Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status
Mamografia; Menopausa; Obesitat
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/6950 |
| Acceso en línea: | https://hdl.handle.net/11351/6950 http://hdl.handle.net/11351/6950 |
| Access Level: | acceso abierto |
| Palabra clave: | Mama - Càncer Obesitat - Complicacions Menopausa DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms DISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity Other subheadings::Other subheadings::Other subheadings::/complications PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Climacteric::Menopause ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama ENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::climaterio::menopausia |
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Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status |
| title |
Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status |
| spellingShingle |
Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status García-Estévez, Laura Mama - Càncer Obesitat - Complicacions Menopausa DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms DISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity Other subheadings::Other subheadings::Other subheadings::/complications PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Climacteric::Menopause ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama ENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::climaterio::menopausia |
| title_short |
Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status |
| title_full |
Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status |
| title_fullStr |
Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status |
| title_full_unstemmed |
Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status |
| title_sort |
Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status |
| dc.creator.none.fl_str_mv |
García-Estévez, Laura Cortés Castan, Javier Pérez, Silvia Calvo, Isabel Gallegos, Isabel Moreno-Bueno, Gema |
| author |
García-Estévez, Laura |
| author_facet |
García-Estévez, Laura Cortés Castan, Javier Pérez, Silvia Calvo, Isabel Gallegos, Isabel Moreno-Bueno, Gema |
| author_role |
author |
| author2 |
Cortés Castan, Javier Pérez, Silvia Calvo, Isabel Gallegos, Isabel Moreno-Bueno, Gema |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [García-Estévez L] Breast Cancer Department, MD Anderson Cancer Center, Madrid, Spain. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. [Cortés J] International Breast Cancer Center (IBCC), Barcelona, Spain. Medical Scientia Innovation Research (MedSIR), Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Pérez S, Calvo I, Gallegos I] Breast Cancer Department, MD Anderson Cancer Center, Madrid, Spain. [Moreno-Bueno G] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas ‘Alberto Sols’ (CSIC-UAM), IdiPaz, & Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. MD Anderson International Foundation, Madrid, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Mama - Càncer Obesitat - Complicacions Menopausa DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms DISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity Other subheadings::Other subheadings::Other subheadings::/complications PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Climacteric::Menopause ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama ENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::climaterio::menopausia |
| topic |
Mama - Càncer Obesitat - Complicacions Menopausa DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms DISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity Other subheadings::Other subheadings::Other subheadings::/complications PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Climacteric::Menopause ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama ENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::climaterio::menopausia |
| description |
Mamografia; Menopausa; Obesitat |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/11351/6950 http://hdl.handle.net/11351/6950 |
| url |
https://hdl.handle.net/11351/6950 http://hdl.handle.net/11351/6950 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Frontiers in Oncology;11 https://doi.org/10.3389/fonc.2021.705911 |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869403034388267008 |
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Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal StatusGarcía-Estévez, LauraCortés Castan, JavierPérez, SilviaCalvo, IsabelGallegos, IsabelMoreno-Bueno, GemaMama - CàncerObesitat - ComplicacionsMenopausaDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsDISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::ObesityOther subheadings::Other subheadings::Other subheadings::/complicationsPHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Climacteric::MenopauseENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidadOtros calificadores::Otros calificadores::Otros calificadores::/complicacionesFENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::climaterio::menopausiaMamografia; Menopausa; ObesitatMamografía; Menopausia; ObesidadMammogram; Menopause; ObesityBreast cancer is the most common tumor in women worldwide, and an increasing public health concern. Knowledge of both protective and negative risk factors is essential for a better understanding of this heterogenous disease. We undertook a review of the recent literature and evaluated the relationship between obesity mediators and breast cancer development depending on menopausal status. Excess weight is now pandemic and has replaced tobacco as the main lifestyle-related risk factor for premature death. Although the prevalence of obesity/overweight has increased globally over the last 50 years, the potential harm attributable to excess fat has generally been underestimated. The relationship between overweight/obesity, breast cancer and overall risk appears to be highly dependent on menopausal status. Thus, obesity increases the risk of breast cancer in postmenopausal women but, conversely, it appears to be protective in premenopausal women. We evaluate the role of different clinical factors potentially involved in this seemingly contradictory relationship, including estrogen, mammogram density, adipokines, insulin-signaling pathway activation, and inflammatory status. A key focus of this review is to better understand the impact of body mass index and menopausal status on these clinical factors and, hence, provide some clarity into the inter-relationships involved in this controversial issue.This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Frontiers MediaInstitut Català de la Salut[García-Estévez L] Breast Cancer Department, MD Anderson Cancer Center, Madrid, Spain. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. [Cortés J] International Breast Cancer Center (IBCC), Barcelona, Spain. Medical Scientia Innovation Research (MedSIR), Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Pérez S, Calvo I, Gallegos I] Breast Cancer Department, MD Anderson Cancer Center, Madrid, Spain. [Moreno-Bueno G] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas ‘Alberto Sols’ (CSIC-UAM), IdiPaz, & Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. MD Anderson International Foundation, Madrid, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/6950http://hdl.handle.net/11351/6950Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Oncology;11https://doi.org/10.3389/fonc.2021.705911Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/69502026-05-29T05:05:01Z |
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15,812455 |