Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.

Madrid Gambín, Francisco Javier; Garcia Aloy, Mar; Vázquez Fresno, Rosa; Vegas Lozano, Esteban; Sànchez, Àlex (Sànchez Pla); Misawa, Kohichi; Hase, Tadashi; Shimotoyodome, Akira; Andrés Lacueva, Ma. Cristina

Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.

Functional tea beverages have emerged as a novel approach to achieving health benefits associated with tea. The use of metabolomics may improve the evaluation of their consumption and their effects. The current study aimed to explore the urinary signature of the exposure to a functional high-catechi...

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Autores:	Madrid Gambín, Francisco Javier, Garcia Aloy, Mar, Vázquez Fresno, Rosa, Vegas Lozano, Esteban, Sànchez, Àlex (Sànchez Pla), Misawa, Kohichi, Hase, Tadashi, Shimotoyodome, Akira, Andrés Lacueva, Ma. Cristina
Tipo de recurso:	artículo
Estado:	Versión aceptada para publicación
Fecha de publicación:	2018
País:	España
Institución:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/160397
Acceso en línea:	https://hdl.handle.net/2445/160397
Access Level:	acceso abierto
Palabra clave:	Marcadors bioquímics Te Metabòlits Orina Anàlisi discriminant Espectroscòpia de ressonància magnètica nuclear Biochemical markers Tea Metabolites Urine Discriminant analysis Nuclear magnetic resonance spectroscopy

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spelling	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.Madrid Gambín, Francisco JavierGarcia Aloy, MarVázquez Fresno, RosaVegas Lozano, EstebanSànchez, Àlex (Sànchez Pla)Misawa, KohichiHase, TadashiShimotoyodome, AkiraAndrés Lacueva, Ma. CristinaMarcadors bioquímicsTeMetabòlitsOrinaAnàlisi discriminantEspectroscòpia de ressonància magnètica nuclearBiochemical markersTeaMetabolitesUrineDiscriminant analysisNuclear magnetic resonance spectroscopyFunctional tea beverages have emerged as a novel approach to achieving health benefits associated with tea. The use of metabolomics may improve the evaluation of their consumption and their effects. The current study aimed to explore the urinary signature of the exposure to a functional high-catechin tea (HCT) using untargeted NMR-based metabolomics. Ten volunteers participated in a crossover intervention study. Individuals consumed an HCT or a control beverage over a period of 28 days. Multilevel partial least squares discriminant analysis (ML-PLS-DA) was used for paired comparisons. A further crossover model was performed to assess the significant changes. The consumption of the HCT resulted in the excretion of theanine, epicatechin, pyrogallol sulfate, higher levels of 3-methyl-2-oxovalerate and succinate, as well as unknown compounds. In conclusion, the present work established novel urinary signatures of a functional drink. Such signatures may be potential biomarkers and/or reflect certain benefits of functional tea beverages.American Chemical Society2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/160397Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.8b04198Journal of Agricultural and Food Chemistry, 2018, vol. 67, num. 11, p. 3118-3124https://doi.org/10.1021/acs.jafc.8b04198(c) American Chemical Society , 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1603972026-05-27T06:46:51Z
dc.title.none.fl_str_mv	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.
title	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.
spellingShingle	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine. Madrid Gambín, Francisco Javier Marcadors bioquímics Te Metabòlits Orina Anàlisi discriminant Espectroscòpia de ressonància magnètica nuclear Biochemical markers Tea Metabolites Urine Discriminant analysis Nuclear magnetic resonance spectroscopy
title_short	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.
title_full	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.
title_fullStr	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.
title_full_unstemmed	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.
title_sort	Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.
dc.creator.none.fl_str_mv	Madrid Gambín, Francisco Javier Garcia Aloy, Mar Vázquez Fresno, Rosa Vegas Lozano, Esteban Sànchez, Àlex (Sànchez Pla) Misawa, Kohichi Hase, Tadashi Shimotoyodome, Akira Andrés Lacueva, Ma. Cristina
author	Madrid Gambín, Francisco Javier
author_facet	Madrid Gambín, Francisco Javier Garcia Aloy, Mar Vázquez Fresno, Rosa Vegas Lozano, Esteban Sànchez, Àlex (Sànchez Pla) Misawa, Kohichi Hase, Tadashi Shimotoyodome, Akira Andrés Lacueva, Ma. Cristina
author_role	author
author2	Garcia Aloy, Mar Vázquez Fresno, Rosa Vegas Lozano, Esteban Sànchez, Àlex (Sànchez Pla) Misawa, Kohichi Hase, Tadashi Shimotoyodome, Akira Andrés Lacueva, Ma. Cristina
author2_role	author author author author author author author author
dc.subject.none.fl_str_mv	Marcadors bioquímics Te Metabòlits Orina Anàlisi discriminant Espectroscòpia de ressonància magnètica nuclear Biochemical markers Tea Metabolites Urine Discriminant analysis Nuclear magnetic resonance spectroscopy
topic	Marcadors bioquímics Te Metabòlits Orina Anàlisi discriminant Espectroscòpia de ressonància magnètica nuclear Biochemical markers Tea Metabolites Urine Discriminant analysis Nuclear magnetic resonance spectroscopy
description	Functional tea beverages have emerged as a novel approach to achieving health benefits associated with tea. The use of metabolomics may improve the evaluation of their consumption and their effects. The current study aimed to explore the urinary signature of the exposure to a functional high-catechin tea (HCT) using untargeted NMR-based metabolomics. Ten volunteers participated in a crossover intervention study. Individuals consumed an HCT or a control beverage over a period of 28 days. Multilevel partial least squares discriminant analysis (ML-PLS-DA) was used for paired comparisons. A further crossover model was performed to assess the significant changes. The consumption of the HCT resulted in the excretion of theanine, epicatechin, pyrogallol sulfate, higher levels of 3-methyl-2-oxovalerate and succinate, as well as unknown compounds. In conclusion, the present work established novel urinary signatures of a functional drink. Such signatures may be potential biomarkers and/or reflect certain benefits of functional tea beverages.
publishDate	2018
dc.date.none.fl_str_mv	2018
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion
format	article
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/160397
url	https://hdl.handle.net/2445/160397
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Versió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.8b04198 Journal of Agricultural and Food Chemistry, 2018, vol. 67, num. 11, p. 3118-3124 https://doi.org/10.1021/acs.jafc.8b04198
dc.rights.none.fl_str_mv	(c) American Chemical Society , 2018 info:eu-repo/semantics/openAccess
rights_invalid_str_mv	(c) American Chemical Society , 2018
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Chemical Society
publisher.none.fl_str_mv	American Chemical Society
dc.source.none.fl_str_mv	Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,300719

Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.

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