Tuberous sclerosis complex with oral manifestations: A case report and literature review

Introduction: Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome produced by a number of genetic mutations. The disease is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas, gingival hyperplasia and...

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Autores: Harutunian, Karmen, Barbosa de Figueiredo, Rui Pedro, Gay Escoda, Cosme
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/44734
Acceso en línea:https://hdl.handle.net/2445/44734
Access Level:acceso abierto
Palabra clave:Tumors
Malalties de la boca
Esclerosi tuberosa
Fibromes
Mouth diseases
Tuberosis sclerosis
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spelling Tuberous sclerosis complex with oral manifestations: A case report and literature reviewHarutunian, KarmenBarbosa de Figueiredo, Rui PedroGay Escoda, CosmeTumorsMalalties de la bocaEsclerosi tuberosaFibromesTumorsMouth diseasesTuberosis sclerosisIntroduction: Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome produced by a number of genetic mutations. The disease is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas, gingival hyperplasia and enamel hypoplasia. Clinical Case: A 35-year-old woman diagnosed with TSC presented with a reactive fibroma of considerable size and rapid growth in the region of the right lower third molar. Discussion: In the present case the association of TSC with dental malpositioning gave rise to a rapidly evolving reactive fibroma of considerable diameter. Few similar cases can be found in the literature. Patients with TSC present mutations of the TSC1 and TSC2 genes, which intervene in cell cycle regulation and are important for avoiding neoplastic processes. No studies have been found associating TSC with an increased risk of oral cancer, though it has been shown that the over-expression of TSC2 could exert an antitumor effect. Careful oral and dental hygiene, together with regular visits to the dentist, are needed for the prevention and early detection of any type of oral lesion. The renal, pulmonary and cardiac alterations often seen in TSC must be taken into account for the correct management of these patients.Medicina Oral SL2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/44734Articles publicats en revistes (Odontoestomatologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/doi:10.4317/medoral.16.e478Medicina Oral, Patología Oral y Cirugia Bucal, 2011, vol. 16, num. 4, p. 478-481http://dx.doi.org/doi:10.4317/medoral.16.e478(c) Medicina Oral SL, 2011info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/447342026-05-27T06:46:51Z
dc.title.none.fl_str_mv Tuberous sclerosis complex with oral manifestations: A case report and literature review
title Tuberous sclerosis complex with oral manifestations: A case report and literature review
spellingShingle Tuberous sclerosis complex with oral manifestations: A case report and literature review
Harutunian, Karmen
Tumors
Malalties de la boca
Esclerosi tuberosa
Fibromes
Tumors
Mouth diseases
Tuberosis sclerosis
title_short Tuberous sclerosis complex with oral manifestations: A case report and literature review
title_full Tuberous sclerosis complex with oral manifestations: A case report and literature review
title_fullStr Tuberous sclerosis complex with oral manifestations: A case report and literature review
title_full_unstemmed Tuberous sclerosis complex with oral manifestations: A case report and literature review
title_sort Tuberous sclerosis complex with oral manifestations: A case report and literature review
dc.creator.none.fl_str_mv Harutunian, Karmen
Barbosa de Figueiredo, Rui Pedro
Gay Escoda, Cosme
author Harutunian, Karmen
author_facet Harutunian, Karmen
Barbosa de Figueiredo, Rui Pedro
Gay Escoda, Cosme
author_role author
author2 Barbosa de Figueiredo, Rui Pedro
Gay Escoda, Cosme
author2_role author
author
dc.subject.none.fl_str_mv Tumors
Malalties de la boca
Esclerosi tuberosa
Fibromes
Tumors
Mouth diseases
Tuberosis sclerosis
topic Tumors
Malalties de la boca
Esclerosi tuberosa
Fibromes
Tumors
Mouth diseases
Tuberosis sclerosis
description Introduction: Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome produced by a number of genetic mutations. The disease is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas, gingival hyperplasia and enamel hypoplasia. Clinical Case: A 35-year-old woman diagnosed with TSC presented with a reactive fibroma of considerable size and rapid growth in the region of the right lower third molar. Discussion: In the present case the association of TSC with dental malpositioning gave rise to a rapidly evolving reactive fibroma of considerable diameter. Few similar cases can be found in the literature. Patients with TSC present mutations of the TSC1 and TSC2 genes, which intervene in cell cycle regulation and are important for avoiding neoplastic processes. No studies have been found associating TSC with an increased risk of oral cancer, though it has been shown that the over-expression of TSC2 could exert an antitumor effect. Careful oral and dental hygiene, together with regular visits to the dentist, are needed for the prevention and early detection of any type of oral lesion. The renal, pulmonary and cardiac alterations often seen in TSC must be taken into account for the correct management of these patients.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/44734
url https://hdl.handle.net/2445/44734
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/doi:10.4317/medoral.16.e478
Medicina Oral, Patología Oral y Cirugia Bucal, 2011, vol. 16, num. 4, p. 478-481
http://dx.doi.org/doi:10.4317/medoral.16.e478
dc.rights.none.fl_str_mv (c) Medicina Oral SL, 2011
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Medicina Oral SL, 2011
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Medicina Oral SL
publisher.none.fl_str_mv Medicina Oral SL
dc.source.none.fl_str_mv Articles publicats en revistes (Odontoestomatologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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