Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients
Haplotipos; Enfermedades infecciosas; Mutación
| Autores: | , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/5989 |
| Acceso en línea: | https://hdl.handle.net/11351/5989 |
| Access Level: | acceso abierto |
| Palabra clave: | Genètica vírica Virus de l'hepatitis B PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Quasispecies Other subheadings::Other subheadings::Other subheadings::/genetics DISEASES::Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, Chronic FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::cuasiespecies Otros calificadores::Otros calificadores::Otros calificadores::/genética ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Hepadnaviridae::hepatitis B::hepatitis B crónica |
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| dc.title.none.fl_str_mv |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients |
| title |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients |
| spellingShingle |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients Gonzalez Fernandez, Carolina Genètica vírica Virus de l'hepatitis B PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Quasispecies Other subheadings::Other subheadings::Other subheadings::/genetics DISEASES::Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, Chronic FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::cuasiespecies Otros calificadores::Otros calificadores::Otros calificadores::/genética ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Hepadnaviridae::hepatitis B::hepatitis B crónica |
| title_short |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients |
| title_full |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients |
| title_fullStr |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients |
| title_full_unstemmed |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients |
| title_sort |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients |
| dc.creator.none.fl_str_mv |
Gonzalez Fernandez, Carolina Casillas Gomez, Rosario Carioti, Luca Guerrero Murillo, Mercedes Riveiro Barciela, Maria del Mar Godoy Cruz, Cristina Sopena Santisteve, Sara Yll Pico, Marçal Quer Sivila, Josep Lopez Martinez, Rosa Pacín Ruíz, Beatriz García García, Selene Esteban Mur, Rafael Tabernero Caellas, David Rodríguez Frias, Francisco Rando Segura, Ariadna Gregori Font, Josep Cortese, Maria Francesca Buti Ferret, Maria |
| author |
Gonzalez Fernandez, Carolina |
| author_facet |
Gonzalez Fernandez, Carolina Casillas Gomez, Rosario Carioti, Luca Guerrero Murillo, Mercedes Riveiro Barciela, Maria del Mar Godoy Cruz, Cristina Sopena Santisteve, Sara Yll Pico, Marçal Quer Sivila, Josep Lopez Martinez, Rosa Pacín Ruíz, Beatriz García García, Selene Esteban Mur, Rafael Tabernero Caellas, David Rodríguez Frias, Francisco Rando Segura, Ariadna Gregori Font, Josep Cortese, Maria Francesca Buti Ferret, Maria |
| author_role |
author |
| author2 |
Casillas Gomez, Rosario Carioti, Luca Guerrero Murillo, Mercedes Riveiro Barciela, Maria del Mar Godoy Cruz, Cristina Sopena Santisteve, Sara Yll Pico, Marçal Quer Sivila, Josep Lopez Martinez, Rosa Pacín Ruíz, Beatriz García García, Selene Esteban Mur, Rafael Tabernero Caellas, David Rodríguez Frias, Francisco Rando Segura, Ariadna Gregori Font, Josep Cortese, Maria Francesca Buti Ferret, Maria |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Cortese MF, Casillas R, Sopena S, Yll M] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [González C, Rando A, Lopez-Martinez R] Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Gregori J] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Roche Diagnostics SL, Sant Cugat del Vallès, Spain. [Carioti L] Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. [Guerrero-Murillo M] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Riveiro-Barciela M, Esteban-Mur R, Buti M] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Godoy C, Tabernero D, Rodríguez-Frías F] Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. [Quer J] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. [Pacín Ruiz B, García-García S] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Genètica vírica Virus de l'hepatitis B PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Quasispecies Other subheadings::Other subheadings::Other subheadings::/genetics DISEASES::Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, Chronic FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::cuasiespecies Otros calificadores::Otros calificadores::Otros calificadores::/genética ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Hepadnaviridae::hepatitis B::hepatitis B crónica |
| topic |
