Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative
Background: Mental disorders are highly prevalent among students worldwide. This study aims to examine comorbidity and temporal associations between mental disorders among students. Methods: The study included 72,288 students from 18 countries as part of the World Mental Health International College...
| Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2025 |
| Country: | España |
| Institution: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repository: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p19343 |
| Online Access: | https://fisabio.portalinvestigacion.com/publicaciones/19343 |
| Access Level: | Open access |
| Keyword: | Internalizing Externalizing Comorbidity College students Substance use disorders |
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Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiativeRoest, Annelieke M.de Vries, Ymkje AnnaPozuelo, Julia R.Petukhova, Maria V.Lee, SueSampson, Nancy A.Albor, YesicaAlhadi, Ahmad N.Alonso, JordiAl-Saud, NoufAltwaijri, YasminAndersson, ClaesAtwoli, LukoyeAuerbach, Randy P.Muaka, Caroline AyuyaBaez-Mansur, Patricia M.Ballester, LauraBantjes, JasonBaumeister, HaraldBendtsen, MarcusBenjet, CorinaBerman, Anne H.Bruffaerts, RonnyCarrasco, PaulaChan, Silver C. N.Cohut, IrinaCouder, Maria Anabell Covarrubias DiazCrockett, Marcelo A.Cuijpers, PimDavid, Oana A.Dong, DongEbert, David D.Gaete, JorgeForero, Carlos GarciaGili, MargalidaGutierrez-Garcia, RaulHaro, Josep MariaHasking, PenelopeHunt, XantheHusky, Mathilde M.Jaguga, FlorenceLanger, Alvaro I.Leniz, IreneLiu, YanMac-Ginty, ScarlettMartinez, VaniaMcLafferty, MargaretMiranda, AndreaMonroy-Velasco, Iris RubyMurray, Elaine K.Musyoka, Catherine M.Nedelcea, CatalinNunez, DanielO'Neill, Siobhan M.Piqueras, Jose A.Popescu, Codruta A.Prescivalli, Ana PaulaRapsey, CharleneRobinson, KealaghRodriguez-Jimenez, TiscarSaal, WyleneSiu, Oi-LingStein, Dan J.Struijs, Sascha Y.Tomoiaga, Cristina T.Valdes-Garcia, Karla PatriciaVargas-Contreras, EuniceVigo, Daniel V.Wang, Angel Y.Wong, Samuel Y. S.Kessler, Ronald C.InternalizingExternalizingComorbidityCollege studentsSubstance use disordersBackground: Mental disorders are highly prevalent among students worldwide. This study aims to examine comorbidity and temporal associations between mental disorders among students. Methods: The study included 72,288 students from 18 countries as part of the World Mental Health International College Student (WMH-ICS) Initiative, with cross-sectional data collected between 2017 and 2023. Screening for common DSM-5 disorders was conducted using validated screening measures. Latent variables were examined using exploratory principal axis factor analysis on a correlation matrix among the lifetime mental disorders. Based on age-of-onset information, multivariable poisson regression models were used to examine associations of prior disorders with the first onset of other disorders. Results: 27.0 % of students screened positive for only one lifetime disorder, 17.1 % for two, 10.9 % for three, and 10.6 % for 4+ disorders. In the factor analysis, three latent variables were found, comprising: internalizing disorders (generalized anxiety disorder, major depressive episode, post-traumatic stress disorder, and panic disorder), substance use disorders (drug use disorder and alcohol use disorder), and externalizing disorders (attention deficit/hyperactivity disorder and mania/hypomania). Prior internalizing and externalizing disorders were associated with the subsequent first onset of all other disorders with risk ratios ranging from 1.5-7.5. Substance use disorders were less consistently associated with the subsequent first onset of other disorders, but alcohol use disorder was associated with the first onset of drug use disorder and vice versa. Conclusions: Mental disorder comorbidity is common among students, and students with disorders across the internalizing and externalizing spectrum have an increased risk of future mental disorder comorbidities.ELSEVIER IRELAND LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/19343PSYCHIATRY RESEARCHISSN: 01651781ISSNe: 18727123reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p193432026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative |
