Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)

Dobaño, Carlota, 1969-; Sánchez, Lina; Vidal, Marta; Jairoce, Chenjerai Tobias Sixpence; Aguilar, Ruth; Ubillos, Itziar; Cuamba, Inocencia; Nhabomba, Augusto J.; Williams, Nana Aba; Diez-Padrisa, Núria; Cavanagh, David; Angov, Evelina; Coppel, Ross L.; Gaur, Deepak; Beeson, James G.; Dutta, Sheetij; Aide, Pedro Carlos Paulino; Campo, Joseph J.; Moncunill Piñas, Gemma

Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)

Study of immune correlates against malaria after vaccination with RTS,S/ASO1E: a comphrensive immunological arm of a Phase III double-blind, randomize, controlled multi-centre trial (MAL067).

Detalhes bibliográficos
Autores:	Dobaño, Carlota, 1969-, Sánchez, Lina, Vidal, Marta, Jairoce, Chenjerai Tobias Sixpence, Aguilar, Ruth, Ubillos, Itziar, Cuamba, Inocencia, Nhabomba, Augusto J., Williams, Nana Aba, Diez-Padrisa, Núria, Cavanagh, David, Angov, Evelina, Coppel, Ross L., Gaur, Deepak, Beeson, James G., Dutta, Sheetij, Aide, Pedro Carlos Paulino, Campo, Joseph J., Moncunill Piñas, Gemma
Formato:	conjunto de datos
Fecha de publicación:	2020
País:	España
Recursos:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/164777
Acesso em linha:	https://hdl.handle.net/2445/164777
Access Level:	acceso abierto
Palavra-chave:	Vacuna de la malària Plasmodium falciparum Moçambic Malaria vaccine Mozambique

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spelling	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)Dobaño, Carlota, 1969-Sánchez, LinaVidal, MartaJairoce, Chenjerai Tobias SixpenceAguilar, RuthUbillos, ItziarCuamba, InocenciaNhabomba, Augusto J.Williams, Nana AbaDiez-Padrisa, NúriaCavanagh, DavidAngov, EvelinaCoppel, Ross L.Gaur, DeepakBeeson, James G.Dutta, SheetijAide, Pedro Carlos PaulinoCampo, Joseph J.Moncunill Piñas, GemmaVacuna de la malàriaPlasmodium falciparumMoçambicMalaria vaccinePlasmodium falciparumMozambiqueStudy of immune correlates against malaria after vaccination with RTS,S/ASO1E: a comphrensive immunological arm of a Phase III double-blind, randomize, controlled multi-centre trial (MAL067).Dades primàries associades a l'article publicat a NPJ Vaccines, vol. 5 [https://doi.org/10.1038/s41541-020-0192-7]The RTS,S/AS01E vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 26 clinical trial using a 3-dose immunization schedule. A fourth dose 18 months after the primary 27 vaccination was shown to restore the waning efficacy. However, only total IgG against the 28 immunodominant malaria vaccine epitope has been analyzed following the booster. To better 29 characterize the magnitude, nature and longevity of the immune response to the booster, we 30 measured levels of total IgM, IgG and IgG1-4 subclasses against three constructs of the 31 circumsporozoite protein (CSP) and the hepatitis B surface antigen (HBsAg, also present in RTS,S) 32 by quantitative suspension array technology in 50 subjects in the phase 3 trial in Manhiça, 33 Mozambique. To explore the impact of vaccination on naturally acquired immune responses, we 34 measured antibodies to P. falciparum antigens not included in RTS,S. We found increased IgG, 35 IgG1, IgG3 and IgG4, but not IgG2 nor IgM, levels against vaccine antigens one month after the 4th 36 dose. Overall, antibody responses to the booster dose were lower than the initial peak 37 response to primary immunization and children had higher IgG and IgG1 levels than infants. 38 Higher anti-Rh5 IgG and IgG1-4 levels were detected after the booster dose, suggesting that RTS,S 39 partial protection could increase some blood stage antibody responses. Our work shows that the 40 response to the RTS,S/AS01E booster dose is different from the primary vaccine immune 41 response and highlights the dynamic changes in subclass antibody patterns upon the vaccine 42 booster and with acquisition of adaptive immunity to malaria.2020info:eu-repo/semantics/datasetinfo:eu-repo/semantics/othertext/csvhttps://hdl.handle.net/2445/164777Dades - Recercareponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléscc-by (c) Dobaño et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1647772026-05-27T06:46:51Z
dc.title.none.fl_str_mv	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)
title	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)
spellingShingle	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data) Dobaño, Carlota, 1969- Vacuna de la malària Plasmodium falciparum Moçambic Malaria vaccine Plasmodium falciparum Mozambique
title_short	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)
title_full	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)
title_fullStr	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)
title_full_unstemmed	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)
title_sort	Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)
dc.creator.none.fl_str_mv	Dobaño, Carlota, 1969- Sánchez, Lina Vidal, Marta Jairoce, Chenjerai Tobias Sixpence Aguilar, Ruth Ubillos, Itziar Cuamba, Inocencia Nhabomba, Augusto J. Williams, Nana Aba Diez-Padrisa, Núria Cavanagh, David Angov, Evelina Coppel, Ross L. Gaur, Deepak Beeson, James G. Dutta, Sheetij Aide, Pedro Carlos Paulino Campo, Joseph J. Moncunill Piñas, Gemma
author	Dobaño, Carlota, 1969-
author_facet	Dobaño, Carlota, 1969- Sánchez, Lina Vidal, Marta Jairoce, Chenjerai Tobias Sixpence Aguilar, Ruth Ubillos, Itziar Cuamba, Inocencia Nhabomba, Augusto J. Williams, Nana Aba Diez-Padrisa, Núria Cavanagh, David Angov, Evelina Coppel, Ross L. Gaur, Deepak Beeson, James G. Dutta, Sheetij Aide, Pedro Carlos Paulino Campo, Joseph J. Moncunill Piñas, Gemma
author_role	author
author2	Sánchez, Lina Vidal, Marta Jairoce, Chenjerai Tobias Sixpence Aguilar, Ruth Ubillos, Itziar Cuamba, Inocencia Nhabomba, Augusto J. Williams, Nana Aba Diez-Padrisa, Núria Cavanagh, David Angov, Evelina Coppel, Ross L. Gaur, Deepak Beeson, James G. Dutta, Sheetij Aide, Pedro Carlos Paulino Campo, Joseph J. Moncunill Piñas, Gemma
author2_role	author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Vacuna de la malària Plasmodium falciparum Moçambic Malaria vaccine Plasmodium falciparum Mozambique
topic	Vacuna de la malària Plasmodium falciparum Moçambic Malaria vaccine Plasmodium falciparum Mozambique
description	Study of immune correlates against malaria after vaccination with RTS,S/ASO1E: a comphrensive immunological arm of a Phase III double-blind, randomize, controlled multi-centre trial (MAL067).
publishDate	2020
dc.date.none.fl_str_mv	2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/dataset info:eu-repo/semantics/other
format	dataset
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/164777
url	https://hdl.handle.net/2445/164777
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	cc-by (c) Dobaño et al., 2020 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Dobaño et al., 2020 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	text/csv
dc.source.none.fl_str_mv	Dades - Recerca reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,300719

Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique (Raw Data)

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