Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment

Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2% worldwide; it is commonly characterized by squamous lesions on the skin that present the typical pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl vinyl ether-alt-mal...

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Detalles Bibliográficos
Autores: Martínez-Ortega, Leticia, Mira, Amalia, Fernández-Carvajal, Asia, Reyes Mateo, Carmen, Mallavia, Ricardo, Falcó, Alberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/375885
Acceso en línea:http://hdl.handle.net/10261/375885
Access Level:acceso abierto
Palabra clave:PMVE/MA
Electrospinning
Nanofibers
Capsaicin
Psoriasis
TRPV1
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spelling Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis TreatmentMartínez-Ortega, LeticiaMira, AmaliaFernández-Carvajal, AsiaReyes Mateo, CarmenMallavia, RicardoFalcó, AlbertoPMVE/MAElectrospinningNanofibersCapsaicinPsoriasisTRPV1Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2% worldwide; it is commonly characterized by squamous lesions on the skin that present the typical pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl vinyl ether-alt-maleic ethyl monoester) (PMVEMA-ES) nanofibers have been designed as a delivery vehicle for three therapeutic agents with palliative properties for the symptoms of this disease (salicylic acid, methyl salicylate, and capsaicin). For such a task, the production of these nanofibers by means of the electrospinning technique has been optimized. Their morphology and size have been characterized by optical microscopy and scanning electron microscopy (SEM). By selecting the optimal conditions to achieve the smallest and most uniform nanofibers, approximate diameters of up to 800–900 nm were obtained. It was also determined that the therapeutic agents that were used were encapsulated with high efficiency. The analysis of their stability over time by GC-MS showed no significant losses of the encapsulated compounds 15 days after their preparation, except in the case of methyl salicylate. Likewise, it was demonstrated that the therapeutic compounds that were encapsulated conserved, and even improved, their capacity to activate the transient receptor potential cation channel 1 (TRPV1) channel, which has been associated with the formation of psoriatic lesions.This research was funded by the Spanish Ministerio de Economía y Competitividad grant numbers MAT-2017-86805-R and MAT-2014-53282-R.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)202520252019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/375885reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//MAT-2017-86805-Rinfo:eu-repo/grantAgreement/MINECO//MAT-2014-53282-RThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/pharmaceutics11010014https://doi.org/10.3390/pharmaceutics11010014Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3758852026-05-22T06:33:51Z
dc.title.none.fl_str_mv Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
spellingShingle Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
Martínez-Ortega, Leticia
PMVE/MA
Electrospinning
Nanofibers
Capsaicin
Psoriasis
TRPV1
title_short Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title_full Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title_fullStr Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title_full_unstemmed Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title_sort Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
dc.creator.none.fl_str_mv Martínez-Ortega, Leticia
Mira, Amalia
Fernández-Carvajal, Asia
Reyes Mateo, Carmen
Mallavia, Ricardo
Falcó, Alberto
author Martínez-Ortega, Leticia
author_facet Martínez-Ortega, Leticia
Mira, Amalia
Fernández-Carvajal, Asia
Reyes Mateo, Carmen
Mallavia, Ricardo
Falcó, Alberto
author_role author
author2 Mira, Amalia
Fernández-Carvajal, Asia
Reyes Mateo, Carmen
Mallavia, Ricardo
Falcó, Alberto
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
dc.subject.none.fl_str_mv PMVE/MA
Electrospinning
Nanofibers
Capsaicin
Psoriasis
TRPV1
topic PMVE/MA
Electrospinning
Nanofibers
Capsaicin
Psoriasis
TRPV1
description Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2% worldwide; it is commonly characterized by squamous lesions on the skin that present the typical pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl vinyl ether-alt-maleic ethyl monoester) (PMVEMA-ES) nanofibers have been designed as a delivery vehicle for three therapeutic agents with palliative properties for the symptoms of this disease (salicylic acid, methyl salicylate, and capsaicin). For such a task, the production of these nanofibers by means of the electrospinning technique has been optimized. Their morphology and size have been characterized by optical microscopy and scanning electron microscopy (SEM). By selecting the optimal conditions to achieve the smallest and most uniform nanofibers, approximate diameters of up to 800–900 nm were obtained. It was also determined that the therapeutic agents that were used were encapsulated with high efficiency. The analysis of their stability over time by GC-MS showed no significant losses of the encapsulated compounds 15 days after their preparation, except in the case of methyl salicylate. Likewise, it was demonstrated that the therapeutic compounds that were encapsulated conserved, and even improved, their capacity to activate the transient receptor potential cation channel 1 (TRPV1) channel, which has been associated with the formation of psoriatic lesions.
publishDate 2019
dc.date.none.fl_str_mv 2019
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/375885
url http://hdl.handle.net/10261/375885
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//MAT-2017-86805-R
info:eu-repo/grantAgreement/MINECO//MAT-2014-53282-R
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/pharmaceutics11010014
https://doi.org/10.3390/pharmaceutics11010014
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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