| title |
Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative |
| spellingShingle |
Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative Roest, Annelieke M. Internalizing Externalizing Comorbidity College students Substance use disorders |
| title_short |
Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative |
| title_full |
Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative |
| title_fullStr |
Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative |
| title_full_unstemmed |
Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative |
| title_sort |
Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative |
| dc.creator.none.fl_str_mv |
Roest, Annelieke M. de Vries, Ymkje Anna Pozuelo, Julia R. Petukhova, Maria V. Lee, Sue Sampson, Nancy A. Albor, Yesica Alhadi, Ahmad N. Alonso, Jordi Al-Saud, Nouf Altwaijri, Yasmin Andersson, Claes Atwoli, Lukoye Auerbach, Randy P. Muaka, Caroline Ayuya Baez-Mansur, Patricia M. Ballester, Laura Bantjes, Jason Baumeister, Harald Bendtsen, Marcus Benjet, Corina Berman, Anne H. Bruffaerts, Ronny Carrasco, Paula Chan, Silver C. N. Cohut, Irina Couder, Maria Anabell Covarrubias Diaz Crockett, Marcelo A. Cuijpers, Pim David, Oana A. Dong, Dong Ebert, David D. Gaete, Jorge Forero, Carlos Garcia Gili, Margalida Gutierrez-Garcia, Raul Haro, Josep Maria Hasking, Penelope Hunt, Xanthe Husky, Mathilde M. Jaguga, Florence Langer, Alvaro I. Leniz, Irene Liu, Yan Mac-Ginty, Scarlett Martinez, Vania McLafferty, Margaret Miranda, Andrea Monroy-Velasco, Iris Ruby Murray, Elaine K. Musyoka, Catherine M. Nedelcea, Catalin Nunez, Daniel O'Neill, Siobhan M. Piqueras, Jose A. Popescu, Codruta A. Prescivalli, Ana Paula Rapsey, Charlene Robinson, Kealagh Rodriguez-Jimenez, Tiscar Saal, Wylene Siu, Oi-Ling Stein, Dan J. Struijs, Sascha Y. Tomoiaga, Cristina T. Valdes-Garcia, Karla Patricia Vargas-Contreras, Eunice Vigo, Daniel V. Wang, Angel Y. Wong, Samuel Y. S. Kessler, Ronald C. |
| author |
Roest, Annelieke M. |
| author_facet |
Roest, Annelieke M. de Vries, Ymkje Anna Pozuelo, Julia R. Petukhova, Maria V. Lee, Sue Sampson, Nancy A. Albor, Yesica Alhadi, Ahmad N. Alonso, Jordi Al-Saud, Nouf Altwaijri, Yasmin Andersson, Claes Atwoli, Lukoye Auerbach, Randy P. Muaka, Caroline Ayuya Baez-Mansur, Patricia M. Ballester, Laura Bantjes, Jason Baumeister, Harald Bendtsen, Marcus Benjet, Corina Berman, Anne H. Bruffaerts, Ronny Carrasco, Paula Chan, Silver C. N. Cohut, Irina Couder, Maria Anabell Covarrubias Diaz Crockett, Marcelo A. Cuijpers, Pim David, Oana A. Dong, Dong Ebert, David D. Gaete, Jorge Forero, Carlos Garcia Gili, Margalida Gutierrez-Garcia, Raul Haro, Josep Maria Hasking, Penelope Hunt, Xanthe Husky, Mathilde M. Jaguga, Florence Langer, Alvaro I. Leniz, Irene Liu, Yan Mac-Ginty, Scarlett Martinez, Vania McLafferty, Margaret Miranda, Andrea Monroy-Velasco, Iris Ruby Murray, Elaine K. Musyoka, Catherine M. Nedelcea, Catalin Nunez, Daniel O'Neill, Siobhan M. Piqueras, Jose A. Popescu, Codruta A. Prescivalli, Ana Paula Rapsey, Charlene Robinson, Kealagh Rodriguez-Jimenez, Tiscar Saal, Wylene Siu, Oi-Ling Stein, Dan J. Struijs, Sascha Y. Tomoiaga, Cristina T. Valdes-Garcia, Karla Patricia Vargas-Contreras, Eunice Vigo, Daniel V. Wang, Angel Y. Wong, Samuel Y. S. Kessler, Ronald C. |
| author_role |
author |
| author2 |