Genètica vírica Virus de l'hepatitis B PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Quasispecies Other subheadings::Other subheadings::Other subheadings::/genetics DISEASES::Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, Chronic FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::cuasiespecies Otros calificadores::Otros calificadores::Otros calificadores::/genética ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Hepadnaviridae::hepatitis B::hepatitis B crónica |
| description |
Haplotipos; Enfermedades infecciosas; Mutación |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/5989 |
| url |
https://hdl.handle.net/11351/5989 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Scientific Reports;11 https://www.nature.com/articles/s41598-021-83762-4 info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F00856 info:eu-repo/grantAgreement/ES/PE2013-2016/PI18&2F01436 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Research |
| publisher.none.fl_str_mv |
Nature Research |
| dc.source.none.fl_str_mv |
Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869403031056941056 |
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Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patientsGonzalez Fernandez, CarolinaCasillas Gomez, RosarioCarioti, LucaGuerrero Murillo, MercedesRiveiro Barciela, Maria del MarGodoy Cruz, CristinaSopena Santisteve, SaraYll Pico, MarçalQuer Sivila, JosepLopez Martinez, RosaPacín Ruíz, BeatrizGarcía García, SeleneEsteban Mur, RafaelTabernero Caellas, DavidRodríguez Frias, FranciscoRando Segura, AriadnaGregori Font, JosepCortese, Maria FrancescaButi Ferret, MariaGenètica víricaVirus de l'hepatitis BPHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::QuasispeciesOther subheadings::Other subheadings::Other subheadings::/geneticsDISEASES::Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, ChronicFENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::cuasiespeciesOtros calificadores::Otros calificadores::Otros calificadores::/genéticaENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Hepadnaviridae::hepatitis B::hepatitis B crónicaHaplotipos; Enfermedades infecciosas; MutaciónHaplotips; Enfermetats infeccioses; MutacióHaplotypes; Infectious diseases; MutationPatients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication. Here, we analyzed the viral quasispecies at the 5′ end of HBX in CI patients and compared it with that of patients in other clinical stages. Fifty-eight HBeAg-negative patients were included: 16 CI, 19 chronic hepatitis B, 16 hepatocellular carcinoma and 6 liver cirrhosis. Quasispecies complexity and conservation were determined in the region between nucleotides 1255 and 1611. Amino acid changes detected were tested in vitro. CI patients showed higher complexity in terms of mutation frequency and nucleotide diversity and higher quasispecies conservation (p < 0.05). A genotype D-specific pattern of mutations (A12S/P33S/P46S/T36D-G) was identified in CI (median frequency, 81.7%), which determined a reduction in HBV DNA release of up to 1.5 log in vitro. CI patients showed a more complex and conserved viral quasispecies than the other groups. The genotype-specific pattern of mutations could partially explain the low viremia observed in these patients.This study was supported by grants from the Institute of Health Carlos III (grant PI15/00856 and PI18/01436) and co-financed by the European Regional Development Fund (ERDF).Nature ResearchInstitut Català de la Salut[Cortese MF, Casillas R, Sopena S, Yll M] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [González C, Rando A, Lopez-Martinez R] Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Gregori J] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Roche Diagnostics SL, Sant Cugat del Vallès, Spain. [Carioti L] Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. [Guerrero-Murillo M] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Riveiro-Barciela M, Esteban-Mur R, Buti M] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Godoy C, Tabernero D, Rodríguez-Frías F] Unitat de Patologia Hepàtica, Servei de Bioquímica i Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. [Quer J] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto De Salud Carlos III, Madrid, Spain. [Pacín Ruiz B, García-García S] Liver Unit, Liver Disease Laboratory Viral Hepatitis, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/5989Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésScientific Reports;11https://www.nature.com/articles/s41598-021-83762-4info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F00856info:eu-repo/grantAgreement/ES/PE2013-2016/PI18&2F01436Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/59892026-05-29T05:05:01Z |
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