Inhibition of Sema-3A Promotes Cell Migration, Axonal Growth, and Retinal Ganglion Cell Survival

Semaphorin 3A (Sema-3A) is a secreted protein that deflects axons from inappropriate regions and induces neuronal cell death. Intravitreal application of polyclonal antibodies against Sema-3A prevents loss of retinal ganglion cells ensuing from axotomy of optic nerves. This suggested a therapeutic a...

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Detalles Bibliográficos
Autores: Nitzan, Anat, Corredor, Miriam, Galron, Ronit, Nahary, Limor, Safrin, Mary, Bruzel, Marina, Moure, Alejandra, Bonet, Roman, Pérez, Yolanda, Bujons, Jordi, Vallejo-Yague, Enriqueta, Sacks, Hagit, Burnet, Michael, Alfonso, Ignacio, Messeguer Peypoch, Ángel, Benhar, Itai, Barzilai, Ari, Solomon, Arieh S
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/257602
Acceso en línea:http://hdl.handle.net/10261/257602
https://api.elsevier.com/content/abstract/scopus_id/85122166593
Access Level:acceso abierto
Palabra clave:Semaphorin 3A
Descripción
Sumario:Semaphorin 3A (Sema-3A) is a secreted protein that deflects axons from inappropriate regions and induces neuronal cell death. Intravitreal application of polyclonal antibodies against Sema-3A prevents loss of retinal ganglion cells ensuing from axotomy of optic nerves. This suggested a therapeutic approach for neuroprotection via inhibition of the Sema-3A pathway.

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