de Vries, Ymkje Anna Pozuelo, Julia R. Petukhova, Maria V. Lee, Sue Sampson, Nancy A. Albor, Yesica Alhadi, Ahmad N. Alonso, Jordi Al-Saud, Nouf Altwaijri, Yasmin Andersson, Claes Atwoli, Lukoye Auerbach, Randy P. Muaka, Caroline Ayuya Baez-Mansur, Patricia M. Ballester, Laura Bantjes, Jason Baumeister, Harald Bendtsen, Marcus Benjet, Corina Berman, Anne H. Bruffaerts, Ronny Carrasco, Paula Chan, Silver C. N. Cohut, Irina Couder, Maria Anabell Covarrubias Diaz Crockett, Marcelo A. Cuijpers, Pim David, Oana A. Dong, Dong Ebert, David D. Gaete, Jorge Forero, Carlos Garcia Gili, Margalida Gutierrez-Garcia, Raul Haro, Josep Maria Hasking, Penelope Hunt, Xanthe Husky, Mathilde M. Jaguga, Florence Langer, Alvaro I. Leniz, Irene Liu, Yan Mac-Ginty, Scarlett Martinez, Vania McLafferty, Margaret Miranda, Andrea Monroy-Velasco, Iris Ruby Murray, Elaine K. Musyoka, Catherine M. Nedelcea, Catalin Nunez, Daniel O'Neill, Siobhan M. Piqueras, Jose A. Popescu, Codruta A. Prescivalli, Ana Paula Rapsey, Charlene Robinson, Kealagh Rodriguez-Jimenez, Tiscar Saal, Wylene Siu, Oi-Ling Stein, Dan J. Struijs, Sascha Y. Tomoiaga, Cristina T. Valdes-Garcia, Karla Patricia Vargas-Contreras, Eunice Vigo, Daniel V. Wang, Angel Y. Wong, Samuel Y. S. Kessler, Ronald C. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Internalizing Externalizing Comorbidity College students Substance use disorders |
| topic |
Internalizing Externalizing Comorbidity College students Substance use disorders |
| description |
Background: Mental disorders are highly prevalent among students worldwide. This study aims to examine comorbidity and temporal associations between mental disorders among students. Methods: The study included 72,288 students from 18 countries as part of the World Mental Health International College Student (WMH-ICS) Initiative, with cross-sectional data collected between 2017 and 2023. Screening for common DSM-5 disorders was conducted using validated screening measures. Latent variables were examined using exploratory principal axis factor analysis on a correlation matrix among the lifetime mental disorders. Based on age-of-onset information, multivariable poisson regression models were used to examine associations of prior disorders with the first onset of other disorders. Results: 27.0 % of students screened positive for only one lifetime disorder, 17.1 % for two, 10.9 % for three, and 10.6 % for 4+ disorders. In the factor analysis, three latent variables were found, comprising: internalizing disorders (generalized anxiety disorder, major depressive episode, post-traumatic stress disorder, and panic disorder), substance use disorders (drug use disorder and alcohol use disorder), and externalizing disorders (attention deficit/hyperactivity disorder and mania/hypomania). Prior internalizing and externalizing disorders were associated with the subsequent first onset of all other disorders with risk ratios ranging from 1.5-7.5. Substance use disorders were less consistently associated with the subsequent first onset of other disorders, but alcohol use disorder was associated with the first onset of drug use disorder and vice versa. Conclusions: Mental disorder comorbidity is common among students, and students with disorders across the internalizing and externalizing spectrum have an increased risk of future mental disorder comorbidities. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/19343 |
| url |
https://fisabio.portalinvestigacion.com/publicaciones/19343 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
ELSEVIER IRELAND LTD |
| publisher.none.fl_str_mv |
ELSEVIER IRELAND LTD |
| dc.source.none.fl_str_mv |
PSYCHIATRY RESEARCH ISSN: 01651781 ISSNe: 18727123 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| reponame_str |
r-FISABIO. Repositorio Institucional de Producción Científica |
| collection |
r-FISABIO. Repositorio Institucional de Producción Científica |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
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1869403019584471040 |
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15,812429 |