso en línea:https://riunet.upv.es/handle/10251/203416
Access Level:acceso abierto
Palabra clave:H. pylori
Antibiotic therapy
Biopharmaceutical principles
Pharmaceutical microbiology
Pharmacodynamics
Pharmacokinetics
Descripción
Sumario:[EN] Helicobacter pylori (H. pylori) is a notorious, recalcitrant and silent germ, which can cause a variety of debilitating stomach diseases, including gastric and duodenal ulcers and gastric cancer. This microbe predominantly colonizes the mucosal layer of the human stomach and survives in the inhospitable gastric microenvironment, by adapting to this hostile milieu. In this review, we first discuss H. pylori colonization and invasion. Thereafter, we provide a survey of current curative options based on polypharmacy, looking at pharmacokinetics, pharmacodynamics and pharmaceutical microbiology concepts, in the battle against H. pylori infection.

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