Communicating genome architecture: biovisualization of the genome, from data analysis and hypothesis generation to communication and learning
Genome discoveries at the core of biology are made by visual description and exploration of the cell, from microscopic sketches and biochemical mapping to computational analysis and spatial modeling. We outline the experimental and visualization techniques that have been developed recently which cap...
| Autores: | , |
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| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/42308 |
| Acesso em linha: | http://hdl.handle.net/10230/42308 http://dx.doi.org/10.1016/j.jmb.2018.11.008 |
| Access Level: | acceso abierto |
| Palavra-chave: | Genome architecture Molecular visualization 3D modeling Multiscale genomics 4D Nucleome |
| Resumo: | Genome discoveries at the core of biology are made by visual description and exploration of the cell, from microscopic sketches and biochemical mapping to computational analysis and spatial modeling. We outline the experimental and visualization techniques that have been developed recently which capture the three-dimensional interactions regulating how genes are expressed. We detail the challenges faced in integration of the data to portray the components and organization and their dynamic landscape. The goal is more than a single data-driven representation as interactive visualization for de novo research is paramount to decipher insights on genome organization in space. |
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