Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem

Long non-coding RNAs (lncRNAs) are an emerging group of RNAs with a crucial role in cancer pathogenesis. In gastrointestinal cancers, TP53 target 1 (TP53TG1) is an epigenetically regulated lncRNA that represents a promising therapeutic target due to its tumor suppressor properties regulating the p53...

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Autores: Masoumi, Farimah, Saraiva, Sofia M., Bouzo, Belén L., López López, Rafael, Esteller, Manel, Diaz-Lagares, Angel, de la Fuente, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/183080
Acceso en línea:https://hdl.handle.net/2445/183080
Access Level:acceso abierto
Palabra clave:Càncer colorectal
Epigenètica
RNA
Nanomedicina
Colorectal cancer
Epigenetics
Nanomedicine
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spelling Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystemMasoumi, FarimahSaraiva, Sofia M.Bouzo, Belén L.López López, RafaelEsteller, ManelDiaz-Lagares, Angelde la Fuente, MaríaCàncer colorectalEpigenèticaRNANanomedicinaColorectal cancerEpigeneticsRNANanomedicineLong non-coding RNAs (lncRNAs) are an emerging group of RNAs with a crucial role in cancer pathogenesis. In gastrointestinal cancers, TP53 target 1 (TP53TG1) is an epigenetically regulated lncRNA that represents a promising therapeutic target due to its tumor suppressor properties regulating the p53-mediated DNA damage and the intracellular localization of the oncogenic YBX1 protein. However, to translate this finding into the clinic as a gene therapy, it is important to develop effective carriers able to deliver exogenous lncRNAs to the targeted cancer cells. Here, we propose the use of biocompatible sphingomyelin nanosystems comprising DOTAP (DSNs) to carry and deliver a plasmid vector encoding for TP53TG1 (pc(TP53TG1)-DSNs) to a colorectal cancer cell line (HCT-116). DSNs presented a high association capacity and convenient physicochemical properties. In addition, pc(TP53TG1)-DSNs showed anti-tumor activities in vitro, specifically a decrease in the proliferation rate, a diminished colony-forming capacity, and hampered migration and invasiveness of the treated cancer cells. Consequently, the proposed strategy displays a high potential as a therapeutic approach for colorectal cancer. Keywords: long non-coding RNAs; epigenomics; colorectal cancer; nanocarriers; emulsionsMDPI2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/183080Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/pharmaceutics13091507Pharmaceutics, 2021, vol. 13, num. 9, p. 1507-1522https://doi.org/10.3390/pharmaceutics13091507cc-by (c) Masoumi, Farimah et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1830802026-05-29T05:05:01Z
dc.title.none.fl_str_mv Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
title Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
spellingShingle Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
Masoumi, Farimah
Càncer colorectal
Epigenètica
RNA
Nanomedicina
Colorectal cancer
Epigenetics
RNA
Nanomedicine
title_short Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
title_full Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
title_fullStr Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
title_full_unstemmed Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
title_sort Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem
dc.creator.none.fl_str_mv Masoumi, Farimah
Saraiva, Sofia M.
Bouzo, Belén L.
López López, Rafael
Esteller, Manel
Diaz-Lagares, Angel
de la Fuente, María
author Masoumi, Farimah
author_facet Masoumi, Farimah
Saraiva, Sofia M.
Bouzo, Belén L.
López López, Rafael
Esteller, Manel
Diaz-Lagares, Angel
de la Fuente, María
author_role author
author2 Saraiva, Sofia M.
Bouzo, Belén L.
López López, Rafael
Esteller, Manel
Diaz-Lagares, Angel
de la Fuente, María
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer colorectal
Epigenètica
RNA
Nanomedicina
Colorectal cancer
Epigenetics
RNA
Nanomedicine
topic Càncer colorectal
Epigenètica
RNA
Nanomedicina
Colorectal cancer
Epigenetics
RNA
Nanomedicine
description Long non-coding RNAs (lncRNAs) are an emerging group of RNAs with a crucial role in cancer pathogenesis. In gastrointestinal cancers, TP53 target 1 (TP53TG1) is an epigenetically regulated lncRNA that represents a promising therapeutic target due to its tumor suppressor properties regulating the p53-mediated DNA damage and the intracellular localization of the oncogenic YBX1 protein. However, to translate this finding into the clinic as a gene therapy, it is important to develop effective carriers able to deliver exogenous lncRNAs to the targeted cancer cells. Here, we propose the use of biocompatible sphingomyelin nanosystems comprising DOTAP (DSNs) to carry and deliver a plasmid vector encoding for TP53TG1 (pc(TP53TG1)-DSNs) to a colorectal cancer cell line (HCT-116). DSNs presented a high association capacity and convenient physicochemical properties. In addition, pc(TP53TG1)-DSNs showed anti-tumor activities in vitro, specifically a decrease in the proliferation rate, a diminished colony-forming capacity, and hampered migration and invasiveness of the treated cancer cells. Consequently, the proposed strategy displays a high potential as a therapeutic approach for colorectal cancer. Keywords: long non-coding RNAs; epigenomics; colorectal cancer; nanocarriers; emulsions
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183080
url https://hdl.handle.net/2445/183080
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics13091507
Pharmaceutics, 2021, vol. 13, num. 9, p. 1507-1522
https://doi.org/10.3390/pharmaceutics13091507
dc.rights.none.fl_str_mv cc-by (c) Masoumi, Farimah et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Masoumi, Farimah et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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