Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research
Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a progressive loss of the IVD structure and functionality, leading to severe impairments with restricted treatment options due to the highly demanding mechanical exposure of the IVD. Degenerative changes...
| Autores: | , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/46714 |
| Acesso em linha: | http://hdl.handle.net/10230/46714 http://dx.doi.org/10.3390/ijms22020703 |
| Access Level: | acceso abierto |
| Palavra-chave: | Intervertebral disc Extracellular matrix Disc cell molecular biology Multifactorial cell stimulation Intervertebral disc degeneration Regenerative medicine Multiscale modeling Computational multiphysics Computational systems biology |
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Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative researchBaumgartner, LauraWuertz-Kozak, KarinLe Maitre, Christine L.Wignall, FrancisRichardson, Stephen M.Hoyland, JudithRuiz Wills, CarlosGonzález Ballester, Miguel Ángel, 1973-Neidlin, MichaelAlexopoulos, Leonidas G.Noailly, JérômeIntervertebral discExtracellular matrixDisc cell molecular biologyMultifactorial cell stimulationIntervertebral disc degenerationRegenerative medicineMultiscale modelingComputational multiphysicsComputational systems biologyIntervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a progressive loss of the IVD structure and functionality, leading to severe impairments with restricted treatment options due to the highly demanding mechanical exposure of the IVD. Degenerative changes in the IVD usually increase with age but at an accelerated rate in some individuals. To understand the initiation and progression of this disease, it is crucial to identify key top-down and bottom-up regulations’ processes, across the cell, tissue, and organ levels, in health and disease. Owing to unremitting investigation of experimental research, the comprehension of detailed cell signaling pathways and their effect on matrix turnover significantly rose. Likewise, in silico research substantially contributed to a holistic understanding of spatiotemporal effects and complex, multifactorial interactions within the IVD. Together with important achievements in the research of biomaterials, manifold promising approaches for regenerative treatment options were presented over the last years. This review provides an integrative analysis of the current knowledge about (1) the multiscale function and regulation of the IVD in health and disease, (2) the possible regenerative strategies, and (3) the in silico models that shall eventually support the development of advanced therapiesM.N. acknowledges financial support from the German Research Foundation (DFG) via the scholarship “Forschungsstipendium” (PN: 387071423). L.G.A. acknowledges funding through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH–CREATE–INNOVATE co-financed by the European Union and Greek national funds (Project Code: T1EDK-02829). K.W. acknowledges funding from the Swiss National Science Foundation (SNF PP00P2_163678/1). L.B., C.R.W., M.A.G.B., and J.N. acknowledge financial support from the Spanish Ministry of Science and Innovation (HOLOA-DPI2016-80283-C2-1-R, RYC-2015-18888). L.B., C.L.M., C.R.W., L.G.A., M.A.G.B., and J.N. further acknowledge financial support from the European Commission (Disc4All-H2020-MSCA-ITN-ETN-2020 GA: 955735).MDPI202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/46714http://dx.doi.org/10.3390/ijms22020703reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInt J Mol Sci. 2021 Jan 12;22(2):703info:eu-repo/grantAgreement/ES/1PE/DPI2016-80283-C2-1-Rinfo:eu-repo/grantAgreement/ES/1PE/RYC2015-18888info:eu-repo/grantAgreement/EC/H2020/955735© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/467142026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research |
| title |
Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research |
| spellingShingle |
Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research Baumgartner, Laura Intervertebral disc Extracellular matrix Disc cell molecular biology Multifactorial cell stimulation Intervertebral disc degeneration Regenerative medicine Multiscale modeling Computational multiphysics Computational systems biology |
| title_short |
Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research |
| title_full |
Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research |
| title_fullStr |
Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research |
| title_full_unstemmed |
Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research |
| title_sort |
Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research |
| dc.creator.none.fl_str_mv |
Baumgartner, Laura Wuertz-Kozak, Karin Le Maitre, Christine L. Wignall, Francis Richardson, Stephen M. Hoyland, Judith Ruiz Wills, Carlos González Ballester, Miguel Ángel, 1973- Neidlin, Michael Alexopoulos, Leonidas G. Noailly, Jérôme |
| author |
Baumgartner, Laura |
| author_facet |
Baumgartner, Laura Wuertz-Kozak, Karin Le Maitre, Christine L. Wignall, Francis Richardson, Stephen M. Hoyland, Judith Ruiz Wills, Carlos González Ballester, Miguel Ángel, 1973- Neidlin, Michael Alexopoulos, Leonidas G. Noailly, Jérôme |
| author_role |
author |
| author2 |
Wuertz-Kozak, Karin Le Maitre, Christine L. Wignall, Francis Richardson, Stephen M. Hoyland, Judith Ruiz Wills, Carlos González Ballester, Miguel Ángel, 1973- Neidlin, Michael Alexopoulos, Leonidas G. Noailly, Jérôme |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Intervertebral disc Extracellular matrix Disc cell molecular biology Multifactorial cell stimulation Intervertebral disc degeneration Regenerative medicine Multiscale modeling Computational multiphysics Computational systems biology |
| topic |
Intervertebral disc Extracellular matrix Disc cell molecular biology Multifactorial cell stimulation Intervertebral disc degeneration Regenerative medicine Multiscale modeling Computational multiphysics Computational systems biology |
| description |
Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a progressive loss of the IVD structure and functionality, leading to severe impairments with restricted treatment options due to the highly demanding mechanical exposure of the IVD. Degenerative changes in the IVD usually increase with age but at an accelerated rate in some individuals. To understand the initiation and progression of this disease, it is crucial to identify key top-down and bottom-up regulations’ processes, across the cell, tissue, and organ levels, in health and disease. Owing to unremitting investigation of experimental research, the comprehension of detailed cell signaling pathways and their effect on matrix turnover significantly rose. Likewise, in silico research substantially contributed to a holistic understanding of spatiotemporal effects and complex, multifactorial interactions within the IVD. Together with important achievements in the research of biomaterials, manifold promising approaches for regenerative treatment options were presented over the last years. This review provides an integrative analysis of the current knowledge about (1) the multiscale function and regulation of the IVD in health and disease, (2) the possible regenerative strategies, and (3) the in silico models that shall eventually support the development of advanced therapies |
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2021 |
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2021 2021 2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/46714 http://dx.doi.org/10.3390/ijms22020703 |
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http://hdl.handle.net/10230/46714 http://dx.doi.org/10.3390/ijms22020703 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Int J Mol Sci. 2021 Jan 12;22(2):703 info:eu-repo/grantAgreement/ES/1PE/DPI2016-80283-C2-1-R info:eu-repo/grantAgreement/ES/1PE/RYC2015-18888 info:eu-repo/grantAgreement/EC/H2020/955735 |
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https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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MDPI |
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MDPI |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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